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re: New drug wipes out 94% of harmful cholesterol with A SINGLE DOSE in trials, lasts a year

Posted on 4/6/25 at 7:17 pm to
Posted by dgnx6
Member since Feb 2006
80265 posts
Posted on 4/6/25 at 7:17 pm to
quote:

And for this reason, the Covidtards are out.



Still waiting on the winter of death.




But this would be a big deal.


Posted by dgnx6
Member since Feb 2006
80265 posts
Posted on 4/6/25 at 7:23 pm to
quote:

Old ‘drug’ wipes out harmful cholesterol too. Eat well Regular exercise Hydrate Sunlight Sleep well You are little pharma. Own it!



While this can help you can also just inherit high cholesterol.

My grandfather died young of a heart attack. Dude was hard as steel and still ran and exercised regularly.













Posted by LSUSUPERSTAR
TX
Member since Jan 2005
16692 posts
Posted on 4/6/25 at 8:52 pm to
quote:

Can you read?


You obviously have very linear thinking. If that is something you can't change, eating better foods will reduce other risk factors. Meaning that qonr ststic risk factor alone won't kill you unless you compound it with a poor diet causing inflammation. My patience with people grows less as I get older.
Posted by Earnest_P
Member since Aug 2021
4550 posts
Posted on 4/6/25 at 9:42 pm to
There’s no such thing as bad cholesterol.
Posted by buffbraz
Member since Nov 2005
5722 posts
Posted on 4/6/25 at 10:07 pm to
quote:

and it entered phase 2 of drug trials on March 31
quote:

announced positive Phase 2 results for lepodisiran,
quote:

The ACCLAIM-Lp(a) Phase 3 clinical development program, investigating the effect of lepodisiran on the reduction of cardiovascular events in adults with elevated Lp(a), is currently enrolling.
Press Release

Phase 2 results have been disclosed. It’s beginning enrollment for phase 3.
Posted by SundayFunday
Member since Sep 2011
9647 posts
Posted on 4/6/25 at 10:13 pm to
quote:

Imagine when their's a breakthrough that prevents the build up of plaque deposits in the brain that Alzheimer's patients suffer from. Will big pharma pull the plug on AI since they make so much revenue treating patients?


There are a handful that have been shown to remove nearly all (if not all) detectable amyloid plaques on imaging of patients with alzheimer disease. It doesnt improve their cognition however and only seems to slow things if the disease was caught early enough - having said that, we aren't sure why thats the case yet. A few other things come into play but taking those into account, the exact mechanism of cerebral deterioration in AD is not understood enough.
Posted by buffbraz
Member since Nov 2005
5722 posts
Posted on 4/6/25 at 10:18 pm to
quote:

Modern pharma and our modern medical system hasn’t cured anything, ever. Like every other business model, they are trying to turn us into subscription buyers.


LINK
quote:

“Story of Discovery: Hepatitis C: from non-A, non-B hepatitis to a cure


I would also argue that antibiotics and excising and treating cancers could be considered cures as well (possibly organ transplantation)

Forgot to add, my wife had Hodgkin’s lymphoma in 2009. She received the proper “modern Pharma” treatment and is alive today and healthy as a horse. Without modern medicine and Pharma, she wouldn’t be alive. She was cured of cancer.
This post was edited on 4/6/25 at 10:27 pm
Posted by ole man
Baton Rouge
Member since Nov 2007
15075 posts
Posted on 4/7/25 at 5:48 am to
They already know what the side effects are, they just donna lie and say it 97% effective,

.A Single dose yeh i believe that shite.
Posted by Roaad
White Privilege Broker
Member since Aug 2006
79612 posts
Posted on 4/7/25 at 5:49 am to
Copy that, I'll fix the OP
Posted by Roaad
White Privilege Broker
Member since Aug 2006
79612 posts
Posted on 4/7/25 at 5:52 am to
quote:

They already know what the side effects are
Not really

It is hard to have a real picture of long-term side effects until there are people on the drug for years.
Posted by N2cars
Member since Feb 2008
34917 posts
Posted on 4/7/25 at 6:01 am to
Incorrect.

Testing techniques and carefully-monitored trials reveal side effects before the drugs are available for general consumption.
All the results are readily available.

ETA; you said long-term, I agree, but they usually aren't significant

This post was edited on 4/7/25 at 6:04 am
Posted by PureBlood
The Motherland
Member since Oct 2021
4910 posts
Posted on 4/7/25 at 6:16 am to
quote:

Wonder what the side effects down the road will be?



Dying suddenly
Posted by Roaad
White Privilege Broker
Member since Aug 2006
79612 posts
Posted on 4/7/25 at 6:18 am to
quote:

Dying suddenly
could be

Or maybe gas
Posted by Roaad
White Privilege Broker
Member since Aug 2006
79612 posts
Posted on 4/7/25 at 6:19 am to
quote:

but they usually aren't significant
Aren't we finding out now about severe intestinal blockage and hair loss from Semiglutides?
Posted by N2cars
Member since Feb 2008
34917 posts
Posted on 4/7/25 at 6:44 am to
Ive heard that, but any studies to back it up up? % of people affected?

And do the pros outweigh (haha) the cons?
Posted by Roaad
White Privilege Broker
Member since Aug 2006
79612 posts
Posted on 4/7/25 at 7:04 am to
I am not arguing they are widespread, only significance of the side effect.

The studies are being done now, as i recall.
Posted by N2cars
Member since Feb 2008
34917 posts
Posted on 4/7/25 at 7:26 am to




Posted by buffbraz
Member since Nov 2005
5722 posts
Posted on 4/7/25 at 7:31 am to
Typically serious side effects are elucidated in longer term phase three trials with a higher number of participants. But there’s no way to know what the effects of extremely long term drug use are unless you completed a a 10 or 20 year phase 3 trial before seeking FDA approval. That doesn’t make a lot of sense. If serious side effects are seen AFTER approval and they are serious enough, they will pull the drug off the market, see Raptiva.
Posted by buffbraz
Member since Nov 2005
5722 posts
Posted on 4/7/25 at 7:35 am to
quote:

Aren't we finding out now about severe intestinal blockage and hair loss from Semiglutides?


These are in the full prescribing information and were shown in the phase three pivotal trials.



Posted by Roaad
White Privilege Broker
Member since Aug 2006
79612 posts
Posted on 4/7/25 at 7:52 am to
quote:

That doesn’t make a lot of sense
I am not arguing it should happen.

I am saying these miracle drugs tend to have hammers that drop, of varying severity, down the road.

This line of contentious discussion just arose from me saying I wonder what the long term side effects will be, in good faith.

Hell, it could just be gas. . .or your balls could fall off. Nobody knows yet, but it will be something.
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