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re: Is fibromyalgia real?
Posted on 4/20/21 at 7:56 pm to crazy4lsu
Posted on 4/20/21 at 7:56 pm to crazy4lsu
quote:
to increased Substance P and glutamate in the SC, decreased blood flow in the thalamus, HPA axis hypofunction, low serotonin levels, and possible cytokine abnormalities (with respect only to increased serum levels of IL-1 and IL-8, if I remember).
Is this the cause of FM or the effects of FM? Do they have low serotonin levels due to FM, or does the severe depression due to low serotonin levels cause physical pain? Is the increase in substance P in the CSF a cause, or is just the effect? Would an intrathecal tabasco pump help deplete the substance P and give them relief?
1
Posted on 4/20/21 at 7:56 pm to TigerDat
quote:
It’s a lazy woman’s disease
Nope I've seen a few soy boys claiming the diagnosis
Posted on 4/20/21 at 7:58 pm to GreenRockTiger
quote:
The women I have known who have this were either very depressed or very overweight - once either of those things were properly treated - the fibromyalgia went away as well. I’m not saying it’s necessarily totally fake, but maybe more of a symptom to another problem.
No I’m not a doctor and yes I know that’s anecdotal.
i mean... anecdotal experiences are legitimate to an extent and can reveal truths about a patients behavioral patterns. however, anecdotes are also influenced by personal perspective.
... and, i will be one quite soon just not the kind anyone cares about.
Posted on 4/20/21 at 8:00 pm to thadcastle
I used to think it was BS....but have since changed my mind
Posted on 4/20/21 at 8:01 pm to LSUgirl4
quote:
i will be one quite soon just not the kind anyone cares about.
Awww that can’t be true
This post was edited on 4/20/21 at 8:21 pm
Posted on 4/20/21 at 8:04 pm to Ric Flair
quote:
Is this the cause of FM or the effects of FM?
Given the altered allele frequencies among candidate genes, including some mu opioid receptor genes, I would wager these are effects and not causes. Given that knowledge, my inclination is to regard FM as a group of disorders that include dysregulation of pain processing with cognitive and musculoskeletal sequelae, with some inflammatory markers present, and some HPA axis and NT dysfunction. I don't think a specific, distinct pathophysiology has been worked out yet, but the genetic data is promising. Given my education was strictly on the molecular aspects of this disorder, I couldn't suggest any new treatment course.
This post was edited on 4/20/21 at 8:05 pm
Posted on 4/20/21 at 8:06 pm to DaBeerz
Very accurate answer unfortunately
Posted on 4/20/21 at 8:13 pm to crazy4lsu
Any studies on CRPS (ie RSD/causalgia) in regards to serotonin/CSF substance P/etc?
Posted on 4/20/21 at 8:15 pm to Ric Flair
I believe there are actually. Do you want the DOI numbers?
Posted on 4/20/21 at 8:16 pm to thadcastle
It’s something every white lady has and they’re all fat/out of shape
Posted on 4/20/21 at 8:19 pm to crazy4lsu
Was just wondering if findings were similar. I’m thinking immobility—>spasms—>pain—>further immobility—>cycle repeats itself.
ETA:
CRPS obviously has an autonomic component that is abberantly unregulated. But it is also treated with steroids, unlike FM.
ETA:
CRPS obviously has an autonomic component that is abberantly unregulated. But it is also treated with steroids, unlike FM.
This post was edited on 4/20/21 at 8:25 pm
Posted on 4/20/21 at 8:22 pm to Old Money
quote:
It’s something every white lady has if they’re all fat/out of shape
FIFY
I don’t have it
Posted on 4/20/21 at 8:22 pm to thadcastle
It’s as real as its cousin chronic fatigue syndrome
This post was edited on 4/20/21 at 8:23 pm
Posted on 4/20/21 at 8:27 pm to GreenRockTiger
quote:
FIFY
I don’t have it
Okay, fair point on the fix.
Posted on 4/20/21 at 8:30 pm to Old Money
quote:
Okay, fair point on the fix.
Posted on 4/20/21 at 8:39 pm to thadcastle
It is real but the hypochondriacs ruin it for the people who keep fighting thru the pain.
Posted on 4/20/21 at 8:41 pm to thadcastle
quote:Until you’ve given birth, have a menstrual cycle, and estrogen as your primary hormone, your opinion on all things regarding women’s health isn’t necessary or wanted.
just a reason for women to complain
Posted on 4/20/21 at 8:44 pm to thadcastle
George floyd had it I think
Posted on 4/20/21 at 8:50 pm to tigergirl10
most woman-sounding thing you’ve posted to date.
Posted on 4/20/21 at 8:53 pm to Ric Flair
I think a likely process is nonpainful stimuli regarded as painful, with an inflammatory response followed by/coincides with dysregulation of cellular muscle function, which magnifies the inflammatory response. But I have to more in the literature.
This post was edited on 4/20/21 at 9:14 pm
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