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Message
re: Fauci has basically been committing scaphism (the boats) on innocent beagles
Posted on 10/24/21 at 4:25 pm to UndercoverBryologist
Posted on 10/24/21 at 4:25 pm to UndercoverBryologist
quote:
LSUJML I don’t know. It seems, based on the info in your comment, that the FDA/CDC puts a pretty high barrier to prescribing DEC for humans. I wonder if, perhaps, the CDC doesn’t permit its use at all for veterinary medicine
LINK
I’ll answer my own question.
quote:
Historically, DEC was widely used for heartworm prevention in dogs. It was given daily PO throughout the mosquito season to prevent patent infections. Before DEC use, dogs must first be cleared of adult heartworms and microfilariae to avoid an often fatal reaction. DEC has also been used to treat prepatent Dictyocaulus viviparus infections (see Lungworm Infection) in cattle, although it is relatively ineffective against the adult worms. It is routinely given IM at 22 mg/kg body wt for 3 consecutive days, although it is reported that one injection at 44 mg/kg provides better relief of clinical signs.
1
Posted on 10/24/21 at 4:29 pm to UndercoverBryologist
My point was the UGA guy was saying it was for a disease that affected 120 million people & had no cure
The other guy in the article named the disease
When I looked it up I saw the CDC site listing the treatment but that it was not FDA cleared because it was so rare
The other guy in the article named the disease
When I looked it up I saw the CDC site listing the treatment but that it was not FDA cleared because it was so rare
Posted on 10/24/21 at 4:36 pm to LSUJML
quote:
My point was the UGA guy was saying it was for a disease that affected 120 million people & had no cure
I’m not going to speak for the UGA spokesperson other than to say trying to get all the scientific information accurately into a single pithy public statement is trickier than it might seem.
It seems that the “no known cure” part was strictly related to the disease in dogs themselves. (It was referencing the need for euthanasia.) It does seem that once the pathophysiology of the disease has progressed to a certain point, it may be difficult and damn near impossible to save the dogs. First you have to physically remove the worms. Then start DEC and hope it is still effective.
Posted on 10/24/21 at 4:39 pm to UndercoverBryologist
This could be your answer:
In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016
Pharmacokinetics
Diethylcarbamazine is extensively metabolized, the half-life being 6–12 hours; the remainder enters the urine within 48 hours. Over the initial period the dosage should be increased slowly to avoid or reduce allergic responses as a result of destruction of parasites and liberation of antigen, and then maintained at 3 mg/kg tds for 34 weeks. Not all of its adverse effects are necessarily due to destruction of the parasite; weakness, lethargy, anorexia, and nausea can be due to the drug itself.
Thomas B. Nutman, in The Travel and Tropical Medicine Manual (Fifth Edition), 2017
Treatment
DEC is the drug of choice for treatment of TPE, the dose typically being 6?mg/kg per day for 14 days. Symptoms usually resolve between days 4 and 7 of therapy. Characteristically, respiratory symptoms rapidly resolve after treatment with DEC. Despite dramatic initial improvement after conventional treatment with DEC, symptoms recur in approximately 20% of patients 12-24 months after treatment, and a majority of patients continue to have subtle clinical, radiographic, and functional abnormalities. Repeat treatment may be necessary to prevent pulmonary fibrosis, a serious sequela of TPE if left untreated.
Approaches to Design and Synthesis of Antiparasitic Drugs
Satyavan Sharma, Nitya Anand, in Pharmacochemistry Library, 1997
4.1.2 Diethylcarbamazine (DEC, 3)
Diethylcarbamazine has been found to be active against adult ascarids in cats and dogs. However a combination of DEC (3 mg/kg) and styrylpyridinium chloride (5 mg/kg) gave protection against hookworms, ascarids and heartworms in dogs. DEC has also been used as a prophylactic agent against canine heartworm disease at a dose of 5.5 mg/kg given daily during the mosquito season plus an additional two months [56].
DEC has no action on the microfilaria or adult worms of L. carinii in vitro, but exhibits lethal action on the filariids in vivo. The drug kills > 90% of the microfilariae circulating in the blood in cotton rats, Mongolian jirds and Mastomys natalensis infected with L. carinii at an intraperitoneal dose of 6 mg/kg given for 5 days [59,60]. However, DEC has little or no action against the microfilariae of Dipetalonema perstans, Dipetalonema viteae and Dirofilaria repens in jirds and dogs [7,16]. The drug has been found to be highly effective against microfilariae of Onchocerca cervicalis, O. gutturosa and O. gibsoni in horses and cattle at a dose of 20 mg/kg given for 3-5 days [62]. The pre-adult developing stages of D.immitis in dogs may be killed at a dose of 55 mg/kg of DEC [61].
The action of DEC on adult filarial worms is species dependent. The drug shows only poor or no activity on the macrofilariae of L.carinii and D. viteae. in rodents and Dirofilaria immitis and D.repens in dogs. The adult worms of O. volvulus are also not susceptible to DEC. However, DEC has been found to kill the adult worms of Brugia pahangi, B.malayi, W.bancrofti, L. loa, Dipetalonema streptocerca and Setaria digitata in different animals [7,62].
Tissue Nematodes (Trichinellosis, Dracunculiasis, Filariasis, Loiasis, and Onchocerciasis)
James W. Kazura, in Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases (Eighth Edition), 2015
Therapy
Diethylcarbamazine at a dose of 8 to 10?mg/kg/day for 21 days should be given to persons who do not have microfilaremia. Repeated treatment courses with diethylcarbamazine may be necessary in 40% to 50% of patients. Calabar swelling, pruritus, and eye worms may be precipitated by treatment. Side effects can be minimized by concurrent administration of antihistamines or corticosteroids. In persons with high-level microfilaremia (>2500/mL), there is a significant risk for renal and central nervous system complications due to the rapid destruction of large numbers of microfilariae. Options include withholding anthelmintic drugs, cytapheresis to remove microfilariae before administration of diethylcarbamazine, and administration of a single dose of ivermectin.
Neglected Diseases: Extensive Space for Modern Drug Discovery
Stefano Sainas, ... Marco L. Lolli, in Annual Reports in Medicinal Chemistry, 2018
4.4 Diethylcarbamazine Patch Test
Diethylcarbamazine was the drug of choice for onchocerciasis therapy for 30 years. However, treatment with diethylcarbamazine provokes side effects in patients infected with O. volvulus that have been named the Mazzotti reaction. These reactions, which occur within a few hours after an oral dose, include, dermal edema, lymphadenopathy, itching, fever, maculopapular eruptions, but also more severe manifestations such as meningism, arthropathy, tachycardia, hypotension, severe prostration, and even death.94 The mechanism of action is thought one of the inflammatory reactions, particularly involving eosinophils, associated with the exposure and killing of the microfilariae.
In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016
Pharmacokinetics
Diethylcarbamazine is extensively metabolized, the half-life being 6–12 hours; the remainder enters the urine within 48 hours. Over the initial period the dosage should be increased slowly to avoid or reduce allergic responses as a result of destruction of parasites and liberation of antigen, and then maintained at 3 mg/kg tds for 34 weeks. Not all of its adverse effects are necessarily due to destruction of the parasite; weakness, lethargy, anorexia, and nausea can be due to the drug itself.
Thomas B. Nutman, in The Travel and Tropical Medicine Manual (Fifth Edition), 2017
Treatment
DEC is the drug of choice for treatment of TPE, the dose typically being 6?mg/kg per day for 14 days. Symptoms usually resolve between days 4 and 7 of therapy. Characteristically, respiratory symptoms rapidly resolve after treatment with DEC. Despite dramatic initial improvement after conventional treatment with DEC, symptoms recur in approximately 20% of patients 12-24 months after treatment, and a majority of patients continue to have subtle clinical, radiographic, and functional abnormalities. Repeat treatment may be necessary to prevent pulmonary fibrosis, a serious sequela of TPE if left untreated.
Approaches to Design and Synthesis of Antiparasitic Drugs
Satyavan Sharma, Nitya Anand, in Pharmacochemistry Library, 1997
4.1.2 Diethylcarbamazine (DEC, 3)
Diethylcarbamazine has been found to be active against adult ascarids in cats and dogs. However a combination of DEC (3 mg/kg) and styrylpyridinium chloride (5 mg/kg) gave protection against hookworms, ascarids and heartworms in dogs. DEC has also been used as a prophylactic agent against canine heartworm disease at a dose of 5.5 mg/kg given daily during the mosquito season plus an additional two months [56].
DEC has no action on the microfilaria or adult worms of L. carinii in vitro, but exhibits lethal action on the filariids in vivo. The drug kills > 90% of the microfilariae circulating in the blood in cotton rats, Mongolian jirds and Mastomys natalensis infected with L. carinii at an intraperitoneal dose of 6 mg/kg given for 5 days [59,60]. However, DEC has little or no action against the microfilariae of Dipetalonema perstans, Dipetalonema viteae and Dirofilaria repens in jirds and dogs [7,16]. The drug has been found to be highly effective against microfilariae of Onchocerca cervicalis, O. gutturosa and O. gibsoni in horses and cattle at a dose of 20 mg/kg given for 3-5 days [62]. The pre-adult developing stages of D.immitis in dogs may be killed at a dose of 55 mg/kg of DEC [61].
The action of DEC on adult filarial worms is species dependent. The drug shows only poor or no activity on the macrofilariae of L.carinii and D. viteae. in rodents and Dirofilaria immitis and D.repens in dogs. The adult worms of O. volvulus are also not susceptible to DEC. However, DEC has been found to kill the adult worms of Brugia pahangi, B.malayi, W.bancrofti, L. loa, Dipetalonema streptocerca and Setaria digitata in different animals [7,62].
Tissue Nematodes (Trichinellosis, Dracunculiasis, Filariasis, Loiasis, and Onchocerciasis)
James W. Kazura, in Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases (Eighth Edition), 2015
Therapy
Diethylcarbamazine at a dose of 8 to 10?mg/kg/day for 21 days should be given to persons who do not have microfilaremia. Repeated treatment courses with diethylcarbamazine may be necessary in 40% to 50% of patients. Calabar swelling, pruritus, and eye worms may be precipitated by treatment. Side effects can be minimized by concurrent administration of antihistamines or corticosteroids. In persons with high-level microfilaremia (>2500/mL), there is a significant risk for renal and central nervous system complications due to the rapid destruction of large numbers of microfilariae. Options include withholding anthelmintic drugs, cytapheresis to remove microfilariae before administration of diethylcarbamazine, and administration of a single dose of ivermectin.
Neglected Diseases: Extensive Space for Modern Drug Discovery
Stefano Sainas, ... Marco L. Lolli, in Annual Reports in Medicinal Chemistry, 2018
4.4 Diethylcarbamazine Patch Test
Diethylcarbamazine was the drug of choice for onchocerciasis therapy for 30 years. However, treatment with diethylcarbamazine provokes side effects in patients infected with O. volvulus that have been named the Mazzotti reaction. These reactions, which occur within a few hours after an oral dose, include, dermal edema, lymphadenopathy, itching, fever, maculopapular eruptions, but also more severe manifestations such as meningism, arthropathy, tachycardia, hypotension, severe prostration, and even death.94 The mechanism of action is thought one of the inflammatory reactions, particularly involving eosinophils, associated with the exposure and killing of the microfilariae.
Posted on 10/24/21 at 4:43 pm to UndercoverBryologist
quote:
Submitted without comment to the veracity of the spokesperson’s statement, here is an official statement from the University of Georgia, which headed the American part of the study:
They are admitting to torturing dogs. Their Mascot is a dog.
Posted on 10/24/21 at 4:43 pm to Kjnstkmn
quote:
I raise beagles and hunt rabbits with them
“How DARE someone kill the animals that I use to kill other animals!!!!1!!!11111!!”
Is this the new thing that Q told you lunatics to be outraged about?
Posted on 10/24/21 at 4:48 pm to St Stooge
ooof, what a weird melt regardless of the validity of the OP.
Posted on 10/24/21 at 4:48 pm to St Stooge
quote:
How DARE someone kill the animals that I use to kill other animals!!!!1!!!11111!!”
Is this the new thing that Q told you lunatics to be outraged about?
^this is what indoctrination looks like in case anyone is wondering. He’s willing to defend torturing puppies rather than go against accepted party propaganda. Wish I could say I’m surprised. But I’m not.
Posted on 10/24/21 at 4:52 pm to Ghost of Colby
Is there any doubt left that Fauci would have funded Dr. Mengele at this point?
Posted on 10/24/21 at 4:52 pm to Darth_Vader
quote:
torturing puppies
The ethical justification for this is that this is a disease already present in the dog population, so this research would benefit more dogs than those sacrificed in the trial.
Same thing happens in Ebola research. Monkeys get Ebola same as humans, so vets justify giving Ebola to monkeys in the rationale than any vaccine developed would benefit the monkey population as a whole.
Edit: Believe me, it’s an ethical dilemma that keeps researchers up at night pondering. It’s one of the reasons I went into botany.
This post was edited on 10/24/21 at 4:54 pm
Posted on 10/24/21 at 4:53 pm to SoFla Tideroller
quote:
Is there any doubt left that Fauci would have funded Dr. Mengele at this point?
When I read this story Mengele is actually the first thing I thought of. Fauci and he were cut from the same cloth.
Posted on 10/24/21 at 4:53 pm to Eighteen
"I’d argue he actual made things worse because instead of being a leader, he constantly jumped in front of a camera and give vague wish washy answers and constantly contradicted himself. He scared people, confused people, and helped push policies that were overreaching and harmful to the youth of our nation"
I don't really think about Fauci one way or the another.
Honestly, when you are dealing with a novel disease, guess what, even people with a lot of expertise are doing educated guesswork and there are NO non- wishy washy, vague answers because no one truly knows the exact answers yet. And good leadership should admit that because those maligned broad-range "overabundance of caution" edicts are the correct path until more solid answers are known.
And nothing has harmed the youth of our nation more than modern technology, which has also helped them. Before that it was something else. Like it has always has been and always will be. Humanity's ways of thinking are constantly evolving, and they will continue to do so. Action and reaction, fear and curiosity constantly tugging on the human mind.
I don't really think about Fauci one way or the another.
Honestly, when you are dealing with a novel disease, guess what, even people with a lot of expertise are doing educated guesswork and there are NO non- wishy washy, vague answers because no one truly knows the exact answers yet. And good leadership should admit that because those maligned broad-range "overabundance of caution" edicts are the correct path until more solid answers are known.
And nothing has harmed the youth of our nation more than modern technology, which has also helped them. Before that it was something else. Like it has always has been and always will be. Humanity's ways of thinking are constantly evolving, and they will continue to do so. Action and reaction, fear and curiosity constantly tugging on the human mind.
Posted on 10/24/21 at 4:57 pm to UndercoverBryologist
quote:
The ethical justification for this is that this is a disease already present in the dog population, so this research would benefit more dogs than those sacrificed in the trial.
Same thing happens in Ebola research. Monkeys get Ebola same as humans, so vets justify giving Ebola to monkeys in the rationale than any vaccine developed would benefit the monkey population as a whole.
Edit: Believe me, it’s an ethical dilemma that keeps researchers up at night pondering. It’s one of the reasons I went into botany.
So is there no other way to infect the dogs besides putting their head in box and letting flies eat them alive?
Posted on 10/24/21 at 5:00 pm to Darth_Vader
quote:
So is there no other way to infect the dogs besides putting their head in box and letting flies eat them alive?
Would you find it more appealing to your sensibilities if the dog was allowed to roam in a cage but the flies were still allowed to infect them with a deadly parasite?
Posted on 10/24/21 at 5:06 pm to UndercoverBryologist
quote:
Would you find it more appealing to your sensibilities if the dog was allowed to roam in a cage but the flies were still allowed to infect them with a deadly parasite?
So you’re telling me there’s no humane manner to infect these dogs? But even this is better than what they’ve been doing. I understand animal research is needed and beneficial. But it’s not necessary to torture them. If you think there is then you’re no better than Fauci or Megele for that matter.
Posted on 10/24/21 at 5:10 pm to Darth_Vader
Perhaps there are cracks though which unnecessary and torturous animal research gets approved. But when I was messing around and about in animal labs in undergrad, I remember the regulations on animal research being arduous. You had to prove beyond a shadow of a doubt that the research could not be done any other way, that the animals would be cared for to the best of the ability allowed for under the experimental design, and that the research could potentially benefit more animals than would be sacrificed in the lab.
It was long training...another reason I went into botany.
It was long training...another reason I went into botany.
Posted on 10/24/21 at 5:13 pm to St Stooge
Rabbits are food libtard, like cows and pigs. Also, we don’t torture them by feeding them to sandflies for 22 months, quick humane kill and into the jambalaya they go.
Rabbits are also commonly used lab test animals, although I would hope they are seldom submitted to this kind of cruel torture.
The outrage is using beagle puppies for this.
Dogs are mans best friend. This is not Korea or China.
Your comparison is ridiculous as are you. Maybe you should hang out on Reddit with your own kind.
Rabbits are also commonly used lab test animals, although I would hope they are seldom submitted to this kind of cruel torture.
The outrage is using beagle puppies for this.
Dogs are mans best friend. This is not Korea or China.
Your comparison is ridiculous as are you. Maybe you should hang out on Reddit with your own kind.
This post was edited on 10/24/21 at 5:18 pm
Posted on 10/24/21 at 5:14 pm to UndercoverBryologist
quote:
Same thing happens in Ebola research. Monkeys get Ebola same as humans, so vets justify giving Ebola to monkeys in the rationale than any vaccine developed would benefit the monkey population as a whole.
Speaking of Ebola in monkeys. Have you ever watched "Outbreak" or read "The Hot Zone"? Those are both based on a real incident where Ebola was on the loose in Reston, Virginia. Yes, THAT Ebola. A government research lab ordered some monkeys to do other research on and they started dying until they were dead. The researchers couldn't figure out why they were dying until they were dead until they looked at their blood and tissue samples under an electron microscope and HOLY frick, THAT'S EBOLA!
Luckily, their "super safe nothing can get out" lab was until it wasn't. They figured this out when they tested everyone at the lab and several caretakers popped up seropositive for Ebola. Apparently, this strain will murder the frick out of monkeys and is so infectious that it jumped from monkey to monkey and across lab barriers as if they weren't even there. It infects humans, too, but causes no symptoms in humans. It, however, is 100% Ebola.
Look up Ebola Reston sometime. Also, look up how close Reston is to D.C.
This post was edited on 10/24/21 at 5:16 pm
Posted on 10/24/21 at 5:14 pm to OMLandshark
Well, it is no coincidence it was done in Tunisia which is predominately Muslim.
Since Muslims consider dogs as dirty; I bet they enjoyed the hell out of torturing puppies.
What religion is Fauxi? Anyone know?
He is evil; we know that much.
Since Muslims consider dogs as dirty; I bet they enjoyed the hell out of torturing puppies.
What religion is Fauxi? Anyone know?
He is evil; we know that much.
Posted on 10/24/21 at 5:15 pm to Darth_Vader
quote:
So you’re telling me there’s no humane manner to infect these dogs? But even this is better than what they’ve been doing. I understand animal research is needed and beneficial. But it’s not necessary to torture them. If you think there is then you’re no better than Fauci or Megele for that matter.
There is a reason they are heavily sedated in those pictures...
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