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re: Dianna Cowern, Physics Girl...one of my YT follows...is fighting Long COVID.
Posted on 2/15/23 at 12:07 pm to GumboPot
Posted on 2/15/23 at 12:07 pm to GumboPot
People that feel the need to give a play by play of their ‘sickness’ on social media fricking suck
Our society has got to stop enabling these narcissistic, self loving losers
Our society has got to stop enabling these narcissistic, self loving losers
0
Posted on 2/15/23 at 12:11 pm to GumboPot
Need more pics to see if I give a shite.
Posted on 2/15/23 at 12:11 pm to GumboPot
Our family got hit by COVID twice last year and the flu. The flu was worse overall, we were dumb and didn't get tested early enough to get tamiflu.
Each time took us down for days with fever and fatigue, followed by chronic cough and malaise. But each time there was also a point where we had to make up our minds to get our asses up and push through life without concern of getting better first. And wouldn't you know it, that seemed to trigger getting over the hump each time.
She sounds like she just doesn't want to push through.
Each time took us down for days with fever and fatigue, followed by chronic cough and malaise. But each time there was also a point where we had to make up our minds to get our asses up and push through life without concern of getting better first. And wouldn't you know it, that seemed to trigger getting over the hump each time.
She sounds like she just doesn't want to push through.
Posted on 2/15/23 at 12:13 pm to GumboPot
How long before this is an easy way to claim disability and get a check for doing nothing?
Posted on 2/15/23 at 12:32 pm to ChuckM
quote:
Need more pics to see if I give a shite.
Posted on 2/15/23 at 12:38 pm to GumboPot
Flu vax Dystonia girl and her would get along great
Posted on 2/15/23 at 12:40 pm to BeachDude022
Long COVID is as real as fibromyalgia
Posted on 2/15/23 at 12:54 pm to HodsonTiger13
quote:I have a friend w/ migraine headaches -- started / COVID. Still having them 11 months later.
"Long Covid" is a thing. Know someone with a 6-month cough from it. Another person in a 'mental fog' for about the same amount of time.
Posted on 2/15/23 at 1:00 pm to GumboPot
quote:
What clinical test were used to confirm long covid? Just curious.
It depends on the patient. Sometimes we see elevated inflammatory markers, immune cell dysfunction, sometimes anemia, low cortisol levels, etc. I know no one is going to listen to me, but there is a growing body of data that COVID is also a disorder of immune modulation. One thing people seem to forget is that the initial thrust to use HCQ was based on its anti-inflammatory properties, as it is used in rheumatological disorders as well. In addition, Ivermectin also has anti-inflammatory properties as well, which should suggest something about the nature of the disease in question.
So far, there have been associations between COVID and pulmonary fibrosis, heart disease, HPA axis dysfunction and T-cell exhaustion, among other associations. That there is evidence of HLA mediation can explain the wide variety of presentations you see in COVID infections, where I've long remarked about the wide differences in the quality of infections between two related individuals.
Posted on 2/15/23 at 1:41 pm to crazy4lsu
quote:
One thing people seem to forget is that the initial thrust to use HCQ was based on its anti-inflammatory properties
I thought is was due to HCQ raising intracellular pH and allowing that pH gradient to promote zinc ion transport across the cell membrane and once the zinc ion is in the cytoplasm it interrupts RNA polymerase, thus slowing down viral replication?
quote:
Ivermectin also has anti-inflammatory properties as well, which should suggest something about the nature of the disease in question.
I don't doubt ivermectin's anti-inflammatory properties but I though ivermectin's anti-virial properties are due to it's affinity of binding with ACE2, and the COVID virus needs ACE2 to get past the cell membrane?
Posted on 2/15/23 at 4:19 pm to MugMan
quote:
So was Robin Williams.
To be fair, he was suffering from a miserable illness in addition to depression. Wanted to end it.
Posted on 2/15/23 at 4:25 pm to GumboPot
quote:
I thought is was due to HCQ raising intracellular pH and allowing that pH gradient to promote zinc ion transport across the cell membrane and once the zinc ion is in the cytoplasm it interrupts RNA polymerase, thus slowing down viral replication?
That was the oft-repeated mechanism, but clinically it didn’t show those specific anti-viral properties from what I recall. The textbook immunopharmocologic mechanism (also proposed) is that it suppresses antigen processing by increasing the pH of lysosomal and endosomal compartments which eventually leads to decreased T-Cell activation. The zinc motif proposal has also been suggested for doxycycline.
quote:
I don't doubt ivermectin's anti-inflammatory properties but I though ivermectin's anti-virial properties are due to it's affinity of binding with ACE2, and the COVID virus needs ACE2 to get past the cell membrane?
Again, that was the proposed mechanism. Anecdotally I’ve heard of positive effects of Ivermectin with respect to long COVID, which suggests that positive effects might be along immunomodulatory grounds rather than viral entry inhibition.
Posted on 2/15/23 at 4:49 pm to bayouvette
quote:
Well it is a respitory virus just like the flu..
And the flu magically disappeared for a couple years.
Posted on 2/15/23 at 4:53 pm to BeachDude022
quote:
Covid isn’t real, remember? The OT said so. It’s just the flu
The flu can be pretty bad mate.
I don’t know why people act like the flu isn’t bad when it kills people every year.
Just supposedly not when covid is around. Wink wink
Posted on 2/15/23 at 5:45 pm to ShoeBang
Stay strong and know there is help out there if you need it.
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