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re: Coronavirus Disease 2019 (COVID-19) ***W.H.O. DECLARES A GLOBAL PANDEMIC***

Posted on 3/17/20 at 2:29 pm to
Posted by rds dc
Member since Jun 2008
21549 posts
Posted on 3/17/20 at 2:29 pm to
quote:

At a time when everyone needs better information, from disease modelers and governments to people quarantined or just social distancing, we lack reliable evidence on how many people have been infected with SARS-CoV-2 or who continue to become infected. Better information is needed to guide decisions and actions of monumental significance and to monitor their impact.


quote:

That huge range markedly affects how severe the pandemic is and what should be done. A population-wide case fatality rate of 0.05% is lower than seasonal influenza. If that is the true rate, locking down the world with potentially tremendous social and financial consequences may be totally irrational. It’s like an elephant being attacked by a house cat. Frustrated and trying to avoid the cat, the elephant accidentally jumps off a cliff and dies.


LINK

Counter point from Stat News. He is getting considerably blowback from peers, esp for not discussing the SK data that contains testing of nearly 1 in every 200 citizens and a nCFR of 1%.


This post was edited on 3/17/20 at 2:31 pm
Posted by TDsngumbo
Member since Oct 2011
50809 posts
Posted on 3/17/20 at 2:31 pm to
quote:

@Reuters
Italy will rush 10,000 student doctors into service, scrapping their final exams, in an effort to help the struggling health service cope with the #coronavirus outbreak LINK (1/4)

Damn, imagine a scenario where it’s such a dire situation that the government tells students, “you know what, you’re probably good enough. Come on over and save these peoples’ lives”.

Posted by JonTigerFan11
Member since May 2016
892 posts
Posted on 3/17/20 at 2:31 pm to
Can further confirm that Touro is not even using their ICU to house the corona patients, as that would be "ignorant to have contagious people around the most severely sick".

They are using a completely separate ward of the hospital.
Posted by WaWaWeeWa
Member since Oct 2015
15714 posts
Posted on 3/17/20 at 2:34 pm to
quote:

Pretty sure Remdesivir is Tamiflu or very similar


Remdesivir was an antiviral created for Ebola. It wasn’t very effective for Ebola. It showed promise in the first case of COVID in Washington but the patient was a healthy 30 year old. They have alot to prove with further testing. The good news is we know it’s safe.

I’m more excited about chloroquine. It’s an old drug. Cheap and prevalent.
This post was edited on 3/17/20 at 2:35 pm
Posted by NYNolaguy1
Member since May 2011
21764 posts
Posted on 3/17/20 at 2:35 pm to
NYC is most likely going to issue a shelter in place order.

quote:

The City That Never Sleeps could be shutting down in 48 hours.
New York City Mayor Bill de Blasio said Tuesday that he was considering whether to impose a shelter in place order which would essentially require residents to stay in their homes and keep outside social contact to a minimum to slow the spread of the coronavirus in the nation's largest city



LINK
This post was edited on 3/17/20 at 2:36 pm
Posted by MadDogs
Member since Jul 2018
454 posts
Posted on 3/17/20 at 2:42 pm to
quote:

It showed promise in the first case of COVID in Washington but the patient was a healthy 30 year old. They have alot to prove with further testing. The good news is we know it’s safe.

It was also used fairly extensively in China. It has shown enough promise that they are attempting to patent it for treating COVID-19 even though Gilead owns the rights to it. They claim to have also begun manufacturing it.
remdesivir
Posted by 1999
Where I be
Member since Oct 2009
33655 posts
Posted on 3/17/20 at 2:43 pm to
In America most med students on clinical rotations have been sent home for online learning. Would have to get insanely bad for that to happen here.
This post was edited on 3/17/20 at 2:44 pm
Posted by AUdietitian04
In the kitchen makin you a sammich
Member since Sep 2013
64 posts
Posted on 3/17/20 at 2:43 pm to
My 70yo parents are both on Hydroxychloroquine 200 mg 2x a day for Rheumatoid Arthritis maintenance. Is there any indication that it may have any kind of preventative effect for this virus? Just curious i really worry about them, their health is total shite.
Posted by S1C EM
Athens, GA
Member since Nov 2007
11594 posts
Posted on 3/17/20 at 2:52 pm to
quote:

My 70yo parents are both on Hydroxychloroquine 200 mg 2x a day for Rheumatoid Arthritis maintenance. Is there any indication that it may have any kind of preventative effect for this virus? Just curious i really worry about them, their health is total shite


I've seen a couple of sources saying that it has been shown effective as a prophylactic, yes.
Posted by Stevo
Baton Rouge
Member since Sep 2004
12492 posts
Posted on 3/17/20 at 2:54 pm to
LINK

Per The Advocate, Baton Rouge General tested 400 patients for Covid-19 in first two days of operation. Will be interesting to see data.
This post was edited on 3/17/20 at 2:55 pm
Posted by tigerskin
Member since Nov 2004
46740 posts
Posted on 3/17/20 at 2:58 pm to
“Was just on television discussing HCQ, first well controlled study against COVID-19.

600 mg HCQ per day after 6 days, 90% of patients tested COVID-19 negative. 96% of control group tested positive after 6 days.

DM or grigano1@jhu.edu”

LINK

Posted by TDsngumbo
Member since Oct 2011
50809 posts
Posted on 3/17/20 at 2:59 pm to
If current percentages are a good indicator, we could expect roughly 149 positives from that.
Posted by heatom2
At the plant, baw.
Member since Nov 2010
13093 posts
Posted on 3/17/20 at 3:02 pm to
quote:

“Was just on television discussing HCQ, first well controlled study against COVID-19.

600 mg HCQ per day after 6 days, 90% of patients tested COVID-19 negative. 96% of control group tested positive after 6 days.

DM or grigano1@jhu.edu”


This seems almost too good to be true. But man I hope this leads to a big breakthrough.
Posted by S1C EM
Athens, GA
Member since Nov 2007
11594 posts
Posted on 3/17/20 at 3:03 pm to
Can anyone explain how an immunosuppressive drug helps fight a virus? It's counterintuitive as I think about it....
Posted by IAmNERD
Member since May 2017
24251 posts
Posted on 3/17/20 at 3:06 pm to
LINK
I saw this earlier when someone mentioned Remdesivir. This is some preprint study done on a group of 12 Covid-19 patients. I know it's really small and other groups have had some promising data on it. My question for the medical people in here is do you guys have any reservations with something like this being rushed out so fast about the safety of it? What kind of consequences could something like elevated liver enzymes that they're observing have on someone? Is this a totally new medicine?

quote:

Early Results Dampen Outlook for Experimental COVID-19 Treatment

quote:

Preliminary problems

A paper describing the first 12 patients with COVID-19 in the U.S. started circulating ahead of an official peer review, and it doesn't look great for remdesivir. While the paper didn't have anything negative to say about efficacy, there were some unsettling safety signals

quote:

All three patients treated with remdesivir recovered, but they also reported significant gastrointestinal symptoms. Investigators also noticed elevated liver enzyme levels in their blood samples.

Given the lack of available virus-attacking treatments for COVID-19, some gastrointestinal discomfort isn't such a big deal, but elevated liver enzymes could nail remdesivir's coffin shut.

Also, this was only given to 3 patients, so I'm not sure why this was even put out. I guess it could be good for other researchers to at least be aware that it's been observed? Idk, but I'm glad others are having some success with it and hopefully someone can figure it out to start work on something that's safe and can give patients some sort of hope for a little relief.
Posted by JonTigerFan11
Member since May 2016
892 posts
Posted on 3/17/20 at 3:06 pm to
Posting again about this, I am on Humira. Am I fricked?
Posted by wdhalgren
Member since May 2013
5331 posts
Posted on 3/17/20 at 3:07 pm to
I've read that it has direct antiviral effects. Not sure what is the exact mechanism of action.
Posted by tigerskin
Member since Nov 2004
46740 posts
Posted on 3/17/20 at 3:07 pm to
Jefferson Davis Parish with nighttime curfew. Not sure what to make of that.

“Parish Wide Curfew will begin on Wednesday March 18, 2020 at 11:00 p.m., in accordance with the Louisiana Revised Statute 29:724. The curfew will be in effect from 11:00 p.m. thru 5:00 a.m. until further notice. Parish wide curfew excludes persons traveling to or from work or an emergency. “

LINK
This post was edited on 3/17/20 at 3:11 pm
Posted by JohnnyKilroy
Cajun Navy Vice Admiral
Member since Oct 2012
41130 posts
Posted on 3/17/20 at 3:08 pm to
Jefferson Davis parish. Not Jefferson parish
Posted by Havoc
Member since Nov 2015
39285 posts
Posted on 3/17/20 at 3:10 pm to
Hearing some really bad news about school closures. Don’t even want to repeat it yet although the source was bonafide and certain. I just want it to be wrong.
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