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re: Coronavirus Disease 2019 (COVID-19) ***W.H.O. DECLARES A GLOBAL PANDEMIC***
Posted on 3/10/20 at 6:44 pm to SaintsandTigers
Posted on 3/10/20 at 6:44 pm to SaintsandTigers
From seeking alpha:
Generic anti-malarial may treat COVID-19 - Raymond James
Mar. 10, 2020 6:23 PM ET|About: AbbVie Inc. (ABBV)|By: Jason Aycock, SA News Editor
A generic drug used to treat malaria may be as promising as any that companies are currently scrambling for to treat COVID-19, the coronavirus-related disease spreading rapidly, Raymond James says.
Analyst Steven Seedhouse says chloroquine - a longtime oral anti-malarial that costs pennies per dose - could turn out "more effective, scalable, and affordable" than the candidates being studied by companies including AbbVie (NYSE:ABBV), Gilead (NASDAQ:GILD), and Regeneron (NASDAQ:REGN), not to mention Moderna (NASDAQ:MRNA), GlaxoSmithKline (NYSE:GSK), Pfizer (NYSE:PFE) and others.
After very early indications of efficacy in China, chloroquine is seeing increased demand suggesting it may be seeing real-world use already, though ultimate efficacy depends on data that still need to be gathered.
Generic anti-malarial may treat COVID-19 - Raymond James
Mar. 10, 2020 6:23 PM ET|About: AbbVie Inc. (ABBV)|By: Jason Aycock, SA News Editor
A generic drug used to treat malaria may be as promising as any that companies are currently scrambling for to treat COVID-19, the coronavirus-related disease spreading rapidly, Raymond James says.
Analyst Steven Seedhouse says chloroquine - a longtime oral anti-malarial that costs pennies per dose - could turn out "more effective, scalable, and affordable" than the candidates being studied by companies including AbbVie (NYSE:ABBV), Gilead (NASDAQ:GILD), and Regeneron (NASDAQ:REGN), not to mention Moderna (NASDAQ:MRNA), GlaxoSmithKline (NYSE:GSK), Pfizer (NYSE:PFE) and others.
After very early indications of efficacy in China, chloroquine is seeing increased demand suggesting it may be seeing real-world use already, though ultimate efficacy depends on data that still need to be gathered.
1
Posted on 3/10/20 at 6:46 pm to frankthetank
This may have been answered somewhere in here, but of the US confirmed cases, what percentage are in hospital and what percentage are just riding it out at home?
Posted on 3/10/20 at 6:51 pm to SloaneRanger
LINK
An interview with Giacomo Grasselli is the Italian official coordinating the response in Lombardy. He said the median age was 65 but within the last 5-7 days he is seeing an increase in younger patients being admitted to ICU.
An interview with Giacomo Grasselli is the Italian official coordinating the response in Lombardy. He said the median age was 65 but within the last 5-7 days he is seeing an increase in younger patients being admitted to ICU.
Posted on 3/10/20 at 6:55 pm to TigerChief10
quote:
Italy hasn't been first world for centuries dude
Holy shite.
Is this a serious post?
Posted on 3/10/20 at 7:00 pm to Burhead
quote:Great video. Everybody needs to watch this video - no political bullshite and straight from the source.
An interview with Giacomo Grasselli is the Italian official coordinating the response in Lombardy. He said the median age was 65 but within the last 5-7 days he is seeing an increase in younger patients being admitted to ICU.
He mentions the most important thing with this virus is to limit the spread of the disease. Doesnt matter how good a health care system is, if you dont limit the spread you will be overwhelmed.
I hope its not too late for other countries.
Posted on 3/10/20 at 7:02 pm to Ronaldo Burgundiaz
quote:
Definitely not a good thing for nursing homes, assisted living facilities, and oncology clinics. These places need to be AGGRESSIVELY vetting the visitors and staff.
However, for Joe Public, the threat is not that severe. I stand by the initial prediction that this will be less deadly than H1N1 2009.
Remember median incubation period is 4-5 days. The cases in Washington have shown the virus was making the rounds there for six weeks. I don't see aisles full of dead bodies in Costco in Seattle.
What the public can do is stop acting like idiots and take precautions to protect those at high risk. As I said: nursing homes, assisted living facilities, and oncology clinics need to be AGGRESSIVELY vetting the visitors and staff.
Best response ive seen yet.
Posted on 3/10/20 at 7:05 pm to lsulaker
quote:
Chloroquine, a widely-used anti-malarial and autoimmune disease drug, has recently been reported as a potential broad-spectrum antiviral drug.8,9 Chloroquine is known to block virus infection by increasing endosomal pH required for virus/cell fusion, as well as interfering with the glycosylation of cellular receptors of SARS-CoV.10 Our time-of-addition assay demonstrated that chloroquine functioned at both entry, and at post-entry stages of the 2019-nCoV infection in Vero E6 cells (Fig. 1c, d). Besides its antiviral activity, chloroquine has an immune-modulating activity, which may synergistically enhance its antiviral effect in vivo. Chloroquine is widely distributed in the whole body, including lung, after oral administration. The EC90 value of chloroquine against the 2019-nCoV in Vero E6 cells was 6.90 µM, which can be clinically achievable as demonstrated in the plasma of rheumatoid arthritis patients who received 500 mg administration.11 Chloroquine is a cheap and a safe drug that has been used for more than 70 years and, therefore, it is potentially clinically applicable against the 2019-nCoV.
LINK
I wonder if any of the patients in China were on Chloroquine?
Since it helps block entry of virus into cells could it be possibly given to healthcare workers to reduce their risk of contracting coronavirus and continue working longer? I hope they find these answers soon.
Posted on 3/10/20 at 7:07 pm to tgr4ever
The British health minister has tested positive as well.
Posted on 3/10/20 at 7:08 pm to WaWaWeeWa
china is where a lot of the covid 19 chloroquine data are coming from. they explicitly named it in their guidelines for treatment
This post was edited on 3/10/20 at 7:09 pm
Posted on 3/10/20 at 7:11 pm to Tiguar
quote:
President Trump secures no-cost virus testing for Americans The Trump Administration is leading an “all-of-America” approach, as Vice President Mike Pence calls it, to protect Americans during the global Coronavirus outbreak.
“Last week, at this table, the President met with pharmaceutical leaders, we met with nursing home leaders, leaders of commercial labs, airline industries,” Vice President Pence said. “We’re bringing all of the businesses of the country to bear to protect the health of the American people.”
Earlier today, President Trump and the Vice President met with executives from America’s largest health insurance companies, where they announced a major deal.
Vice President Pence: We are defending all patients against surprise billing “I’m pleased to report, as you requested, Mr. President, that all the insurance companies here—either today or before today—have agreed to waive all copays on coronavirus testing and extend coverage for coronavirus treatment in all of their benefit plans,” the Vice President said. Medicare and Medicaid announced recently that beneficiaries will have Coronavirus testing and treatment covered. Now, private insurers have made that commitment, as well.
Insurers also agreed to cover telemedicine services, which will allow all patients—particularly among the vulnerable senior population—to be treated without feeling the need to go to a hospital or doctor’s office.
Whitehouse.gov
Posted on 3/10/20 at 7:12 pm to Antonio Moss
Tigerqueef10 has been proving himself to be dumber and dumber throughout this thread. He'll probably claim that he was trolling in the end to try to save face.
Posted on 3/10/20 at 7:13 pm to Tiguar
quote:
china is where a lot of the covid 19 chloroquine data are coming from. they explicitly named it in their guidelines for treatment
What are your thoughts on when it would be effective in the course of infection. I’m suspecting earlier on. If they are trying it on patients already in ARDS it may be too late. I’m hoping for some data on early usage. It would have been good to try that in SK since they were indentifying patients so early. shite, I’d take some chloroquine right now, very well studied drug.
This post was edited on 3/10/20 at 7:14 pm
Posted on 3/10/20 at 7:14 pm to WaWaWeeWa
So we finally test more? Capacity is estimated to be what about 15k/day? There was a graph earlier.
Posted on 3/10/20 at 7:17 pm to ell_13
quote:
So we finally test more? Capacity is estimated to be what about 15k/day?
Hopefully. Massive testing the best procedure for contain the spread. If you don’t know who has it, there is no way to contain it.
Posted on 3/10/20 at 7:19 pm to WaWaWeeWa
any viral infection it's better to treat early rather than late.
chloroquine and it's USA-available counterpart hydroxoychloroquine have shown to be somewhat effective in severely-ill patients with pneumonia as well as mild-cases.
protease inhibitors (kaletra + ribavirin) explicitly work to reduce viral load and really will only work in the early phases of infection.
So, I would recommended hydroxychloroquine in severe cases and the protease inihibitor 3 drug combo regimen in healthcare workers or those early in the infection process at risk for degradation.
If supplies/cost werent an issue, I would do the protease inhibitor combo in everyone testing positive to reduce transmission.
chloroquine and it's USA-available counterpart hydroxoychloroquine have shown to be somewhat effective in severely-ill patients with pneumonia as well as mild-cases.
protease inhibitors (kaletra + ribavirin) explicitly work to reduce viral load and really will only work in the early phases of infection.
So, I would recommended hydroxychloroquine in severe cases and the protease inihibitor 3 drug combo regimen in healthcare workers or those early in the infection process at risk for degradation.
If supplies/cost werent an issue, I would do the protease inhibitor combo in everyone testing positive to reduce transmission.
This post was edited on 3/10/20 at 7:21 pm
Posted on 3/10/20 at 7:20 pm to WaWaWeeWa
Huge.
Posted on 3/10/20 at 7:29 pm to Tiguar
quote:
chloroquine and it's USA-available counterpart hydroxoychloroquine have shown to be somewhat effective in severely-ill patients with pneumonia as well as mild-cases.
Source?
I’m surprised at the somewhat.
The (early) studies suggested it was the most effective of the extant drugs.
This post was edited on 3/10/20 at 7:30 pm
Posted on 3/10/20 at 7:30 pm to SaintsandTigers
quote:
Full quarantine
Our economy would be fricked beyond belief and I’m not talking stocks
Posted on 3/10/20 at 7:31 pm to ell_13
quote:
Cyber security. Lots of action there lately.
Viruses. Amirite??
Posted on 3/10/20 at 7:32 pm to Burhead
quote:
The British health minister has tested positive as well.
Are politicians getting this bc of photo-ops or something ?
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