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Message
re: Cancer breakthroughs
Posted on 8/4/25 at 8:39 am to N2cars
Posted on 8/4/25 at 8:39 am to N2cars
quote:
You got 4 upvotes.
Assuming you upvoted your own post, there are at least 3 other half-wits that post here.
Hopefully none of you reproduc
5 upvotes. When in the history of this world has money not been the priority over anything else?
2
Posted on 8/4/25 at 8:43 am to Giantkiller
My quick $0.02. Many of the great treatments you're seeing today have been around for a while. The technology is just now catching up. But every time something like CAR-T makes huge strides, a whole new wave of discovery begins. It's been extremely hopeful to see. Especially as someone who is benefiting from it.
But prevention is winning the game of survivorship. I'm not sure what to call it, but finding a solid PCP these days is a tough game. Don't waste your time studying new treatments, unless you are investing in the company. Study what makes a good PCP and find one. Find one who will discuss your family medical history, your medical history and put you in a plan that fits your personal needs. Make sure they are a constant study of what's going on in the medical world. If they "know better", they don't. They need to be curious, but cautious. I had a PCP tell me once that he was there just for my sniffles. No.
And I can't say this enough, for treatment that can save your life, a drive to Houston is not "too far".
Research your doctors not your disease.
(I have survived lymphoma since 2012 by having 2 amazing oncologists and the advancement of technology. ABVD, Stem Cell Transplant, Immunotherapy, and CAR-T)
But prevention is winning the game of survivorship. I'm not sure what to call it, but finding a solid PCP these days is a tough game. Don't waste your time studying new treatments, unless you are investing in the company. Study what makes a good PCP and find one. Find one who will discuss your family medical history, your medical history and put you in a plan that fits your personal needs. Make sure they are a constant study of what's going on in the medical world. If they "know better", they don't. They need to be curious, but cautious. I had a PCP tell me once that he was there just for my sniffles. No.
And I can't say this enough, for treatment that can save your life, a drive to Houston is not "too far".
Research your doctors not your disease.
(I have survived lymphoma since 2012 by having 2 amazing oncologists and the advancement of technology. ABVD, Stem Cell Transplant, Immunotherapy, and CAR-T)
Posted on 8/4/25 at 8:54 am to WigSplitta22
quote:And when you factor in that the American Cancer Society was founded in 1913, the same year as the Federal Reserve and the IRS, it makes one wonder.
When in the history of this world has money not been the priority over anything else?
Posted on 8/4/25 at 8:55 am to Giantkiller
Since I created this post, I've completely cut out alcohol, almost all processed foods and I exercise daily. I take ashwagandha, L-theanine, B12, D3, fish oil, a probiotic, magnesium and melatonin. I have never felt better in my entire life and I'm down 40+ pounds from my heaviest. Every day I eat apples, blueberries, bananas, etc and as many whole foods/lean meats as I can possibly find.
Will I manage to evade cancer? Who knows - but I know that doing what I've done has hopefully gotten me away from the biggest risk factors.
Have any of you done any research into biomarkers? If you can pull off a blood panel twice a year, there's scores of sites that will help you track all kinds of statistics. I've looked into a few but haven't squeezed the trigger on any of them yet.
Will I manage to evade cancer? Who knows - but I know that doing what I've done has hopefully gotten me away from the biggest risk factors.
Have any of you done any research into biomarkers? If you can pull off a blood panel twice a year, there's scores of sites that will help you track all kinds of statistics. I've looked into a few but haven't squeezed the trigger on any of them yet.
Posted on 8/4/25 at 8:56 am to WigSplitta22
If you really think "big pharma" wants to keep you with the cancer, you and your other 4 like-minded chuckleheads should volunteer at an infusion center and help out. Passing out blankets, and snacks and drinks to unfortunate folks that are ill is a great way to serve.
And maybe you'll understand what is really going on, but somehow I doubt it.
This post was edited on 8/4/25 at 9:20 am
Posted on 8/4/25 at 9:17 am to BFIV
Thanks. 
You're spot on in that different markets can have wildly different price structures, and that is true of nearly every business on the planet.
In addition, almost no one, including Medicare and insurance companies, is paying "list" price for any medication, including cancer drugs.
"Big pharma" is constantly spending huge dollars on research and development of new cancer agents, not so they can " keep you with the cancer ", but that you might live to fight another day, and maybe get to the next breakthrough.
Curing cancer is not easy because "cancer" is not a singular thing.
Cancer is a cowardly thing because it runs and hides and changes into something else.
If there is a "bad guy " in this evil war, my complaint is with insurance companies.
Oncologists spend far too much time working on routine approvals, and some ins companies drag their feet on sending approvals.
That said, BCBS has bern pretty good in my experience.
You're spot on in that different markets can have wildly different price structures, and that is true of nearly every business on the planet.
In addition, almost no one, including Medicare and insurance companies, is paying "list" price for any medication, including cancer drugs.
"Big pharma" is constantly spending huge dollars on research and development of new cancer agents, not so they can " keep you with the cancer ", but that you might live to fight another day, and maybe get to the next breakthrough.
Curing cancer is not easy because "cancer" is not a singular thing.
Cancer is a cowardly thing because it runs and hides and changes into something else.
If there is a "bad guy " in this evil war, my complaint is with insurance companies.
Oncologists spend far too much time working on routine approvals, and some ins companies drag their feet on sending approvals.
That said, BCBS has bern pretty good in my experience.
Posted on 8/4/25 at 9:34 am to N2cars
quote:
If you really think "big pharma" wants to keep you with the cancer, you and your other 4 like-minded chuckleheads should volunteer at an infusion center and help out. Passing out blankets, and snacks and drinks to unfortunate folks that are ill is a great way to serve.
You do realize why Martin Shkreli went to prison right? Or why Merck's Keytruda or Bristol Myers Squibbs Opdivo are the top money funders at those companies for drugs that are not curative instead of pumping money into one time cures like gene therapy. Or how about Novartis & Zolgensma charging 2 million per dose for a cure for SMA. It's absolutely ridiculous how unregulated this shite is and how much they take advantage of sick people. Facts are facts. Every single large pharmaceutical company has been hit with huge fines(100's of millions) for being unethical and misleading consumers. How you can argue that money is not at the forefront of the minds of these drug companies is beyond me. The US should adopt the open source medical research like other countries are doing so transparency is there and it's not a profit first system. Patents and secrecy are exempt in that world.
Posted on 8/4/25 at 9:47 am to N2cars
quote:
Big pharma" is constantly spending huge dollars on research and development of new cancer agents, not so they can " keep you with the cancer ", but that you might live to fight another day, and maybe get to the next breakthrough.
In 2024 alone cancer drug R&D accounted for about 35-40% of all pharmaceutical development spending with only 5 % percent of that on curative therapies
Posted on 8/4/25 at 9:51 am to Giantkiller
quote:
even curable than ever before.
As a survivor, not sure curable is correct…
Posted on 8/4/25 at 9:56 am to el Gaucho
quote:
quote:
Smoking causes cancer Alcohol causes cancer
Back in the 40s when everybody smoked and drank nobody got cancer
Because they died of heart disease before they could get cancer. Not to mention pneumonia and all the other diseases and disorders we blow off nowadays. Hell, people were dying of gallstone and kidney stone complications back then, which almost never happens now. Gotta survive long enough to get cancer.
Posted on 8/4/25 at 10:11 am to WigSplitta22
Cite it.
Posted on 8/4/25 at 10:13 am to WigSplitta22
Here's one for you: a close friend of the family had colon cancer. Long story short, she was able to procure a new drug that hadn't been named yet from outside the U.S. that cured her cancer.
Let me say that again...it CURED her cancer. That was 30 years ago and she still lives today cancer free.
What happened to that drug? Nobody knows. It was never named and is nowhere to be found.
You'd think a drug that CURED cancer would be known and available worldwide.
Let me say that again...it CURED her cancer. That was 30 years ago and she still lives today cancer free.
What happened to that drug? Nobody knows. It was never named and is nowhere to be found.
You'd think a drug that CURED cancer would be known and available worldwide.
Posted on 8/4/25 at 11:13 am to N2cars
quote:
Cite it.
Those are estimated percentages from data collected in the industry as a whole
LINK
Within this research, the majority of trials are incremental improvements or life extending treatments, not definitive cures.
quote:
Approximately two-thirds of medical oncologists receive industry payments each year,and receive a substantially greater dollar value of industry money than most other specialties. This amount has increased, and more oncologists now receive greater dollar amounts from industry than in the recent past. Research suggests that concerns about the influence on care delivery may be warranted in oncology as well; for example, receipt of industry money is associated with increased prescribing of nilotinib over imatinib for the treatment of chronic myeloid leukemia, despite nilotinib’s greater financial cost and higher incidence of serious toxicities.
LINK
quote:
Findings
In this cohort study of 298 RCTs, progression-free survival was the predominant end point of oncology RCTs, and median survival gains remain modest. Almost all RCTs are now funded by industry; this is accompanied by a substantial increase in use of professional medical writers.
quote:
Sixty-nine percent (206 of 298) of RCTs were of palliative intent.
Posted on 8/4/25 at 11:25 am to WigSplitta22
You can't use OS as the endpoint for every trial because it would take decades to complete.
That's why PFS is used. Typically, OS is included as a secondary objective. Did the research you looked up break down anything about the secondary objectives?
Furthermore, patients in trials typically are already on their 3rd or 4th line of treatment, and these patients have a very low survival times already. You would have 100% failure rate for these trials if OS, i.e., curing the patient, was the primary endpoint.
So much ignorance is put on display by home-office scientists in threads like these.
That's why PFS is used. Typically, OS is included as a secondary objective. Did the research you looked up break down anything about the secondary objectives?
Furthermore, patients in trials typically are already on their 3rd or 4th line of treatment, and these patients have a very low survival times already. You would have 100% failure rate for these trials if OS, i.e., curing the patient, was the primary endpoint.
So much ignorance is put on display by home-office scientists in threads like these.
Posted on 8/4/25 at 11:33 am to WigSplitta22
Missing the 5% part from both those links....
Posted on 8/4/25 at 12:36 pm to WigSplitta22
Excellent source.
quote:
High Investment Levels: Pharma R&D is supported by significant funding. Overall funding reached $102 billion in 2024 (up from $71 billion in 2023), a decade high. 1 This fuels global R&D spending, recorded at $163 billion in 2023 and estimated at $190 billion for 2024. 1
US and China Lead: R&D activity is geographically concentrated. The US hosts approximately 55% of R&D headquarters,3 while China hosts approximately 14%, 12 making it the second highest, and is rapidly growing as a major R&D center.
Focus Areas: Investment is heavily directed towards oncology (anticancer research) and biotechnology, representing significant shares of the R&D landscape (approximately 23% and 22% respectively) and showing growth rates around 3% each in the recent 5 years. 2
Posted on 8/4/25 at 12:37 pm to castorinho
quote:
Missing the 5% part from both those links
Yep.
Posted on 8/4/25 at 12:40 pm to N2cars
Breast cancer in particular has seen phenomenally better outcomes since the 1990s.
If you're looking for a staight-up cancer cure, I dont know if you'll ever see it (in our lifetime).
Posted on 8/4/25 at 12:43 pm to WigSplitta22
quote:
Sixty-nine percent (206 of 298) of RCTs were of palliative intent.
Do you know what palliative care is?
Posted on 8/4/25 at 1:01 pm to N2cars
Talking to an NP I know,she works for a PCP.She told me a patient of theirs has lung cancer, is taking chemo but wasn’t responding to it.
Patient started taking ivermectin on her own,didn’t tell her oncologist.Her tumors are shrinking and her breathing is better.
I’v read these stories but first one I’ve heard locally from someone I know.
Patient started taking ivermectin on her own,didn’t tell her oncologist.Her tumors are shrinking and her breathing is better.
I’v read these stories but first one I’ve heard locally from someone I know.
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