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Virta - anti-diabetes startup makes huge announcement

Posted on 2/11/18 at 11:35 pm
Posted by Big Scrub TX
Member since Dec 2013
39859 posts
Posted on 2/11/18 at 11:35 pm
Virta is a startup founded last year with the goal of using diet (you guessed it - keto or some low-carb variant) and an app to reverse 100 million people out of Type 2 Diabetes by 2025.

They have an ongoing clinical trial that has been announcing results and they are astounding:
quote:


94 percent of patients who were on insulin, using the Virta mobile tool, and altering their diet decreased or eliminated their insulin dosage by the end of the year.


quote:

A total of 349 Type 2 diabetes patients enrolled in the study, which was unblined and allowed participants to opt in or out of the treatment options. In the study 262 decided to be part of the intervention group participated in Virta’s remote monitoring app and nutritional ketosis, which is a special diet that requires moderating protein consumption and reducing carbohydrates.


quote:

After a year, patients in the intervention group lost an average of 12 percent of their body weight. The group also lowered their average HbA1c from 7.6 percent to 6.3 percent. Meanwhile, the 87 patients that did not receive interventions had no change in HbA1c, weight, or diabetes medicine over the year, according to the study.


LINK

quote:

today announced the peer-reviewed publication of 1-year results from its ongoing clinical trial, now 2.5 years in duration. The study augments Virta Health’s existing body of peer-reviewed research, which proved that the Virta Treatment could systematically reverse type 2 diabetes in as little as 10 weeks. Newly released data demonstrates that diabetes reversal rates are sustained and in fact improved at one year, while metrics of other chronic conditions, such as obesity, blood pressure, cardiovascular disease and inflammation, are also substantially improved.


quote:

results go beyond blood sugar and obesity reduction and included the following statistically significant changes:

24 percent decrease in triglycerides
18 percent increase in HDL-C (i.e. ‘good’ cholesterol)
39 percent decrease in C-reactive protein (a marker of inflammation)
Decrease in both systolic and diastolic blood pressure


LINK

This should be the biggest news in the country right now, but the usual suspects have a vested interest in not trumpeting it. Expect MANY more actual clinical trials around low-carb diets to show in the coming decade what we pretty much already know: almost all varieties of American unhealthiness stem from over-consumption of carbs.

The diet we've been preached for the past 50 years is literally the opposite of what we need for health.

Start keeping this in mind the next 500 times you are urged to up your intake of "healthy grains."

Even better link from the company: LINK
This post was edited on 2/12/18 at 3:10 pm
Posted by MF Doom
I'm only Joshin'
Member since Oct 2008
11937 posts
Posted on 2/11/18 at 11:49 pm to
Really interesting stuff.

One day we're gonna look at all this sugar consumption the same way we look at smoking
Posted by prplhze2000
Parts Unknown
Member since Jan 2007
58200 posts
Posted on 2/12/18 at 5:45 am to
Karl Denninger has been preaching this stuff on the Market Ticker for a couple of years now. Main. Thing is reduce the carbs, cut out the sugars, pretty much a south beach diet of sorts, and you can get off the meds for type 2.
Posted by McLemore
Member since Dec 2003
35330 posts
Posted on 2/12/18 at 6:32 am to
You either have a downvote stalker or there's a radical vegan lurking 'round here (not mutually exclusive by any means). This is awesome. Volek and Phinney were developing an app, but I haven't heard much about it lately. I wonder if they sort or let it go due to this huge endeavor.
This post was edited on 2/12/18 at 6:33 am
Posted by prplhze2000
Parts Unknown
Member since Jan 2007
58200 posts
Posted on 2/12/18 at 8:19 am to
ADA is not going to like it. They tell people on their website to make sure 25% of their daily diet is grains and starches.
Posted by Hu_Flung_Pu
Central, LA
Member since Jan 2013
22543 posts
Posted on 2/12/18 at 9:12 am to
I might get downvoted but I believe that non-athletes (not training for a competition) should not have carbs or very little.
Posted by LSUAlum2001
Stavro Mueller Beta
Member since Aug 2003
48573 posts
Posted on 2/12/18 at 9:24 am to
The diet plan I used heading into Wodapalooza was ~100g total in carbs with a max of 40g sugar (basically one can of Coke) per day.

High protein, high fat, and the only time I was supposed to consume carbs was before working out or on a carb load day, but most of that was in the form of sweet potates or similar carb.

I slacked a little since, but I’ll be switching back to it soon.
This post was edited on 2/12/18 at 9:27 am
Posted by Big Scrub TX
Member since Dec 2013
39859 posts
Posted on 2/12/18 at 1:16 pm to
quote:

Volek and Phinney were developing an app, but I haven't heard much about it lately. I wonder if they sort or let it go due to this huge endeavor.


I believe the are co-founders of Virta.
Posted by Big Scrub TX
Member since Dec 2013
39859 posts
Posted on 2/12/18 at 1:16 pm to
quote:

I might get downvoted but I believe that non-athletes (not training for a competition) should not have carbs or very little.
Athletes don't need them either.
Posted by Hu_Flung_Pu
Central, LA
Member since Jan 2013
22543 posts
Posted on 2/12/18 at 1:40 pm to
I disagree. You can only get peak performance with carbs. I know you can perform well on low carbs but not the best.
Posted by nvcowboyfan
James Turner Street, Birmingham,UK
Member since Nov 2007
2992 posts
Posted on 2/12/18 at 1:55 pm to
Interesting but not earth-shattering. I see type II diabetics every day. My first intervention before meds is to fix their diet by cutting way down on carbs. Every so often I'll have someone who does it and is able to get off their meds, but unfortunately the vast majority of the time they won't do it.
Had a 350 pound heifer newly diagnosed with type II - a1c of 7.5. I asked if she wanted to try a strict diet and exercise plan and outlined the type of food she should be eating (higher protein and fat and lower carbs, e.g. steak and broccoli or spinach salad with chicken, etc.)
her response was "that's not real food", and "if I can't eat pizza and bread I won't do it"

the diabetes and obesity epidemic won't be getting any smaller folks.
as for this app - it is a smart idea to package up what many advise
Posted by LSUAlum2001
Stavro Mueller Beta
Member since Aug 2003
48573 posts
Posted on 2/12/18 at 2:38 pm to
quote:

Had a 350 pound heifer newly diagnosed with type II - a1c of 7.5. I asked if she wanted to try a strict diet and exercise plan and outlined the type of food she should be eating (higher protein and fat and lower carbs, e.g. steak and broccoli or spinach salad with chicken, etc.) her response was "that's not real food", and "if I can't eat pizza and bread I won't do it"


Another example of why we have skyrocketing health care cost.

Should I have to pay more because of her bad choices?
Posted by Big Scrub TX
Member since Dec 2013
39859 posts
Posted on 2/12/18 at 3:05 pm to
quote:

You can only get peak performance with carbs.
This simply isn't true. It's potentially true that for extreme types of finishing activities (think a UFC fighter who has to make a big burst when he is already on his last legs) that a bump of sugar will enable them to do that. But so will PEDs...which is how I think people should think of sugar: literally, a potentially performance enhancing drug. It is not nutritionally necessary, however.
Posted by Big Scrub TX
Member since Dec 2013
39859 posts
Posted on 2/12/18 at 3:07 pm to
quote:

Interesting but not earth-shattering.
I'm happy that you are already so casually acquainted with the subject matter as an MD, but from the perspective of the average observer, it is quite earth-shattering. The average patient is not being told that diet will get them off of insulin and possibly reverse them out of the condition altogether. Much more often, in fact, they are being still prescribed a preposterous diet which advises things like having oatmeal with bananas on it for breakfast.
Posted by nvcowboyfan
James Turner Street, Birmingham,UK
Member since Nov 2007
2992 posts
Posted on 2/12/18 at 3:27 pm to
quote:

reposterous diet which advises things like having oatmeal with bananas on it for breakfast.


I agree that is it preposterous. I like the idea of the app, I just feel that it is not anything anyone can't do on their own. Just like a myfitnesspal that tracks your calories - if it works for you and you need it great but if you can do it on your own save your money
Posted by nvcowboyfan
James Turner Street, Birmingham,UK
Member since Nov 2007
2992 posts
Posted on 2/12/18 at 3:33 pm to
quote:

Another example of why we have skyrocketing health care cost. Should I have to pay more because of her bad choices?


A hugely valid point IMO.
Unfortunately we in the united states don't incentivize good behavior enough.
instead of the health insurance we have now that costs a shiteload and is only going to go up as the baby boomers age.
We pay a relatively small amount for car insurance - a high deductible for catastrophic events and you maintain the vehicle yourself with oil changes and maintenance.
We should offer very high deductible health insurance (3000 per person or 10000 for a family) and make the person responsible for their own health care. When something like this is in place, you are going to think twice about seeing the ER for the sniffles or asking for the mri for your one day headache. The cost to the country would go down greatly. But the biggest part would be we would then put the onus on each person to take care of themselves - and if they don't eliminate any safety nets that would pay for their bad behavior
Posted by Big Scrub TX
Member since Dec 2013
39859 posts
Posted on 2/12/18 at 3:36 pm to
quote:

I agree that is it preposterous. I like the idea of the app, I just feel that it is not anything anyone can't do on their own. Just like a myfitnesspal that tracks your calories - if it works for you and you need it great but if you can do it on your own save your money
Oh, agreed. The point of the thread wasn't the app - it was the clinical trial showing low carb is good for you. (The continual outcry against it is "there's no evidence.")
Posted by Hu_Flung_Pu
Central, LA
Member since Jan 2013
22543 posts
Posted on 2/12/18 at 3:40 pm to
quote:

literally, a potentially performance enhancing drug. It is not nutritionally necessary, however.


That's what I'm saying.
Posted by McLemore
Member since Dec 2003
35330 posts
Posted on 2/12/18 at 5:19 pm to
quote:

I disagree. You can only get peak performance with carbs. I know you can perform well on low carbs but not the best.


I'm experimenting with this, just ad hoc right now. On marathon and half-marathon distance runs, I've done MCT (pre), powdered MCT (in a hydration belt bottle), just electrolytes before and during, super starch (homemade), and nothing, while in nutritional ketosis.

The only time I ran out of gas was during the Golden Leaf Half, for which I didn't really train, wasn't altitude adjusted (10k feet), and didn't have enough calories generally. I finished but was totally spent by mile 11.

I just did 11 of 12 days of pretty intense skiing in ketosis. But I did some beer fueling for carbs. It was actually great.

Think I can get my study published? It has been beer reviewed (boooo).
Posted by KG6
Member since Aug 2009
10920 posts
Posted on 2/12/18 at 8:03 pm to
quote:

This simply isn't true. It's potentially true that for extreme types of finishing activities (think a UFC fighter who has to make a big burst when he is already on his last legs) that a bump of sugar will enable them to do that. But so will PEDs...which is how I think people should think of sugar: literally, a potentially performance enhancing drug. It is not nutritionally necessary, however.


This is just wrong. As someone who would love to be able to use purely fat stores for energy in endurance sports, even at moderate aerobic exertion levels roughly 50% of your energy comes from glycogen. And when pushing into higher metabolic zones, it's much higher.

There are studies of runners doing 10k's. Those on high carb, medium carb, and low carb diets. All athletes had a base run, then followed the diet. all increased their VO2 max. However the low carb is the only one that didn't see a performance increase in terms of time. Why....because even though his oxygen efficiency increased just like the other samples, it all went to converting fat to energy instead of tapping into glycogen which converts with much less oxygen consumption.

Endurance athletes 100% train to use fat as an energy source as much as possible. Just because they typically burn more glycogen than the body can store and absorb during the workout. But when it comes to race time, they still utilize as muh carb energy as they can. I literally had a bottle of 2400 calories of basically pure carbs for my workout this weekend. Impossible to complete without it.

And this isn't specific to endurance athletes. it's only highlighted as they tend to use more carb energy than the body can even store, so they have to focus on replinishing. Regukar athletes need it too, just they can store enough from regular meals. But if glycogen is not there, you waste oxygen making energy and therefore perform at a lower level.
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