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Study- Randomized study on effects of added fats on Cardiovascular health
Posted on 10/1/19 at 8:59 am
Posted on 10/1/19 at 8:59 am
Would like to see yall discuss this study, to me its a huge strike at the whole saturated fats are unhealthy arguement. To me it a step forward in the conversation about how important quality food is.
LINK
intro
LINK
intro
quote:
High dietary saturated fat intake is associated with higher blood concentrations of low-density lipoprotein cholesterol (LDL-C), an established risk factor for coronary heart disease. However, there is increasing interest in whether various dietary oils or fats with different fatty acid profiles such as extra virgin coconut oil may have different metabolic effects but trials have reported inconsistent results. We aimed to compare changes in blood lipid profile, weight, fat distribution and metabolic markers after four weeks consumption of 50?g daily of one of three different dietary fats, extra virgin coconut oil, butter or extra virgin olive oil, in healthy men and women in the general population.
quote:
Results LDL-C concentrations were significantly increased on butter compared with coconut oil (+0.42, 95% CI 0.19 to 0.65 mmol/L, P<0.0001) and with olive oil (+0.38, 95% CI 0.16 to 0.60 mmol/L, P<0.0001), with no differences in change of LDL-C in coconut oil compared with olive oil (-0.04, 95% CI -0.27 to 0.19 mmol/L, P=0.74). Coconut oil significantly increased HDL-C compared with butter (+0.18, 95% CI 0.06 to 0.30 mmol/L) or olive oil (+0.16, 95% CI 0.03 to 0.28 mmol/L). Butter significantly increased TC/HDL-C ratio and non-HDL-C compared with coconut oil but coconut oil did not significantly differ from olive oil for TC/HDL-C and non-HDL-C. There were no significant differences in changes in weight, BMI, central adiposity, fasting blood glucose, systolic or diastolic blood pressure among any of the three intervention groups.
quote:
Conclusions and relevance Two different dietary fats (butter and coconut oil) which are predominantly saturated fats, appear to have different effects on blood lipids compared with olive oil, a predominantly monounsaturated fat with coconut oil more comparable to olive oil with respect to LDL-C. The effects of different dietary fats on lipid profiles, metabolic markers and health outcomes may vary not just according to the general classification of their main component fatty acids as saturated or unsaturated but possibly according to different profiles in individual fatty acids, processing methods as well as the foods in which they are consumed or dietary patterns. These findings do not alter current dietary recommendations to reduce saturated fat intake in general but highlight the need for further elucidation of the more nuanced relationships between different dietary fats and health.
5
Posted on 10/1/19 at 9:04 am to lsu777
Posted on 10/1/19 at 9:23 am to lsu777
This study is interesting. I don't think anyone is recommending adding 50g of fat with no other change in diet.
I would like to see a follow up study that ran these same parameters, but cut carbohydrate intake to different levels. Say under 200, 150, 100, 50, 30-20. Then, see the affect of each fat on the same factors. Another group set would need to cut the carbs, but not add the fat.
IMO, this is a worthwhile study as a baseline understanding of 3 different base fats affects on cholesterol, but it shouldn't be used to persuade people from following a ketogeneic diet.
I would like to see a follow up study that ran these same parameters, but cut carbohydrate intake to different levels. Say under 200, 150, 100, 50, 30-20. Then, see the affect of each fat on the same factors. Another group set would need to cut the carbs, but not add the fat.
IMO, this is a worthwhile study as a baseline understanding of 3 different base fats affects on cholesterol, but it shouldn't be used to persuade people from following a ketogeneic diet.
Posted on 10/1/19 at 9:35 am to CoachChappy
quote:
IMO, this is a worthwhile study as a baseline understanding of 3 different base fats affects on cholesterol, but it shouldn't be used to persuade people from following a ketogeneic diet
Correct as they were not following a low carb or keto diet.
I would like to see a randomized study repeating this one with the following parameters
1) all participants try to eat at maintenance
2) one group eats 40/40/20
3) 2 groups repeat the MCT/evoo part of this study replacing calories from carbs with the data. Have a third group do this with grass fed butter
4) traditional keto diet
Posted on 10/1/19 at 9:40 am to lsu777
Very interesting. We don't use coconut oil right now but it would be worth looking into.
Posted on 10/1/19 at 10:10 am to lsu777
quote:
I would like to see a randomized study repeating this one with the following parameters
Any follow ups would be great. LIke I said, this is a great base study that sets the stage for further study.
My biggest fear is that charlatans like Dr. Oz are going to use this for a attention grabber headline. IS COCONUT OIL AS SAFE AS WE THOUGHT? STUDY SHOWS ADDING FAT TO YOUR DIET IS UNHEALTHY?
Posted on 10/1/19 at 10:14 am to CoachChappy
quote:
IS COCONUT OIL AS SAFE AS WE THOUGHT? STUDY SHOWS ADDING FAT TO YOUR DIET IS UNHEALTHY?
It actually shows coconut oil is extremely healthy, as is evoo, regular Butter, not so much.
quote:
Dr. Oz
I hate him so much.
Posted on 10/1/19 at 10:17 am to lsu777
quote:
It actually shows coconut oil is extremely healthy, as is evoo, regular Butter, not so much.
You and I know that, but my 68 year old mother who watches day time tv doesn't. I can already hear the phone call. Dr. Oz had something on his show about coconut oil and butter. Are you eating that?
Posted on 10/1/19 at 11:26 am to lsu777
PDF Version with data included.
Pretty cool they are looking into it. They averaged one drink per day beforehand, and nearly halved it after. Sry, I had to.
I looked into the change of TG and HDL to see if there was any meaningful change. All 3 groups raised HDL; with only coconut oil increased TG levels and the other two reduced the TG level...but all 3 groups improved their ratio overall, which is important.
It was a self report study. While looking at the fat gram intake changes between before and after, they did change the compositions of fats consumed, so even though they increased their (butter/coconut/olive oil) intake, the participants reduced other sources of fats - I'd be curious as to what those sources were.
It is a great start to finding out if saturated fats are the devil. I just don't see how they could be. Hopefully this study gets a ball rolling on clinical tests to have clearer data on the matter.
Pretty cool they are looking into it. They averaged one drink per day beforehand, and nearly halved it after
. Sry, I had to. I looked into the change of TG and HDL to see if there was any meaningful change. All 3 groups raised HDL; with only coconut oil increased TG levels and the other two reduced the TG level...but all 3 groups improved their ratio overall, which is important.
It was a self report study. While looking at the fat gram intake changes between before and after, they did change the compositions of fats consumed, so even though they increased their (butter/coconut/olive oil) intake, the participants reduced other sources of fats - I'd be curious as to what those sources were.
It is a great start to finding out if saturated fats are the devil. I just don't see how they could be. Hopefully this study gets a ball rolling on clinical tests to have clearer data on the matter.
Posted on 10/1/19 at 2:10 pm to lsu777
I can't wait for the studies on lean-mass hyper-responders and refinement of lipidology to account for low-carb diets.
Unicorn stuff I know. But without truly understanding the role of LDL in atherosclerosis, beyond correlation, it's hard to draw firm and meaningful dietary fat:health-outcome conclusions.
So we just end up with childish Twitter fights among otherwise smart and rational people. Ha.
Unicorn stuff I know. But without truly understanding the role of LDL in atherosclerosis, beyond correlation, it's hard to draw firm and meaningful dietary fat:health-outcome conclusions.
So we just end up with childish Twitter fights among otherwise smart and rational people. Ha.
Posted on 10/3/19 at 7:01 am to lsu777
No LDL-P?
Posted on 10/3/19 at 7:02 am to LSUfan20005
Don't think so, but check the study
Posted on 10/3/19 at 8:48 am to lsu777
After a dive into some things I've read in the past on saturated fats, and why I think they aren't bad. I wanted to share,
Dietary Intervention Study basically saying the same thing. They tried to replace saturated fats with omega 6 linoleic acid (terrible idea) and found the opposite of what they sought.
LINK These guys went to the unpublished data of the Minnesota Coronary Experiment (MCE). The MCE was a double blind RCT that basically did what the dietary intervention did above. They found what we already know (because MCE is an older study) that
A bit of history on the MCE...
Dietary Intervention Study basically saying the same thing. They tried to replace saturated fats with omega 6 linoleic acid (terrible idea) and found the opposite of what they sought.
LINK These guys went to the unpublished data of the Minnesota Coronary Experiment (MCE). The MCE was a double blind RCT that basically did what the dietary intervention did above. They found what we already know (because MCE is an older study) that
quote:
linoleic acid effectively lowers serum cholesterol but does not support the hypothesis that this translates to a lower risk of death from coronary heart disease or all causes.
A bit of history on the MCE...
quote:
Minnesota Coronary Experiment The Minnesota Coronary Experiment (MCE), a randomized controlled trial conducted in 1968-73, was the largest (n=9570) and perhaps the most rigorously executed dietary trial of cholesterol lowering by replacement of saturated fat with vegetable oil rich in linoleic acid. The MCE is the only such randomized controlled trial to complete postmortem assessment of coronary, aortic, and cerebrovascular atherosclerosis grade and infarct status and the only one to test the clinical effects of increasing linoleic acid in large prespecified subgroups of women and older adults.
Despite the potential importance of this trial, critical analyses prespecified by the original MCE investigators have not been previously published or considered part of the evidence base (table 1). For example, we do not yet know the effects of the serum cholesterol lowering intervention in prespecified subgroups; the association between longitudinal changes in serum cholesterol and risk of death; or the effects of the intervention on any autopsy endpoints.
Posted on 10/3/19 at 10:45 am to Junky
The Okinawa diet is heavy on pig lard.
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