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AUstar
Auburn Fan
Member since Dec 2012
13056 posts

Moderna vaccine has similar immune response to natural infection
New study published in Science. Abstract from paper:

quote:

Vaccine-specific CD4+ T cell, CD8+ T cell, binding antibody, and neutralizing antibody responses to the 25-µg Moderna mRNA-1273 vaccine were examined over 7 months post-immunization, including multiple age groups, with a particular interest in assessing whether pre-existing cross-reactive T cell memory impacts vaccine-generated immunity. Vaccine-generated spike-specific memory CD4+ T cells 6 months post-boost were comparable in quantity and quality to COVID-19 cases, including the presence of T follicular helper cells and IFN?-expressing cells. Spike-specific CD8+ T cells were generated in 88% of subjects, with equivalent memory at 6 months post-boost compared to COVID-19 cases. Lastly, subjects with pre-existing cross-reactive CD4+ T cell memory had increased CD4+ T cell and antibody responses to the vaccine, demonstrating the biological relevance of SARS-CoV-2–cross-reactive CD4+ T cells.


This paper was from Crotty et al. Crotty is a widely respected vaccine researcher at the La Jolla Institute.

They were looking specifically at T cell immunity (not antibodies) and were looking at people from Phase 1 clinical trials who took only a quarter dose of the Moderna vaccine. Even in people who took this reduced dose, the T cell immune response was strong and lasts at least 6 months, though the researchers believe immunity lasts much longer than that.

In other words, booster shots probably aren't needed. The T cells last much longer than antibodies. And considering that the official Moderna vaccine is 100 micrograms, our protection is likely stronger than the people in this study (who took 25 micrograms).

I am glad that I rolled up my sleeve and proudly took my Moderna Trump vaccine.


Cosmo
Houston Astros Fan
glassman's guest house
Member since Oct 2003
107561 posts

re: Moderna vaccine has similar immune response to natural infection
Youve come to the wrong place


AmishSamurai
USA Fan
Member since Feb 2020
1220 posts
 Online 

re: Moderna vaccine has similar immune response to natural infection
quote:


I am glad that I rolled up my sleeve and proudly took my Moderna Trump vaccine. 


I'm glad I got COVID and recovered.

Too bad I'm supposedly a second class citizen because my immune system works.


xxTIMMYxx
Member since Aug 2019
8888 posts
 Online 

re: Moderna vaccine has similar immune response to natural infection
That’s the one I got


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KTrain915
LSU Fan
Baton Rouge LA
Member since Feb 2010
254 posts

re: Moderna vaccine has similar immune response to natural infection
What about those of us who actually have had their immune system respond to the Natural infection are we good to not got a shite about these?


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Delta9
US Space Force Fan
Member since Jun 2021
177 posts

re: Moderna vaccine has similar immune response to natural infection


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Rekrul
USA Fan
Member since Feb 2007
7224 posts

re: Moderna vaccine has similar immune response to natural infection
You want a cookie or something?


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tgerb8
LSU Fan
Huntsvegas
Member since Aug 2007
4563 posts

re: Moderna vaccine has similar immune response to natural infection
quote:

I am glad that I rolled up my sleeve and proudly took my Moderna Trump vaccine


your government thanks you! please remember to report any dissenters.


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FATBOY TIGER
Valhalla
Member since Jan 2016
5174 posts
 Online 

re: Moderna vaccine has similar immune response to natural infection
Will you be Jones'n when you come off that artificial high?


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ruzil
Southeastern LA Fan
Baton Rouge
Member since Feb 2012
15122 posts
 Online 

re: Moderna vaccine has similar immune response to natural infection
If your immune system worked, wouldn’t you have not gotten covid?


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moneyg
LSU Fan
Member since Jun 2006
43546 posts
 Online 

re: Moderna vaccine has similar immune response to natural infection
quote:

Youve come to the wrong place



Am I wrong in that this information would make taking the Moderna vaccine a no-brainer over the Pfizer one?



tigerpimpbot
LA-Monroe Fan
Chairman of the Pool Board
Member since Nov 2011
60443 posts

re: Moderna vaccine has similar immune response to natural infection
quote:

I'm glad I got COVID and recovered.


Same. June 2020. Been exposed many times since. Good to go.

Have a young high schooler who wants it so she doesn’t have to quarantine if exposed. Getting the kid all set up. To each their own


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73
Statestreet
LSU Fan
Gueydan
Member since Sep 2008
11281 posts
 Online 

re: Moderna vaccine has similar immune response to natural infection
What about the moderna doses with the metallic particulate in them?


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AmishSamurai
USA Fan
Member since Feb 2020
1220 posts
 Online 

re: Moderna vaccine has similar immune response to natural infection
quote:

If your immune system worked, wouldn’t you have not gotten covid?


Who knew Spicolli posts at TD?



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philter
Chicago Cubs Fan
Member since Dec 2004
8174 posts

re: Moderna vaccine has similar immune response to natural infection
From disclosure:

quote:

Employees of Moderna collaborated on protocol development, significantly contributed to the Investigational New Drug (IND) application, and participated in weekly protocol team calls. 


quote:

Funding for the manufacture of mRNA-1273 phase 1 material was provided by the Coalition for Epidemic Preparedness Innovation (CEPI).




philter
Chicago Cubs Fan
Member since Dec 2004
8174 posts

re: Moderna vaccine has similar immune response to natural infection
Strange, look who founded CEPI:

quote:

Founders

Wellcome Trust[1][2]

Bill & Melinda Gates Foundation[1




ItNeverRains
LSU Fan
Franklin, TN
Member since Oct 2007
19859 posts

re: Moderna vaccine has similar immune response to natural infection
Sounds like Moderna is almost as good as natural antibodies. Good 2nd option for obese and immune compromised high risk individuals.


FlexDawg
Georgia Fan
Member since Jan 2018
6892 posts

re: Moderna vaccine has similar immune response to natural infection
“The new analysis relies on the database of Maccabi Healthcare Services, which enrolls about 2.5 million Israelis. The study, led by Tal Patalon and Sivan Gazit at KSM, the system’s research and innovation arm, found in two analyses that people who were vaccinated in January and February were, in June, July, and the first half of August, six to 13 times more likely to get infected than unvaccinated people who were previously infected with the coronavirus. In one analysis, comparing more than 32,000 people in the health system, the risk of developing symptomatic COVID-19 was 27 times higher among the vaccinated, and the risk of hospitalization eight times higher.”


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63
the808bass
SE Missouri Fan
The Lou
Member since Oct 2012
88927 posts

re: Moderna vaccine has similar immune response to natural infection
quote:

Am I wrong in that this information would make taking the Moderna vaccine a no-brainer over the Pfizer one?


That was already a no brainer.


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arcalades
LSU Fan
USA
Member since Feb 2014
17132 posts

re: Moderna vaccine has similar immune response to natural infection
quote:

If your immune system worked, wouldn’t you have not gotten covid?
the immune system has no way of preventing a virus from being inhaled. go to bed; wake up less stupid.


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