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Posted on 3/13/20 at 10:41 am to GumboPot
I heard a rumour that rh negative blood type people have lower levels of ace2 but can't find confirmation of this.
Anyone else hear this?
Anyone else hear this?
Posted on 3/13/20 at 10:41 am to IslandBuckeye
I didn’t say it was.
Posted on 3/13/20 at 10:43 am to thetempleowl
Did not hear that but me an my entire family are negative type O, which apparently is the most common blood type.
Posted on 3/13/20 at 10:47 am to Tiguar
Where is your ARB data from?
Posted on 3/13/20 at 10:49 am to GumboPot
quote:
Did not hear that but me an my entire family are negative type O, which apparently is the most common blood type.
I doubt that is true. I heard 85 percent of population in rh positive.
O negative is the universal donor, meaning your blood can be given to anyone.
Conversely ab positive is the universal acceptor meaning they can receive anyone's blood.
Just some dumb fact...
Posted on 3/13/20 at 10:51 am to Tiguar
quote:
ACEi like lisinopril. Those patients are doing worse.
Isn’t Lisinopril an ACE inhibitor? Seems like under the idea that less ACE is better for surviving covid-19, then lisinopril should increase survivability.
Posted on 3/13/20 at 11:01 am to IslandBuckeye
Posted on 3/13/20 at 11:05 am to Tiguar
Someone posted a paper that suggested that ace inhibitors don't effect ace2, only ace1 I'm guessing. So ace inhibitors may have no effect.
Posted on 3/13/20 at 11:05 am to MontanaTiger
ACEi inhibit the conversion of angiotensin I to angiotensin II, the neurotransmitter. Not the receptor.
Decreased levels of ATII might make cells upregulate the AT2 receptor since there is less neurotransmitter to bind to
Decreased levels of ATII might make cells upregulate the AT2 receptor since there is less neurotransmitter to bind to
This post was edited on 3/13/20 at 11:07 am
Posted on 3/13/20 at 11:10 am to GumboPot
This too was known very early on in this ordeal. I wrote a thread about this damn near a month ago.
Posted on 3/13/20 at 11:11 am to BoarEd
It's funny watching the "nothing burger" crowd join the rest of is in becoming informed now 
Posted on 3/13/20 at 11:15 am to BoarEd
quote:
This too was known very early on in this ordeal. I wrote a thread about this damn near a month ago.
Posted on 3/13/20 at 11:16 am to Tiguar
quote:
It's funny watching the "nothing burger" crowd join the rest of is in becoming informed now
It's fricking ridiculous. These people look at info brought by certain people and say, "this guy posts in that one thread. I don't agree with that one thread. Therefore, everything this guy says is bullshite."
I'll edit to link to my thread on this very subject.
Posted on 3/13/20 at 11:17 am to GumboPot
Here you go:
Pubmed search "coronavirus ace2"
And here is an example of the kind of detailed genetic variations that are known to be found in the peptidase enzyme.
Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations
The coding-region variants and eQTL variants for ACE2 in East Asian and other populations.
a Schematics of 32 coding variants in ACE2 identified in the ChinaMAP and 1KGP databases. Yellow stars indicate the nonsense variants; dots indicate the missense variants. The number of samples with hotspot variants was marked. b The distribution of hotspot missense mutations of ACE2 in different populations. The colors indicate different populations. c The distribution and the allele frequencies of representative eQTL variants for ACE2 in different populations. Pie charts depict the allele frequencies of an intron variant of ACE2 (rs4646127) in the world. Orange color denotes the frequency of alteration allele, and blue color denotes the reference allele. The allele frequencies of 15 eQTLs for ACE2 gene are shown in tables. The color gradient from blue to red indicates the increasing of allele frequencies. The allele frequencies of INDEL variant rs200781818 were annotated by the gnomAD database. EAS, East Asian; EUR, European; AFR, African; SAS, South Asian; AMR, Ad Mixed American.
Pubmed search "coronavirus ace2"
And here is an example of the kind of detailed genetic variations that are known to be found in the peptidase enzyme.
Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations
The coding-region variants and eQTL variants for ACE2 in East Asian and other populations.
a Schematics of 32 coding variants in ACE2 identified in the ChinaMAP and 1KGP databases. Yellow stars indicate the nonsense variants; dots indicate the missense variants. The number of samples with hotspot variants was marked. b The distribution of hotspot missense mutations of ACE2 in different populations. The colors indicate different populations. c The distribution and the allele frequencies of representative eQTL variants for ACE2 in different populations. Pie charts depict the allele frequencies of an intron variant of ACE2 (rs4646127) in the world. Orange color denotes the frequency of alteration allele, and blue color denotes the reference allele. The allele frequencies of 15 eQTLs for ACE2 gene are shown in tables. The color gradient from blue to red indicates the increasing of allele frequencies. The allele frequencies of INDEL variant rs200781818 were annotated by the gnomAD database. EAS, East Asian; EUR, European; AFR, African; SAS, South Asian; AMR, Ad Mixed American.
Posted on 3/13/20 at 11:17 am to BoarEd
quote:
I'll edit to link to my thread on this very subject.
I'll read it because I don't remember seeing when you posted it.
Posted on 3/13/20 at 11:20 am to GumboPot
Posted on 3/13/20 at 11:24 am to TheLSUriot
So according to that map I summarize the following:
China>East Asia>Africa>Southern Asia> America> Europe
That is from high ACE2 to low.
You can draw your own conclusions why America is higher on the ACE2 scale than Europe.
China>East Asia>Africa>Southern Asia> America> Europe
That is from high ACE2 to low.
You can draw your own conclusions why America is higher on the ACE2 scale than Europe.
Posted on 3/13/20 at 11:29 am to BoarEd
quote:
Written on February 5th. Not so much as a single reply.
You were ahead of the curve. Sometimes it takes a little longer for others to catch up.
Posted on 3/13/20 at 11:30 am to GumboPot
Not ACE2 levels; that figure is displaying allele variations between those groups. These variants may also play a part in virus interaction. Just pointing out another factor in the equation beyond basal ACE2 expression levels.
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