Organ Proteins Reveal How Aging Accelerates at 50 Years Old

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It is a warning that middle-aged people have long offered the young: ageing is not a smooth process. Now, an exhaustive analysis of how proteins change over time in different organs backs up that idea, finding that people experience an inflection point at around 50 years old, after which ageing seems to accelerate.

The study, published 25 July in Cell, also suggests that some tissues — especially blood vessels — age faster than others, and it identifies molecules that can hasten the march of time.

The findings add to mounting evidence that ageing is not linear, but is instead pockmarked by periods of rapid change.

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This tracks well with previous data, says Michael Snyder, a geneticist at the Stanford University School of Medicine in California. “It fits the idea that your hormonal and metabolic control are a big deal,” he says. “That is where some of the most profound shifts occur as people age.”

Between the ages of 45 and 55 came a turning point marked by large changes in protein levels.

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