- My Forums
- Tiger Rant
- LSU Recruiting
- SEC Rant
- Saints Talk
- Pelicans Talk
- More Sports Board
- Fantasy Sports
- Golf Board
- Soccer Board
- O-T Lounge
- Tech Board
- Home/Garden Board
- Outdoor Board
- Health/Fitness Board
- Movie/TV Board
- Book Board
- Music Board
- Political Talk
- Money Talk
- Fark Board
- Gaming Board
- Travel Board
- Food/Drink Board
- Ticket Exchange
- TD Help Board
Customize My Forums- View All Forums
- Show Left Links
- Topic Sort Options
- Trending Topics
- Recent Topics
- Active Topics
Started By
Message
re: New diabetes medications prove the OT wrong, obesity is not always a choice
Posted on 9/7/23 at 11:10 am to CAD703X
Posted on 9/7/23 at 11:10 am to CAD703X
I understand the conservation concept. It causes plateaus. But even plateaus are overcome by sticking.
It is hard, but it never fails.
Exercise with diet works 100% of the time, provided the person is disciplined.
It is hard, but it never fails.
Exercise with diet works 100% of the time, provided the person is disciplined.
1
Posted on 9/7/23 at 11:13 am to DevilDagNS
quote:
I still fail to see how this is not primarily driven by lifestyle vs. chemestry.
It's pretty obvious when you see an entire family together and all have the exact same body shape, of course it is the amount of calories they eat, this is about understanding the drive for calories created by chemistry.
There is a reason folks wanted Galileo killed, he challenged what they thought they knew.
Posted on 9/7/23 at 11:17 am to Roaad
quote:
Biology can make losing weight more difficult for some.
But if you burn more calories than you consume, you will lose weight.
That is not the case with obese people. Their gene expression has altered their metabolism.
quote:
Calorie restriction generates an overall lower metabolic rate and a gradual decline in energy expenditure to match the intake eventually. This helps to generate a metabolic rate to maintain lower body weight. At the initial phase of calorie restriction, reduction in energy intake is more drastic than energy expenditure, inducing an energy deficit and weight loss. Since energy expenditure (EE) corroborates to body mass, weight loss, in turn, decreases the EE. Over time calorie restriction regime establishes an energy intake and EE balance, reaching an energy balance with reduced body weight. This decline in EE proportionate to body mass alterations is termed metabolic adaptation.
Calorie restriction => decreased metabolism.
quote:LINK
Calorie restriction-induced slowing down of metabolic rate also limits the mitochondrial generation of reactive oxygen species (ROS). ROS is disruptive to molecular and cellular structures and functions of the body. Diminished ROS production due to the slowing down of metabolism alleviates homeostasis and functional impairments.[20] Thus, calorie restriction-induced weight loss consequently improves metabolic health and reduces oxidative damage at the cellular level, thus enhancing the quality of life and lifespan.[17]
Another challenge faced by overweight and obese individuals is the impairment of metabolic flexibility, where the body cannot switch the use of metabolic substrates depending upon the need, nutrient availability, and environmental cues.[21] Metabolic inflexibility also underpins the development of chronic health issues. Often, weight reduction regimes harness the metabolic flux to be channelized towards the use of fatty acid substrates. Thus weight loss becomes harder in patients who have developed metabolic inflexibility. During weight loss and maintenance, cellular metabolic processes such as glycolysis and fatty acid oxidation are lowered. Studies have demonstrated that cellular dysregulation of the tricarboxylic acid cycle and substrate switching between glucose and fatty acids play a role in obesity and the development of chronic disease and metabolic syndrome.[22][23] Overweight and obese people demonstrate an overall improvement in metabolic flexibility after weight loss.
Overweight and obese people have decreased metabolic flexibility which means their bodies either lowers their calorie intake or basically forces them to eat. IT took years for them to develop the decreased metaolic flexibility and it takes years of proper dieting and exercising, bariatric surgery which has its own problems associated with it, or medications that alter gene expression to restore their metabolic flexibility.
quote:
Nothing in biology can change basic physics.
Your body is 100% unable to create mass out of thin air.
Biology is not physics see above for further details.
Posted on 9/7/23 at 11:20 am to CAD703X
quote:
the OT...where NO ONE EVER EATS AT MCDONALDS
also the OT - WHY THE SHAKE MACHINE BROKE AGAIN TODAY?
The BiPolar nature of the OT!
I worked at McDonalds in the late 60's - early 70's and that cured me from eating there since.
Posted on 9/7/23 at 11:20 am to WhereisAtlanta
The amount of downvotes this thread is gettin just proves how stupid and lazy people are
I was diagnose with type 2 at age 65. 73 now and weighed 170lbs I cut carbs ate highly fat lost 20 lbs without trying.
But all you smart downvoters don’t say shite it can be done and it’s scientifically proven but y’all would rather take a pill. You still gonna be fat cause your diet won’t change
I was diagnose with type 2 at age 65. 73 now and weighed 170lbs I cut carbs ate highly fat lost 20 lbs without trying.
But all you smart downvoters don’t say shite it can be done and it’s scientifically proven but y’all would rather take a pill. You still gonna be fat cause your diet won’t change
Posted on 9/7/23 at 11:21 am to skullhawk
quote:
The amount is like a setting on a dial, or what many researchers call a “set point” or “defended fat mass.” The brain maintains the dial setting or set point by regulating how much a person eats.
The dial is fricked up due to their own food choices and over-eating.
That is one possibility. There is also the possibility that their dial was f**ked up at birth thanks to the genes they got from their fat mom and obese dad, or a combination of both? However, it does not really matter how the dial got messed up. They can't solve their obesity until their dial gets fixed. They can't just choose to fix their dial and it be fixed.
Posted on 9/7/23 at 11:24 am to ole man
quote:
You
Must be a fat arse.
Nope. BMI of 27. A little overweight but far from a fatass. A1C of 5.3% at my checkup last week and cholesterol was good too.
Posted on 9/7/23 at 11:26 am to WeeWee
FWIW, there is no drug or surgery to fix metabolism.
Posted on 9/7/23 at 11:26 am to HouseMom
quote:
Some of y'all need to read In Defense of Food by Michael Pollan. He talks about how we are killing ourselves with processed food. His mantra: "Eat food. Not too much. Mostly plants." It's an eye opening read, and I believe he has a show.
It's all so ridiculous. Americans are in this pickle not because of big pharma or big grocery - they're in it because of the insane rise of fast food.
Just drive around town and look at the lines around Cane's and Chick fil A. The calories in a Caniac are what most people need in a DAY. And they'll eat that for one meal!
Look in people's buggies at the store. People are waddling around with nothing but junk to take home.
And I truly hate the notion that healthy food is expensive. Please. You know what's expensive? Chips and soft drinks. By meat on sale and stick it in the freezer. In season fresh vegetables are dirt cheap. And what's really cheap? Seeds!! Feel free to plant some stuff if you have space. It's very easy to grow food, especially in south Louisiana.
But the truth is, you'll never hear these things from a doctor, because the vast majority of our medical industry depends on us keeping ourselves sick.
It's really very sad.
has nothign to do with the fricking food except we eat too god damn much.
Posted on 9/7/23 at 11:34 am to WeeWee
quote:
WeeWee
do you have any clue how the medicines work? you keep posting shite like its not as simple as eating less.....but thats exactly how these medicines work. If it wasnt as easy as eating less then they wouldnt work. and metabolism has been shown to only decrease when at extreme caloric restriction. what happens is NEAT(non exercise activity that causes thermogenesis aka moving around) decreases because people get tired easier on lower calories due to recovery suffering from being in a caloric deficit.
all the drugs in this class are forms of glp-1 receptor agonist that curbs appetite and controls insulin. It controls appetite by slowing gastric emptying, controlling hunger pains from insulin spikes, and suppression of the hormone ghrelin. This greatly reduces food noise.
its the opposite of the ghrh mk677 is used as the opposite, it forces the body to produce more growth hormone and ghrelin forcing underweight people to eat way more.
in general semaglutide drugs have been looked at for almost 2 decades now working their way slowly through trials. They will end up being miracle drugs. Very few side effects adn no serious sides for 99.99% of people.
also the drugs tend to punish you if you do not want to make a change in lifestyle. Want to eat sugary fatty foods....or super rich foods...medicine will have you shitting up a storm and make life miserable for you.
want to stuff yourself as fast as possible and just be a fat frick stuffing your face on things like huge plates of pasta....yea good luck with that. medicine will have you puking and shitting yourself so you stop being a dumb frick.
now if we could just get everyone to lift weights we would be good.
with all that being said, I 100% support the use of these drugs if you need it and its exactly the types of drugs big pharma should be going after in R&D.
oh and no these drugs do not burn muscle. Going into a steep caloric restriction and not eating protein while not lifting causes muscle wasting, not the drugs. there is no mechanism where the drugs can burn muscle as they cant even burn fat.
TLDR: These drugs work by curbing appetite, they dont burn muscle and most of the fat fricks of the OT should use them.
oh and everyone should be lifting heavy arse weights, no matter the age.
Posted on 9/7/23 at 11:35 am to WeeWee
quote:
I don't believe in masks unless it is a properly fitted N95. Then I only believe they work for healthcare workers and others within feet of someone with covid. However, they do work great at blocking the smell of nasty wounds, patient's BO, patient's vaginal discharge, and shite. So I always keep one in my pocket for stanky situations.
You raping people with a mask on? Sounds like the only way you can get poon
Posted on 9/7/23 at 11:35 am to WeeWee
quote:
That is one possibility. There is also the possibility that their dial was f**ked up at birth thanks to the genes they got from their fat mom and obese dad, or a combination of both? However, it does not really matter how the dial got messed up. They can't solve their obesity until their dial gets fixed. They can't just choose to fix their dial and it be fixed.
that is not how it works. its learned behavior. again you have no clue how this shite works
Posted on 9/7/23 at 11:35 am to Roaad
quote:
I understand the conservation concept. It causes plateaus. But even plateaus are overcome by sticking.
It is hard, but it never fails.
Exercise with diet works 100% of the time, provided the person is disciplined.
No it does not. In order to qualify for bariatric surgery in the USA a person has to try diet and exercise first. That means meeting with a nutritionist of dietician, logging their food intake, meeting with a personal trainer, logging their exercise, having a psychologist that works with them. They do this for 3-6 months. some people lose weight and do not need surgery. Others do not lose weight despite being disciplined and require medications. They do these for another 3-6 months and again some of those lose weight and some don't. Those that don't get bariatric surgery.
Posted on 9/7/23 at 11:36 am to WeeWee
quote:
BMI of 27. A little overweight but far from a fatass. A1C of 5.3% at my checkup last week and cholesterol was good too.
How old are you?
Never had sugar issues all till about 2 years ago. Now I am 6.5 to 7.5 since.
As stated before, as you age, gets harder to keep things where they were.
Posted on 9/7/23 at 11:37 am to WeeWee
quote:
No it does not. In order to qualify for bariatric surgery in the USA a person has to try diet and exercise first. That means meeting with a nutritionist of dietician, logging their food intake, meeting with a personal trainer, logging their exercise, having a psychologist that works with them. They do this for 3-6 months. some people lose weight and do not need surgery. Others do not lose weight despite being disciplined and require medications. They do these for another 3-6 months and again some of those lose weight and some don't. Those that don't get bariatric surgery.
they are not being disciplined. how the frick do you think bariatric surgery works? it causes them to eat less bro
same as the GLP-1 agonist. you literally have no clue and make those of us that support the use of these drugs look like morons.
just stfu already as you do not understand any of this. I dont care if you are a doctor or not or whatever you are...you are clueless when it comes to this stuff.
Posted on 9/7/23 at 11:39 am to Cheese Grits
quote:
How old are you?
Never had sugar issues all till about 2 years ago. Now I am 6.5 to 7.5 since.
As stated before, as you age, gets harder to keep things where they were.
you are wrong too. thats not how it works.
we have plenty of studies that prove this.
also you metabolism only slows about 10 calories per decade of life if muscle mass stays constant. so no your metabolism doesnt slow as you age, we just get lazy and do not move nearly as much throughout the day. dozens of studies prove that.
Posted on 9/7/23 at 11:43 am to SlowFlowPro
quote:
It's more than just an appetite suppression. It actively works to re-wire the brain to less pathological instructions, among other positive effects.
ftr SFP this is true but not true. it controls ghrelin, insulin and slows gastric emptying. this send signal to the brain that you are not hungry and gets rid of the hunger pains caused by ghrelin and insulin releases. the medicine doesnt actually affect the brain in any way directly.
it also tends to punish those who make bad chooses by giving them the shits. if you stuff yourself real fast too....will make you throw up. so it does teach learned behaviors through negative feedback but doesnt actually rewire the brain.
Posted on 9/7/23 at 11:47 am to WeeWee
It’s not entirely wrong but it’s a still a choice. The set point increases as you gain weight because it takes more calories to maintain that weight. Over time you’ve trained your brain and body to eat at that level and takes a lot of self discipline to eat less in order to lose the weight because you have to train the set point back down as you lose weight. But initially it’s hard until you start dropping lbs because you’ll feel empty
These new drugs basically help you skip that initial tough stage and after a few months you should be able to maintain that set point without the drug with a little discipline
These new drugs basically help you skip that initial tough stage and after a few months you should be able to maintain that set point without the drug with a little discipline
Posted on 9/7/23 at 11:47 am to HouseMom
quote:
You're making my point for me. People are fat because they're addicted to food.
you sounds like the idiots that like to say sugar is 7x more addicting to cocaine.....well then how come every household keeps a bag of sugar in it and people arent mainlining or sniffing that shite up their nose?
ever been around a coke addict? trust me, you arent keeping a whole bag of coke around them without them looking like a damn ghost with a their face covered in it. ever seen a sugar addict pouring cups of sugar down their throat?
stfu with the addiction BS
Posted on 9/7/23 at 11:48 am to lsu777
quote:
also you metabolism only slows about 10 calories per decade of life if muscle mass stays constant.
that is a pretty big ask for people 60+ though
our muscle mass begins to literally degrade at that age
Page 8 of 13
Popular
Back to top
Follow TigerDroppings for LSU Football News