re: Is Charity Hospital simply too large for any logical, successful redevelopment?

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The size and condition of the building is the challenge, not the location.

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This. Plus, it's not like it's stick construction filled with sheetrock and stud partition walls. It's basically all solid concrete, which makes interior walls nearly impossible to move, and this prevents new electrical, cable, internet, and gas, and water lines from being run inside of the walls. This greatly limits its re-purposing potential, or at least makes it far more expensive.