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re: Image of a virus taken by an electron microscope

Posted on 3/14/18 at 5:41 pm to
Posted by MeridianDog
Home on the range
Member since Nov 2010
14538 posts
Posted on 3/14/18 at 5:41 pm to

That is probably (looks like) a T4 macrophage.

The geometric looking top is an elongated Icosahedron (30 sided structure) and it contains the viral genetic material.

If I am right (about it being a T4), that one replicates on E.coli bacteria - specific to that organism. In liquid, it floats around until the legs touch the cell wall of the E.coli bacterium. When the legs tough,they attach and the virus squats down until the base (where the legs attach to the column, which is made out of protein molecules, constructed in a spiral molecular configuration) touches the cell wall.

There are small enzyme containing spears there (sticking out of the base) that eat a hole in the E.coli cell wall. When the hole opens up, the spiral protein column contracts (like a spring and injects the DNA fro the head, down the hollow column and into the bacterium.

The DNA interferes with the bacterium's cellular functions and takes over the metabolic genetic replication process allowing the viral DNA to replicate. Pretty quickly, several hundred T4 phages are created within the E.coil and when that happens, the cell sort of explodes, releasing the viruses into the medium where they float around until the contact another E.coli and it starts over again.

You can seed a flask of E.coli in liquid medium with a few T4 phages and within a day or so, they will wipe out every one of billions and billions of bacterial cells in the Flask. There is no hope for them, once the first phage hits the first E.coli cell.

Thanks for letting me brain dump old virology lecture material on you guys.

I know you know this. Viruses are not living creatures, They do not take in food, they do not metabolize and they do not grow. All of these need to happen if we call something alive. They are only genetic replication (chemical)machines.

This post was edited on 3/14/18 at 5:44 pm
Posted by Mahootney
Lovin' My German Footprint
Member since Sep 2008
12033 posts
Posted on 3/14/18 at 5:48 pm to
It's not biological. I for one welcome our alien reprogramming devices.
Posted by deltaland
Member since Mar 2011
97218 posts
Posted on 3/14/18 at 5:49 pm to
Looks like those Flood organism in the Halo games
Posted by MeridianDog
Home on the range
Member since Nov 2010
14538 posts
Posted on 3/14/18 at 5:50 pm to
CJ - did you do graduate research in virology?

My Thesis was titled: "A light and electron microscope study of akinite formation and germination in Anabaena flos aqua - A-37"

Anabaena is a Blue Breen Alga, commonly found in sewage ponds.

If your search engine is good enough you can find me.

My TEM work was done on this guy

Used a Hitachi SEM.

Very close to this one
This post was edited on 3/14/18 at 6:02 pm
Posted by Isabelle81
NEW ORLEANS, LA
Member since Sep 2015
2718 posts
Posted on 3/14/18 at 6:50 pm to
Kill it with fire!!!
Posted by Kentucker
Cincinnati, KY
Member since Apr 2013
19406 posts
Posted on 3/14/18 at 7:18 pm to
quote:

Viruses are not living creatures, They do not take in food, they do not metabolize and they do not grow. All of these need to happen if we call something alive.


That's a rather curt dismissal of an entity that is a fundamental player in the history of life. While it certainly occupies the unique position at the point of life and non-life, it is the ultimate parasite.

To me its ability to evolve in parallel with its prey places it firmly in the category of the living. While so-called higher life forms metabolize and grow, viruses don't need to because they can command other organisms to do that for them. As the attached article indicates, we ignore the sophistication of viruses at our peril.

Are Viruses Alive? - Scientific American

quote:

...a virus consists of nucleic acids (DNA or RNA) enclosed in a protein coat that may also shelter viral proteins involved in infection. By that description, a virus seems more like a chemistry set than an organism. But when a virus enters a cell (called a host after infection), it is far from inactive. It sheds its coat, bares its genes and induces the cell’s own replication machinery to reproduce the intruder’s DNA or RNA and manufacture more viral protein based on the instructions in the viral nucleic acid. The newly created viral bits assemble and, voilà, more virus arises, which also may infect other cells.
Posted by Isabelle81
NEW ORLEANS, LA
Member since Sep 2015
2718 posts
Posted on 3/14/18 at 7:28 pm to
Would be interesting to learn the evolution of viruses.
Posted by Methuselah
On da Riva
Member since Jan 2005
23350 posts
Posted on 3/14/18 at 9:08 pm to
So, the movie Osmosis Jones wasn't that far off?
Posted by Tyga Woods
South Central Jupiter Island, FL
Member since Sep 2016
38544 posts
Posted on 3/14/18 at 9:34 pm to
Looks like the Google AI built himself some more legs
Posted by MeridianDog
Home on the range
Member since Nov 2010
14538 posts
Posted on 3/14/18 at 9:47 pm to
Kentucker - I never said they weren't amazing in what they do, but historically, an organism must meet certain characteristics to be termed a "Living" entity. Viruses meet almost none of these requirements.

Not to say they are not incredibly engineered clusters of chemicals in order to do what they do.

They are chemical replication machines. Yes they are parasites, but viral, not living entities.

This post was edited on 3/14/18 at 9:49 pm
Posted by jennBN
Member since Jun 2010
3236 posts
Posted on 3/14/18 at 9:48 pm to
I know it is enhanced but still amazing. Imagine if we could genetically manufacture a virus that attacked only cancerous cells but left all others intact. Like chemo but without healthy cell death. Would be fricking life changing.
Posted by Kracka
Lafayette, Louisiana
Member since Aug 2004
41695 posts
Posted on 3/14/18 at 11:01 pm to
Or it could mutate and wipe out the human race.
Posted by supadave3
Houston, TX
Member since Dec 2005
31190 posts
Posted on 3/14/18 at 11:05 pm to
It’s amazing how they even look evil. Seriously, that looks like a mean motherfricker. Like a damn wasp.
Posted by PhilipMarlowe
Member since Mar 2013
21153 posts
Posted on 3/14/18 at 11:22 pm to
D. Villeneuve’s Enemy.

Posted by Lake Vegas Tiger
Lake Vegas
Member since Jun 2014
3277 posts
Posted on 3/14/18 at 11:25 pm to
This was old when I was in school (decade ago)
Posted by reo45
Member since Nov 2015
6362 posts
Posted on 3/14/18 at 11:49 pm to



Next time you have a bacterial infection raging in your rectum recognize that that size does matter.
Posted by MeridianDog
Home on the range
Member since Nov 2010
14538 posts
Posted on 3/15/18 at 12:09 am to
quote:

This was old when I was in school (decade ago)




We worked with them when I was in school 55 years ago. Somewhere in the Attic I actually have transmission electron micrographs of T2 viral particles - the wiser 1st cousin of the T4 guys. Mine aren't this good, because this one is a scanning electron micrograph that shows a lot more 3D detail then a TEM which looks more 1 dimensional.




Of course, they have been around for 1,000,000 + years so they have that going for them, too.

This post was edited on 3/15/18 at 12:23 am
Posted by biglego
San Francisco
Member since Nov 2007
80623 posts
Posted on 3/15/18 at 12:10 am to
So these things eat the E Coli? So this wicked looking thing is a good guy?
Posted by MeridianDog
Home on the range
Member since Nov 2010
14538 posts
Posted on 3/15/18 at 12:13 am to
They do no harm to mankind. They will attack the most virulent strains of E.coli.

Care to guess where you can find some of them? In your toilet water after you take a big dump. They are likely to be up inside of you right now.

Edited to add - They don't eat E.coli. They don't eat anything. They attack them, go inside of them and take over the E.coli while they are (biochemically) sucking them out to replicate.

This post was edited on 3/15/18 at 12:17 am
Posted by biglego
San Francisco
Member since Nov 2007
80623 posts
Posted on 3/15/18 at 12:17 am to
That’s pretty awesome and I’m suddenly inspired to take a dump.
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