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Keto and glioblastoma
Posted on 10/18/18 at 8:49 pm
Posted on 10/18/18 at 8:49 pm
I read a few years ago on some research about using a keto diet to slow down the growth of gliomas. Has anyone heard anything else?
Research shows that gliomas use glycogen very efficiently. I saw this link , Keto and Glioma - CURE , and read up.
Reason is that my dad has one and was operated on with success.
Research shows that gliomas use glycogen very efficiently. I saw this link , Keto and Glioma - CURE , and read up.
Reason is that my dad has one and was operated on with success.
Posted on 10/18/18 at 9:09 pm to Hu_Flung_Pu
You are correct that it is the cancer most directly tied to glucose and glutamine metabolism and doesn't thrive as well on ketones.
Thomas Seyfried is a little nutty but he's a serious scientist and leading the way re changing our approach to cancer. Has some good papers out there, including w Dom D'Agostino. And a book worth reading.
Thomas Seyfried is a little nutty but he's a serious scientist and leading the way re changing our approach to cancer. Has some good papers out there, including w Dom D'Agostino. And a book worth reading.
Posted on 10/18/18 at 9:43 pm to McLemore
quote:
Dom D'Agostino
I watched him on the Joe Rogan podcast and he seemed very knowledgeable.
Posted on 10/18/18 at 11:06 pm to Hu_Flung_Pu
What people don’t realize is that your brain needs sugar to work. Your liver stores glucose as glycogen and your body can undergo gluconeogenesis. The idea of starving the body of sugar to cure cancer is not ready for prime time. I hate seeing people fighting cancer cutting out things they enjoy based on bad literature or no literature.
Posted on 10/18/18 at 11:39 pm to TigerDL
It is on the edge of prime time.
Cancer Lives On Sugar AND...Something Else
This is by Eric Berg. He goes into the glutamine and glucose thing. Turns out ketosis + a new drug called DON is under legitimate research as a cancer cure.
Those eastern religions been saying fasting can cure ills. I think research is catching up to that, it is just tough to get money behind it since it is very hard for others to make money from not eating.
Cancer Lives On Sugar AND...Something Else
This is by Eric Berg. He goes into the glutamine and glucose thing. Turns out ketosis + a new drug called DON is under legitimate research as a cancer cure.
Those eastern religions been saying fasting can cure ills. I think research is catching up to that, it is just tough to get money behind it since it is very hard for others to make money from not eating.
Posted on 10/19/18 at 12:00 am to TigerDL
quote:
What people don’t realize is that your brain needs sugar to work. Your liver stores glucose as glycogen and your body can undergo gluconeogenesis. The idea of starving the body of sugar to cure cancer is not ready for prime time. I hate seeing people fighting cancer cutting out things they enjoy based on bad literature or no literature.
The human body can turn fats and proteins into the necessary fuel for the brain and certain organs. This had been a "knock" on keto, but constantly debunked.
Posted on 10/19/18 at 6:12 am to TigerDL
quote:
What people don’t realize is that your brain needs sugar to work.
This is misleading. Brain doesn't need a single grain of exogenous sugar/carbohydrate to thrive. But yes, gluconeogensis is (roughly) the conversion of protein and fat into the glucose your body actually needs, to supplement its primary fuel source, endogenous ketones (assuming you are in nutritional ketosis through diet and/or fasting).
Cancer is a bitch and still a mystery in many ways and can scrape up energy to survive. But the "literature" is already there and is growing on fasting (and its stem-cell etc rejuvenating functions, including autophagy and apoptosis) and ketosis (which can mimic fasting in some ways, including through feeding cells with BHB).
Fasting and ketosis are being used as adjunct therapy of course, to help make chemo more effective.
It certainly isn't as simple as "We can starve cancer," but it is real science.
And there are MANY solid health reasons for depriving yourself of sugar, along with many other harmful substances. Just because you enjoy something in the short term (including due to addiction) doesn't mean you should do it.
I agree with you though that this stuff hasn't made prime time yet. Prime time viewers are still mostly stuck consuming outmoded, outdated, obsolete, and dangerous health advice.
This post was edited on 10/19/18 at 6:16 am
Posted on 10/19/18 at 7:16 am to Hu_Flung_Pu
In my many years of listening to podcasts, I remember one about an individual that used a keto diet while on chemo. He performed a 24hr fast before he went in for chemo as he found the fast helped out dealing with the side effects of the chemo therapy. His cancer went into remission. I don't remember the exact details or type of cancer sadly. Totally anecdotal but take it for what its worth.
I really want to read this book Tripping Over The Truth: How the Metabolic Theory of Cancer Is Overturning One of Medicine's Most Entrenched Paradigms
I really want to read this book Tripping Over The Truth: How the Metabolic Theory of Cancer Is Overturning One of Medicine's Most Entrenched Paradigms
Posted on 10/19/18 at 8:12 am to Junky
It’s a great book. I listened to it on audible. I will need to listen over again as I don’t retain as much with audiobooks, but they are convenient during my hour long commute. Highly recommend. Also, check our Peter Attia’s podcast with Dom D’Agastino. Most of it was extremely technical and over my head but the last fifteen minutes provided me with a ton of useful information and made it worth the listen.
Posted on 10/19/18 at 8:51 am to Junky
There was a German study that added ketosis to the chemo to see if it helped.
The Wim Hof method has also been shown to destroy disease and it requires nothing that costs money either. Interesting times.
The Wim Hof method has also been shown to destroy disease and it requires nothing that costs money either. Interesting times.
Posted on 10/19/18 at 9:26 am to Hu_Flung_Pu
quote:Good luck to him and your family. My wife is one year out of a "successful" surgery, and has been given months to live. One of ours doctor's had a brother with one. A total of three surgeries and every experimental treatment available, and he lasted 2 years. It's a terrible, terrible tumor.
Reason is that my dad has one and was operated on with success.
Posted on 10/19/18 at 10:36 am to Hu_Flung_Pu
Posted on 10/20/18 at 6:39 am to zatetic
quote:
It is on the edge of prime time. Cancer Lives On Sugar AND...Something Else This is by Eric Berg. He goes into the glutamine and glucose thing. Turns out ketosis + a new drug called DON is under legitimate research as a cancer cure. Those eastern religions been saying fasting can cure ills. I think research is catching up to that, it is just tough to get money behind it since it is very hard for others to make money from not eating.
If you watch that video and can’t recognize that this guy is hack I don’t know what the tell you. But he is writing on a white board so it must be science. He is a chiropractor BTW.
Posted on 10/20/18 at 5:20 pm to NewOrleansBlend
quote:
If you watch that video and can’t recognize that this guy is hack I don’t know what the tell you. But he is writing on a white board so it must be science. He is a chiropractor BTW.
He is just reciting info in an easily absorbable way. I guess he would have persuaded you if he didn't use the white board. But I'm going to need to see some credentials from you, you are just some random hack on a forum for all I know.
Anyways, Hu_Flung_Pu
I was looking for at random things a week or so ago and looked into raw milk. It had some interesting history, even used heavily in sanatoriums as a treatment to a lot of ills. I haven't delved into it very much yet, but apparently the raw milk diet can have some big time benefits. I even saw the following study just today on it reducing tumors. Best of luck!
https://www.ncbi.nlm.nih.gov/pubmed/20053771
A complex of human alpha-lactalbumin and oleic acid (HAMLET) was originally isolated from human milk as a potent anticancer agent. It kills a wide range of transformed cells of various origins while leaving nontransformed healthy cells largely unaffected both in vitro and in vivo. Importantly, purified alpha-lactalbumins from other mammals form complexes with oleic acid that show biological activities similar to that of HAMLET. The mechanism by which these protein-lipid complexes kill tumor cells is, however, largely unknown. Here, we show that complex of bovine alpha-lactalbumin and oleic acid (BAMLET), the bovine counterpart of HAMLET, kills tumor cells via a mechanism involving lysosomal membrane permeabilization. BAMLET shows potent cytotoxic activity against eight cancer cell lines tested, whereas nontransformed NIH-3T3 murine embryonic fibroblasts are relatively resistant. BAMLET accumulates rapidly and specifically in the endolysosomal compartment of tumor cells and induces an early leakage of lysosomal cathepsins into the cytosol followed by the activation of the proapoptotic protein Bax. Ectopic expression of three proteins known to stabilize the lysosomal compartment, i.e. heat shock protein 70 (Hsp70), Hsp70-2, and lens epithelium-derived growth factor, confer significant protection against BAMLET-induced cell death, whereas the antiapoptotic protein Bcl-2, caspase inhibition, and autophagy inhibition fail to do so. These data indicate that BAMLET triggers lysosomal cell death pathway in cancer cells, thereby clarifying the ability of alpha-lactalbumin:oleate complexes to kill highly apoptosis-resistant tumor cells.
Posted on 10/20/18 at 6:56 pm to zatetic
I tweeted Dom D'Agostino and he pointed me to his review of Keto on the warburg effect of gliomas
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