What is the best "supergroup" in the history of music?

Velvet Revolver
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I like Asia and Audioslave for the category, but hard to argue with Cream or the Wilburys on pure talent/influence, for sure.

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That is a broad interpretation of supergroup. Do Derek And The Dominos count?

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Is Cream really a supergroup?

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yes
bruce, baker and clapton were the three kings of british blues at the time. there had never been anything like cream before

cream is the answer to the OP's question, everyone else is fighting for 2nd place

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bruce, baker and clapton were the three kings of british blues at the time

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John Mayall was the king of British blues at the time. Clapton came from his band.

Baker was highly regarded as a drummer, but Bruce was pretty much just another musician.

Highwaymen

I would say Cream but does The Dirty Mac count:

Lennon, Clapton, Richards, Mitch Mitchell

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Bruce was pretty much just another musician.

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jack bruce was a bluesbreaker
that’s where he met Eric Clapton

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jack bruce was a bluesbreaker
that’s where he met Eric Clapton

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but he didn't have Clapton's rep