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Started By
Message
Letter from FDA to physicians on acetaminophen use
Posted on 9/24/25 at 11:35 am
Posted on 9/24/25 at 11:35 am
Notice to Physicians on the Use of Acetaminophen During Pregnancy
In recent years, evidence has accumulated suggesting that the use of acetaminophen by pregnant women may be associated with an increased risk of neurological conditions such as autism and ADHD in children. Some studies have described that the risk may be most pronounced when acetaminophen is taken chronically throughout pregnancy to childbirth. These concerns may be
magnified by the fact that a very young child’s liver may still be developing and thus a child's ability to metabolize the drug may be limited.
To be clear, while an association between acetaminophen and autism has been described in many studies, a causal relationship has not been established and there are contrary studies in the
scientific literature. The association is an ongoing area of scientific debate and clinicians should be aware of the issue in their clinical decision-making, especially given that most short-termfevers in pregnant women and young children do not require medication.
In the spirit of patient safety and prudent medicine, clinicians should consider minimizing the use of acetaminophen during pregnancy for routine low-grade fevers. This consideration should also be balanced with the fact that acetaminophen is the safest over-the-counter alternative in pregnancy among all analgesics and antipyretics; aspirin and ibuprofen have well-documented
adverse impacts on the fetus.
LINK
Trump should have never been in front of the microphone
In recent years, evidence has accumulated suggesting that the use of acetaminophen by pregnant women may be associated with an increased risk of neurological conditions such as autism and ADHD in children. Some studies have described that the risk may be most pronounced when acetaminophen is taken chronically throughout pregnancy to childbirth. These concerns may be
magnified by the fact that a very young child’s liver may still be developing and thus a child's ability to metabolize the drug may be limited.
To be clear, while an association between acetaminophen and autism has been described in many studies, a causal relationship has not been established and there are contrary studies in the
scientific literature. The association is an ongoing area of scientific debate and clinicians should be aware of the issue in their clinical decision-making, especially given that most short-termfevers in pregnant women and young children do not require medication.
In the spirit of patient safety and prudent medicine, clinicians should consider minimizing the use of acetaminophen during pregnancy for routine low-grade fevers. This consideration should also be balanced with the fact that acetaminophen is the safest over-the-counter alternative in pregnancy among all analgesics and antipyretics; aspirin and ibuprofen have well-documented
adverse impacts on the fetus.
LINK
Trump should have never been in front of the microphone
This post was edited on 9/24/25 at 11:36 am
38
Posted on 9/24/25 at 11:38 am to LSUTANGERINE
quote:
Trump should have never been in front of the microphone
Holy shite. That’s really what you get from that?
I read it as - only use it when absolutely needed because there is mounting evidence it creates more issues than it solves.
Posted on 9/24/25 at 11:39 am to LSUTANGERINE
quote:
Trump should have never been in front of the microphone
you people are absolutely insane. There is a correlation, but because Trump said it you will put your babies at risk. So dumb. Posted on 9/24/25 at 11:42 am to BBONDS25
quote:
you people are absolutely insane. There is a correlation, but because Trump said it you will put your babies at risk. So dumb.
Except that the correlation disappeared when confounding variables were controlled and they were sibling controls. That is the conflicting research that they magically left out yesterday.
Posted on 9/24/25 at 11:44 am to LSUTANGERINE
quote:
Trump should have never been in front of the microphone
I disagree.
It's all over the web-i-verse, all over the news and people everywhere have JUST become aware of this BECAUSE the Mango Menace dared speak on it.
Had it been some quiet change only really known to government and doctors offices, pregnant and soon to be pregnant women would not have necessarily gotten the memo.
Agree or disagree with Trump- the message is out there for ALL to know, the era of gatekeeping knowledge on this topic is OVER.
Posted on 9/24/25 at 11:44 am to LSUTANGERINE
Are you retarded or did you not read your copy pasta?
Posted on 9/24/25 at 11:46 am to Barstools
I did read the message. And more importantly, I am familiar with the research. It was a far cry from yesterday. Yesterday, They conveniently left out the research that does not support an association, especially the one we are confounding variables were controlled, and there were sibling controls. You know, the one we are the association disappeared with those controls.
I agree with the FDA statement.
Scientific hint: if you’re not able to replicate research or associations with more rigorous controls, then the original research does not hold much weight at all
I agree with the FDA statement.
Scientific hint: if you’re not able to replicate research or associations with more rigorous controls, then the original research does not hold much weight at all
This post was edited on 9/24/25 at 11:53 am
Posted on 9/24/25 at 11:48 am to Mid Iowa Tiger
quote:
That’s really what you get from that?
quote:
I read it as - only use it when absolutely needed because there is mounting evidence it creates more issues than it solves.
JFC don't pull a hamstring making a leap like that.
Posted on 9/24/25 at 11:50 am to BBONDS25
quote:
There is a correlation
Is this your conclusion from your reading of the research, or just from what your algorithm has fed you?
Posted on 9/24/25 at 11:52 am to LSUTANGERINE
Thisnis not a “have a press conference with the president” kind of letter.
Posted on 9/24/25 at 11:53 am to LSUTANGERINE
quote:
while an association between acetaminophen and autism has been described in many studies
Ok.
quote:
a causal relationship has not been established
Interesting.
quote:
and there are contrary studies in the
scientific literature
Hey tangerine, ask any of these people who are convinced their is correlation (yet alone causation) why they choose to believe the studies that show one thing and not the others that show the opposite and you will be deafened by the silence.
Posted on 9/24/25 at 11:56 am to SallysHuman
quote:
Agree or disagree with Trump- the message is out there for ALL to know, the era of gatekeeping knowledge on this topic is OVER.
No one was gatekeeping the knowledge. It was public.
Scratch that. The knowledge that was gatekept during the press conference was the conflicting more recent and more rigorous research that showed no association.
Posted on 9/24/25 at 11:58 am to LSUTANGERINE
quote:
No one was gatekeeping the knowledge. It was public.
Regular people don't know what they don't know and the health field is NOTORIOUS for gatekeeping.
Posted on 9/24/25 at 11:58 am to onmymedicalgrind
quote:especially more recent and more rigorous research that control for confounding variables that show no association
Hey tangerine, ask any of these people who are convinced their is correlation (yet alone causation) why they choose to believe the studies that show one thing and not the others that show the opposite and you will be deafened by the silence.
. The administration knew exactly what research they were leaving out during the press conference. I will give Trump a pass, as he does not know anything about the topic. He could not even pronounce acetaminophen.
This post was edited on 9/24/25 at 11:59 am
Posted on 9/24/25 at 11:59 am to onmymedicalgrind
I'm for studying everything, all the time. Revising recommendations, etc., you guys in the medical community catch shite for that, but I respect what goes on. (i.e. Eggs are bad for you. Then they're good for you. Then the yolks are bad and the whites are good, etc.)
But, you know very well there is no way to do gold standard, placebo-controlled studies on this sort of thing.
You can't force feed pregnant women high doses of Tylenol, give others a placebo and count the autistic babies in each batch. What you CAN do is say, "Hey, there appears to be a correlation. Let's make it a standard recommendation to avoid" and see if the trends go down. I know that's not "science", but it isn't unreasonable, either.
But, you know very well there is no way to do gold standard, placebo-controlled studies on this sort of thing.
You can't force feed pregnant women high doses of Tylenol, give others a placebo and count the autistic babies in each batch. What you CAN do is say, "Hey, there appears to be a correlation. Let's make it a standard recommendation to avoid" and see if the trends go down. I know that's not "science", but it isn't unreasonable, either.
Posted on 9/24/25 at 12:00 pm to LSUTANGERINE
quote:
Except that the correlation disappeared when confounding variables were controlled and they were sibling controls. That is the conflicting research that they magically left out yesterday.
L O L
except, you know, the official Tylenol X account tweeting 7 years ago WE DO NOT RECOMMEND ANY OF OUR PRODUCTS FOR PREGNANT WOMEN
i guess tylenol doesn't understand the science either.
Posted on 9/24/25 at 12:00 pm to LSUTANGERINE
quote:
Agree or disagree with Trump- the message is out there for ALL to know, the era of gatekeeping knowledge on this topic is OVER.
Apparently the general public needs to be reminded that decisions in medicine often boil down to risk vs benefit.
Posted on 9/24/25 at 12:00 pm to LSUTANGERINE
quote:
These concerns may be
magnified by the fact that a very young child’s liver may still be developing and thus a child's ability to metabolize the drug may be limited.
This makes sense to my non-medical, but common sense mind.
Posted on 9/24/25 at 12:00 pm to onmymedicalgrind
quote:
JFC don't pull a hamstring making a leap like that.
It’s not a leap. Did you ignore this part:
quote:
The association is an ongoing area of scientific debate and clinicians should be aware of the issue in their clinical decision-making, especially given that most short-termfevers in pregnant women and young children do not require medication.
In the spirit of patient safety and prudent medicine, clinicians should consider minimizing the use of acetaminophen during pregnancy for routine low-grade fevers.
Be aware of the issue, minimize using it, all of that sounds very much like what I said - don’t use the shite unless you have to.
Posted on 9/24/25 at 12:02 pm to LSUTANGERINE
quote:
This consideration should also be balanced with the fact that acetaminophen is the safest over-the-counter alternative in pregnancy among all analgesics and antipyretics; aspirin and ibuprofen have well-documented adverse impacts on the fetus.
Tylenol MAYBE causes autism, but also fever definitely is bad for pregnancies and so are other medications to control fever.
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