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re: Weight loss drug (Semaglutide) cut major adverse cardiovascular events by 20 percent

Posted on 8/8/23 at 9:59 pm to
Posted by Basura Blanco
Member since Dec 2011
9041 posts
Posted on 8/8/23 at 9:59 pm to
quote:

After a year, I am still not on the maximum dosage. But I have had some of those side effects still with the dosage I am on


Curious, did you get it prescribed for diabetes or strictly weight loss? Have you lost weight? If so, would you trade the side effects for the benefits?
Posted by shutterspeed
MS Gulf Coast
Member since May 2007
65090 posts
Posted on 8/8/23 at 10:03 pm to
quote:

I almost died from an adverse reaction to semaglutide.


What happened to you, baw?
Posted by Asleepinthecove
Lafayette
Member since Jan 2023
1152 posts
Posted on 8/8/23 at 10:11 pm to
I am an anesthesia provider and all of these medications delay gastric emptying, putting patients at a higher risk of aspiration pneumonia. We have had patients undergoing an EGD, on this medication, with a stomach full of food. Changing the chemical structure of how the stomach digests food, has to have some adverse outcomes down the road. It’s a risk vs benefit situation with any medication. If you’re morbidly obese, your cardiac risk may be higher than any future gastric risk that may occur from some unknown medication. It will be interesting to see if there are any problems down the road.
Posted by Delacroix22
Member since Aug 2013
4107 posts
Posted on 8/8/23 at 10:12 pm to
We would literally save so much money as a country if we bought everyone in the country a gym membership and paid them like $20 a month if they went regularly.

So many people just treat their body like garbage.
Posted by AUstar
Member since Dec 2012
17677 posts
Posted on 8/8/23 at 10:16 pm to
There's another drug in trials now that they believe will be even better.

Retatrutide is causing people to lose up to 24% of their body weight in early trials (60 pounds lost on average). This is over 48 weeks. It is also effective in people with type 2 diabetes.

No phase 3 trials yet.
Posted by BawtHouse
Member since Dec 2021
389 posts
Posted on 8/8/23 at 11:22 pm to
quote:

The negative side effects will come out in a few years Nothing that works this well comes without a price


The same could have been said about aspirin and penicillin at one time. There’s a cost benefit analysis to be done on almost anything, sure. Semaglutide has been FDA approved for close to 6 years as Ozembic AFTER the approval process. So, it’s not brand new.

Some of the latest studies are show that it works on the brain’s reward center in a way that appears to be breaking addiction cycles. Many forms of addiction. Many.

I hope you are wrong in the above quoted text. You should hope for that too. We should all root for this and similar drugs(others are coming with higher rates of effectiveness).
Posted by BawtHouse
Member since Dec 2021
389 posts
Posted on 8/8/23 at 11:30 pm to
quote:

Is there any intrinsic value to the medicine itself, or is the risk reduction strictly due to weight loss?


The answer is factually “Yes”
Posted by olgoi khorkhoi
priapism survivor
Member since May 2011
15153 posts
Posted on 8/8/23 at 11:38 pm to
quote:

It’s the American way. Don’t work on yourself just pop a pill.




i'm almost 48 with several severely broken vertebrae and if I can eat clean, do squats (albeit fairly light) and work out, anyone can. People don't even try.
This post was edited on 8/8/23 at 11:39 pm
Posted by TigerIron
Member since Feb 2021
3381 posts
Posted on 8/8/23 at 11:39 pm to
quote:

The answer is factually “Yes”


quote:

Is there any intrinsic value to the medicine itself, or is the risk reduction strictly due to weight loss?


--Is that a duck, or a piano?

--The answer is factually "yes."
Posted by BawtHouse
Member since Dec 2021
389 posts
Posted on 8/8/23 at 11:40 pm to
quote:

My understanding is that unless you change your eating habits, the user will just gain the weight back if they get off. Drug companies will have a client for life which is usually the goal.


The drug fixes a hormonal imbalance in the body that causes obesity. When you stop taking the drug, the imbalance (big shocker) presents again. So, yes, the positive effects of the drug stop when you stop taking the medicine.

Continuing to think like the quoted text above is an impediment to acceptance and access.

What would you expect to occur when someone stops taking their heart disease pills? Or their insulin?

Think different.
Posted by BawtHouse
Member since Dec 2021
389 posts
Posted on 8/8/23 at 11:48 pm to
quote:

The way it was described to me is it eliminates the desire for sugar/carbs allowing a person to do an Atkins type diet very easily. This same person said they actually craved the feeling of not eating, which is mind blowing to a fatass like myself.


Nope. Not a good description at all. It decreases impulse around cravings and increases feelings of fullness. It also causes a slow down in the digestive process, which increases length of time feeling “full.”
Posted by Bubb
Member since Mar 2010
3998 posts
Posted on 8/8/23 at 11:51 pm to
quote:

I almost died from an adverse reaction to semaglutide.


Are you comfortable expanding on this with details?
Posted by olgoi khorkhoi
priapism survivor
Member since May 2011
15153 posts
Posted on 8/8/23 at 11:54 pm to
quote:

The drug fixes a hormonal imbalance




You know what causes hormonal imbalances? Sugar/artificial sweeteners and processed food.


quote:

Think different.



Eat different.
This post was edited on 8/8/23 at 11:56 pm
Posted by BawtHouse
Member since Dec 2021
389 posts
Posted on 8/9/23 at 12:00 am to
It’s both. It has intrinsic value. There are obvious secondary benefits
This post was edited on 8/9/23 at 12:06 am
Posted by Basura Blanco
Member since Dec 2011
9041 posts
Posted on 8/9/23 at 12:02 am to
quote:

My understanding is that unless you change your eating habits, the user will just gain the weight back if they get off.


quote:

When you stop taking the drug, the imbalance (big shocker) presents again. So, yes, the positive effects of the drug stop when you stop taking the medicine.


So, you agree with everything he said and then say...

quote:

Think different.


But everyone but you is the moron.
Posted by BawtHouse
Member since Dec 2021
389 posts
Posted on 8/9/23 at 12:08 am to
quote:

i'm almost 48 with several severely broken vertebrae and if I can eat clean, do squats (albeit fairly light) and work out, anyone can. People don't even try.


Herein lies a fundamental assumption that is inaccurate.

I’m happy you are healthy and able. Everyone is not like you. Doesn’t make you better or worse than anyone else. Just different.
Posted by Shiftyplus1
Regret nothing that made you smile
Member since Oct 2005
13555 posts
Posted on 8/9/23 at 12:09 am to
It'll be $100 per pill here, and $5 per pill everywhere else on Earth.
Posted by BawtHouse
Member since Dec 2021
389 posts
Posted on 8/9/23 at 12:14 am to
quote:

quote:Think different. But everyone but you is the moron.


Apologies. I didn’t mean to make you feel like a moron. Or anyone.

Think different alludes to more than just the subject at hand, but it is quite appropriate. The theory that people’s inability to overcome the disease of obesity is rooted in will power is now known to be inaccurate. The disease is more similar to diabetes and heart disease. I guess it just isn’t as much fun for people to make fun of people for having those diseases.
Posted by krewerider
Member since Sep 2009
468 posts
Posted on 8/9/23 at 12:25 am to
I've taken the shot for 10 weeks and have lost 40 lbs. No problems or side effects for me.
I eat very small meals, appetite just isn't there. No desire for sugar at all.
Everyone's body is different though and results very.
Posted by jaytothen
Member since Jan 2020
6703 posts
Posted on 8/9/23 at 12:26 am to
quote:

And if people actually lose weight with it, then it sounds like a major breakthrough.


Know what else is a major breakthrough to lose weight?

Stop eating shite processed food and walk every now and then.
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