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Started By
Message
Weight loss drug (Semaglutide) cut major adverse cardiovascular events by 20 percent
Posted on 8/8/23 at 8:35 pm
Posted on 8/8/23 at 8:35 pm
in study
Will half the country be on it when production catches up?
“The popular but expensive weight-loss drug, semaglutide (Wegovy), significantly reduced major adverse cardiovascular events (MACE) by 20% when given to patients, compared with those receiving placebo, in the pivotal SELECT trial, with more than 17,000 enrolled people with overweight or obesity and established cardiovascular disease (CVD), but no diabetes.
The finding should fuel improved patient access to this glucagon-like peptide-1 (GLP-1) agonist weight-loss agent that has historically been hindered by skepticism among US payers, many of whom have criticized the health benefits and cost effectiveness of this drug in people whose only indication for treatment is overweight or obesity.“
LINK
Will half the country be on it when production catches up?
“The popular but expensive weight-loss drug, semaglutide (Wegovy), significantly reduced major adverse cardiovascular events (MACE) by 20% when given to patients, compared with those receiving placebo, in the pivotal SELECT trial, with more than 17,000 enrolled people with overweight or obesity and established cardiovascular disease (CVD), but no diabetes.
The finding should fuel improved patient access to this glucagon-like peptide-1 (GLP-1) agonist weight-loss agent that has historically been hindered by skepticism among US payers, many of whom have criticized the health benefits and cost effectiveness of this drug in people whose only indication for treatment is overweight or obesity.“
LINK
This post was edited on 8/8/23 at 8:36 pm
33
Posted on 8/8/23 at 8:36 pm to tigerskin
The negative side effects will come out in a few years
Nothing that works this well comes without a price
Nothing that works this well comes without a price
Posted on 8/8/23 at 8:37 pm to tigerskin
It’s the American way. Don’t work on yourself just pop a pill.
Posted on 8/8/23 at 8:39 pm to Cosmo
Yeah have read that people get back to their eating ways when get off it. The question will be will whatever side effects they find be worth staying on it like a blood pressure pill
Posted on 8/8/23 at 8:41 pm to Cosmo
quote:
The negative side effects will come out in a few years
Nothing that works this well comes without a price
I am cynical about it, too. Just seems like such a shock to the system there has to be major side effects
Posted on 8/8/23 at 8:45 pm to Cosmo
quote:
The negative side effects will come out in a few years Nothing that works this well comes without a price
For most people, those side effects will likely pale in comparison to the side effects of being obese.
Posted on 8/8/23 at 8:47 pm to tigerskin
While there are always side effects, how do they stack up against someone losing 30 or 50 lbs? That's a pretty damn big health benefit.
Posted on 8/8/23 at 8:49 pm to jbgleason
quote:
While there are always side effects, how do they stack up against someone losing 30 or 50 lbs? That's a pretty damn big health benefit.
I agree. If losing a lot of weight helps the person become more motivated to change their lifestyle and habits to help keep it off after they stop taking the injection, I don't see why anyone should be against it.
Posted on 8/8/23 at 8:51 pm to tigerskin
This gives me pause though:
SELECT is sponsored by Novo Nordisk, the company that markets semaglutide (Wegovy). Sattar is a consultant to several companies that market GLP-1 receptor agonists, including Novo Nordisk and Lilly, but has had no involvement in SELECT.
SELECT is sponsored by Novo Nordisk, the company that markets semaglutide (Wegovy). Sattar is a consultant to several companies that market GLP-1 receptor agonists, including Novo Nordisk and Lilly, but has had no involvement in SELECT.
Posted on 8/8/23 at 8:53 pm to tigerskin
I almost died from an adverse reaction to semaglutide.
Posted on 8/8/23 at 8:57 pm to tigerskin
quote:
“The popular but expensive weight-loss drug, semaglutide (Wegovy), significantly reduced major adverse cardiovascular events (MACE) by 20% when given to patients, compared with those receiving placebo,
So not being a big fatass makes you less likely to have a heart attack? Who would have ever guessed.
Posted on 8/8/23 at 9:02 pm to Cosmo
quote:
The negative side effects will come out in a few years
Well I can tell you for a fact already what the negative effects of being morbidly obese are. 20% reduction in MACE is crazy.
Posted on 8/8/23 at 9:05 pm to tigerskin
Is this the one that makes people shite themselves or is that the other one?
Posted on 8/8/23 at 9:09 pm to tigerskin
Supposed to be CV benefits with Jardiance as well.
Posted on 8/8/23 at 9:12 pm to SlowFlowPro
quote:
quote:The negative side effects will come out in a few years Nothing that works this well comes without a price I am cynical about it, too. Just seems like such a shock to the system there has to be major side effects
My understanding is that unless you change your eating habits, the user will just gain the weight back if they get off.
Drug companies will have a client for life which is usually the goal.
Posted on 8/8/23 at 9:13 pm to tigerskin
quote:
cut major adverse cardiovascular events
Being a pure blood has the same effects
Posted on 8/8/23 at 9:13 pm to genuineLSUtiger
quote:
It’s the American way. Don’t work on yourself just pop a pill.
Inventing a pill is work enough.
Posted on 8/8/23 at 9:14 pm to Cosmo
quote:
The negative side effects will come out in a few years
Nothing that works this well comes without a price
Is this the one causing stomach paralysis?
Posted on 8/8/23 at 9:15 pm to Cosmo
quote:
Nothing that works this well comes without a price
It is expensive as hell if insurance won't cover it.
Posted on 8/8/23 at 9:16 pm to STEVED00
quote:
My understanding is that unless you change your eating habits, the user will just gain the weight back if they get off.
Well yea. That's what happens when you consume 6k calories a day.
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