Two patented, expensive "covid pills" enter late-stage 3 trials.

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...bolstering compliance

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“There’s a lot of excitement for the potential of oral agents, not just for treatment,” Hazuda says. “The other huge advantage is the use of oral therapies for prevention.”

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All that and Ivermectin will still be more effective.

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Pfizer’s PF-07321332, in combination with the HIV antiviral ritonavir

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Pfizer’s PF-07321332, in combination with the HIV antiviral ritonavir

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Commonly reported side effects of ritonavir include: asthenia, diarrhea, hypertriglyceridemia, increased gamma-glutamyl transferase, nausea, vomiting, and unpleasant taste.

Other side effects include: abdominal pain, dyspepsia, fever, hyperlipidemia, increased serum alanine aminotransferase, peripheral paresthesia, dysgeusia, and oral paresthesia.

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Coadministration of ritonavir with several classes of drugs including sedative hypnotics, antiarrhythmics, or ergot alkaloid preparations may result in potentially serious or life-threatening adverse events due to possible effects of ritonavir on the hepatic metabolism of certain drugs. Review medications taken by patients prior to prescribing ritonavir or when prescribing other medications to patients already taking ritonavir.

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Check with your doctor immediately if any of the following side effects occur while taking ritonavir: Less common Fainting feeling faint, dizzy, or lightheaded feeling of warmth or heat flushing or redness of the skin, especially on the face and neck headache sweating

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Rare
Confusion dehydration dry or itchy skin fruity mouth odor increased hunger increased thirst increased urination nausea vomiting weight loss

Incidence not known
Bloating chills constipation convulsions cough darkened urine decreased urination difficulty with breathing dry mouth fast heartbeat fever hives or welts, itching, skin rash increase in heart rate indigestion large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs loss of appetite loss of bladder control muscle spasm or jerking of all extremities noisy breathing pains in the stomach, side, or abdomen, possibly radiating to the back rapid breathing redness of the skin sudden loss of consciousness sunken eyes thirst tightness in the chest unusual tiredness or weakness wrinkled skin yellow eyes or skin

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More common
Belching burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings change in sense of taste diarrhea dizziness general feeling of discomfort or illness heartburn lack or loss of strength sleepiness or unusual drowsiness trouble sleeping weakness

Less common

Body aches or pain congestion delusions dementia difficulty with moving discouragement dryness or soreness of the throat excess air or gas in the stomach or intestines fear feeling sad or empty full feeling hoarseness increased urge to urinate during the night irritability lack of appetite loss of interest or pleasure mood or mental changes muscle pain or stiffness nervousness pain in the joints or in an unspecified location passing gas runny nose tender, swollen glands in the neck throat irritation tiredness trouble concentrating trouble swallowing voice changes waking to urinate at night

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Gastrointestinal
Pancreatitis (including some fatalities) has been reported in patients using this drug, including those who developed hypertriglyceridemia. Limit for high chemistry included amylase greater than 2 times the upper limit of normal (2 x ULN).[Ref]

Very common (10% or more):
Diarrhea (including severe with electrolyte imbalance; up to 67.9%), nausea (up to 57.4%), vomiting (up to 31.9%), upper and lower abdominal pain (up to 26.4%), dyspepsia (up to 11.5%)

Common (1% to 10%): Flatulence, gastrointestinal (GI) hemorrhage, gastroesophageal reflux disease, mouth ulcer, pancreatitis, increased amylase, constipation, circumoral paresthesia, local throat irritation

Frequency not reported: Abnormal stools, bloody diarrhea, cheilitis, colitis, dry mouth, dysphagia, eructation, esophagitis, esophageal ulcer, fecal incontinence, gastritis, gastroenteritis, GI disorder, GI symptoms, gingivitis, ileitis, ileus, melena, oral moniliasis, periodontal abscess, pseudomembranous colitis, rectal disorder, rectal hemorrhage, sialadenitis, stomatitis, tenesmus, tongue edema, ulcerative colitis[Ref]

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bolstering compliance.

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