re: NY HCQ study is a joke. We are being lied to

My response was already that a seemingly paradoxical impact on mortality is generally an indicator of poor study design or "Goldilocks" effect. The point of bringing up that particular analyses wasn't use it to assert support, but rather assert this study is not the "final nail in the coffin" of hcq that the media seems to think it is.

Shell seems to have an axe to grind with this study being debunked

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True, but theres a hell of a selection bias in this study due to its observational nature.

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I will also go into detail on this since I know certain people will accuse my earlier response as a cop out.

It would make sense that overall mortality is higher in the Hcq group because there was a 40% difference in HTN prevalence and the control group is much younger.

If you look at just those who developed respiratory failure, it likely negates the recruitment bias because you probably have most of the old people/comorbid people.

ie. all the people who were at risk for deterioration, deteriorated, so the younger people without HTN in the control group are not included in the "respiratory failure" group by default.

99.6% of people under 40 are going to get better no matter what you do. The control group had 20% under 40, the tx group had 10%

"overall" statistics are almost useless in a study this bias.

My axe is with bullshite on any side of the argument. As I've already stated, the only thing this study shows is:

1) That we need randomized, controlled trials and
2) That the physicians at the hospital under study have a bias in who they are treating with HCQ.

I do not believe you can make any conclusions regarding the safety or efficacy of HCQ based on this study.

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I do not believe you can make any conclusions regarding the safety or efficacy of HCQ based on this study.

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And basically you can say that about any “study” conducted in the USA at this time. Academia has a huge liberal bias and I submit it is condescendingly showing. I am more readiy to believe the data coming in from France because they are not caught up in “OMB, must prove him wrong at any cost” and they are implementing the drugs much earlier (prior to intubation) which was the Initial intent....but due to politics/fear physicians are waiting until it is too late.

Groups running many of these trials are companies trying to get their drugs through as a treatment. That doesn't bode well if an already available, generic and cheap treatment option that works exists.

Thus, they all rig their studies and its pathetic. It's embarrassing to be linked to that industry sometimes.

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Gilead is one of the groups that ran trials on HCQ

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link?