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re: New to the Forum, any other biotech guys on here????

Posted on 8/12/15 at 3:36 pm to
Posted by Iosh
Bureau of Interstellar Immigration
Member since Dec 2012
18941 posts
Posted on 8/12/15 at 3:36 pm to
quote:

in 30 years no gene therapy ever worked on humans
w h a t
Posted by Iosh
Bureau of Interstellar Immigration
Member since Dec 2012
18941 posts
Posted on 8/12/15 at 3:38 pm to
Like gene therapy was working on humans in the 1990s, the trick is getting it to work consistently and without side effects

A bar which "this press release says four kids are doing jim-dandy!" doesn't clear
Posted by lsutraderman
USA
Member since Aug 2015
98 posts
Posted on 8/12/15 at 3:44 pm to
exactly and the bluebird beta thal patients have been transfusion free and side effect free for 18 months now, the SCD patient for 6 months now, when they update again in december we will no more. Ya of course gene therapy has worked and then people die, oddly enough all of BLUE beta thal people are transfusion free and alive thats why it boomed this year
Posted by donRANDOMnumbers
Hub City
Member since Nov 2006
17456 posts
Posted on 8/12/15 at 3:45 pm to
i am, still holding. should have gotten out when you did, or recently when it spiked. BUT I WANT IT ALL!
Posted by NaturalBeam
Member since Sep 2007
14992 posts
Posted on 8/12/15 at 4:07 pm to
This entire thread has gone over your head. I haven't read one post saying that you're wrong or that your science is wrong, evil, etc. Your reading comprehension is as bad as your people skills. You're getting hammered in this thread not for the contents of your post, but for your posting style. Just. fricking. Relax.

It's an Internet forum, there is no need for hurt feelings.
Posted by NOFOX
New Orleans
Member since Jan 2014
10128 posts
Posted on 8/12/15 at 4:15 pm to
quote:

exactly and the bluebird beta thal patients have been transfusion free and side effect free for 18 months now, the SCD patient for 6 months now, when they update again in december we will no more. Ya of course gene therapy has worked and then people die, oddly enough all of BLUE beta thal people are transfusion free and alive thats why it boomed this year


Can the therapy be adapted to more common diseases or is your enthusiasm for sickle cell treatment and other rare diseases? While medically important is the therapy for sickle cell that lucrative?
Posted by lsutraderman
USA
Member since Aug 2015
98 posts
Posted on 8/12/15 at 4:29 pm to
NOFOX finally someone wants to discuss biotechs intelligently.....thank you

1.what's interesting with bluebird is we have proof of concept in beta thal and ALD and hopefully by xmas in SCD, is SCD valuable, flat out yes, its the largest orphan indication out there. Severe SCD is what BLUE is after, the patients nearing death, and the ability to wipe SCD out of their system is nothing short of remarkable and the reason to believe it will work is bc of the success in beta thal which is a very similar disease

2.There's 70k-100k people in the US alone with SCD worldwide the numbers are bigger bc its mainly in african americans,middle easterners, etc so someone like the bill gates foundation could easily take something like this to africa, after all thats pretty much the whole mission with them, is ending african suffering

3.The lentivral success has led to the belief that multiple blood disorders could indeed be attacked, they raised at $170 recently and now have $900m in cash, they could fend off buyouts here and if the SCD is cures like the beta thal, they could realistically have cures in some monster markets and turn into a GILD type company in a few years, cures in large indications are not something that appear daily. like I mentioned GEVA was recently acquired for $8.4B which is over $200 in BLUE for a mere 5000 patients in an orphan designation, these orphan indications are worth disgusting money. Again orphan indications are my specialty, I've worked on a few orphan drugs and they're the only segment of the market I tend to have any interest in.

4.The genome editing platform bluebird has clearly works, read about CRISPR, its impossible to value this stuff its new, but this is the science you wanna be knee deep in as an investor

5.They have collaborations with CELG, prob the best large cap bio, and kite for some oncology endpoints, who knows what comes of that, but its not worthless, CELG doesn't waste time when they enter a name its for a reason hence why I mentioned XLRN earlier, thats a name CELG is already counting revenue from on 2020 slides and CELG owns 10% of.

6.The reason Im enthusiastic about bluebird is even though it ran from $17 to well over $100, yes the market cap seems nutty at $5B with no product or revenue, but the reality is they're producing cures, these people are producing hemoglobin on their own and there is reason to believe that SCD may not exist much like how sovaldi is out curing hep C for GILD. SCD is a monster market and BLUE could be a GILD like company in a few years. Who might buy a bluebird: CELG,GILD,BIIB, BMRN.....BMRN is biomarin they're a huge orphan drug company my money would be on them or GILD just bc GILD has the cash and needs some innovation to jumpstart the shares

7.Whats great with gene therapy is unlike the risks someone like GILD faces with sovaldi like generic competition, nobody in bangladesh is creating any type of gene therapy copy, this is the real deal, the holy grail really bc all other gene therapies have failed, some have solved problems but eventually side effects arise, the beta thal patients are on 18 months now with no side effects and are basically fully cured, remarkable to say the least.


thats all I said, is I wanted intelligent discussion with other intelligent bio minds on their thoughts on some of these names, I didn't want peoples opinions on whether I'm a pumper or not, I clearly could care less what anyone has to say unless its biotech related, to me most of the posters in here don't even know the first thing about what Im talking about, thats why I made a separate thread and asked for bio guys only, guys who know PE ratios and revenues don't really matter but the science and its worth does. Anyways if you have any insights on bluebird or any of the other names I mentioned, id love to discuss them further, if you have no idea what is being discussed and just want to bash me, can you please leave this thread, I'm only seeking people of value to discuss science with

Thanks again
This post was edited on 8/12/15 at 4:41 pm
Posted by NOFOX
New Orleans
Member since Jan 2014
10128 posts
Posted on 8/12/15 at 4:42 pm to
quote:

5.They have collaborations with CELG, prob the best large cap bio, and kite for some oncology endpoints, who knows what comes of that, but its not worthless, CELG doesn't waste time when they enter a name its for a reason hence why I mentioned XLRN earlier, thats a name CELG is already counting revenue from on 2020 slides and CELG owns 10% of.


Thanks for the info. Do you know why CELG recently backed out of the collaboration on the CAR T therapies research? What's your opinion on CELG's new collaborator on CAR T (JUNO)?

ETA - It looks like BLUE has good people, but not really go to guys for CARtcells relative to JUNO?
This post was edited on 8/12/15 at 4:50 pm
Posted by NaturalBeam
Member since Sep 2007
14992 posts
Posted on 8/12/15 at 4:44 pm to
quote:

I clearly could care less what anyone has to say unless its biotech related,
clearly
Posted by TigerDeBaiter
Member since Dec 2010
10728 posts
Posted on 8/12/15 at 4:48 pm to


This has been more fun than watching UVXY fly all over the place today.
Posted by lsutraderman
USA
Member since Aug 2015
98 posts
Posted on 8/12/15 at 4:49 pm to
CELG didn't back out of it all, they just ended up selecting an indication they liked the progress on and gave the rest back to BLUE. Even if 1 indication hits, thats plenty. I love JUNO its probably the next furthest along of the Car T names. Id rank them BLUE,JUNO,AGIO,KITE,BLCM.

Juno prob ends up around $15B or so in 2-3 years if not sooner, the risk off environment is just slaying bioland right now, but lots of good buys are to be had. Even BLCM the baker bros are deep in that name, and they're probably the best biotech fund out there they were on PCYC,GEVA and have tons of ANAC which just ripped 200% this month on its atopic dermatitis data. Im not a fan of BLCM but I do respect a name the baker bros like, but its the last of the CAR T names Id wanna own
Posted by NOFOX
New Orleans
Member since Jan 2014
10128 posts
Posted on 8/12/15 at 4:53 pm to
Thanks. Very interesting stuff. I will have to do some more research.
Posted by lsutraderman
USA
Member since Aug 2015
98 posts
Posted on 8/12/15 at 6:42 pm to
NOFOX you're pretty much the first and only person here who seems to know anything about CAR T and I wanted to say in more detail why I like juno. JUNO is further along than the other names, much further, and it has the best data of the CD19 cars, and maybe CELG sees something in these "armored cars" for solid tumors, and its not like they backed out they are still making some with BLUE which are solid targets imo, but obviously CELG wanted to partner up with some people a little further along in the pipeline, which is wise, this a serious game these CAR-T billions at stake here, id have to read the agreement, but CELG probably felt they were best getting into the car T space with someone with proven data, BLUE data minimal in that particular space, makes sense, again serious field, and CELG runs the blood cancer game

i also think ziop is an up and coming dark horse in that space, people disregarding but randal kirk is IMO the best scientist alive him and thomas reed and they run intrexon and have a huge stake in ZIOP, I think it may be the best when all is said and done, regardless JUNO is solid and nothing wrong with getting in in size down here this is kinda where you wanna get into the bios, when the market has gotten soft. XBI and IBB still up there but JUNO way off highs

Again,im still waiting for when the first company comes in and licenses the lentivirus for something else, and blue gaps 30% or more.....it will be nice
Posted by BioBobcat
Boston
Member since Feb 2013
854 posts
Posted on 8/12/15 at 6:55 pm to
Has anyone mentioned anything about Illumina? I own a few shares. It is on a bit of a downturn right now, but it has been good to me for the past three years. I also think Qiagen will continue to pick up steam.
This post was edited on 8/12/15 at 6:58 pm
Posted by BlueYoda
Member since Jul 2015
70 posts
Posted on 8/12/15 at 7:06 pm to
quote:

There's 70k-100k people in the US alone with SCD worldwide the numbers are bigger bc its mainly in african americans,middle easterners, etc so someone like the bill gates foundation could easily take something like this to africa, after all thats pretty much the whole mission with them, is ending african suffering


Counterpoint

Won't getting rid of the genetic protection that sickle cell provides end up killing more Africans and Middle Easterners as more will end up being more susceptible to Malaria?
Posted by Lou Pai
Member since Dec 2014
29594 posts
Posted on 8/12/15 at 8:07 pm to
Looks like I've found a new short
Posted by lsutraderman
USA
Member since Aug 2015
98 posts
Posted on 8/12/15 at 8:11 pm to
Lol good luck Lou pai I dare you to short it and document it as a long term short. Only the biggest of donkeys would short this technology with $900m in cash. Like I said short it buy puts do whatever but please post pics so I can laugh and laugh and laugh in a few months
Posted by Lou Pai
Member since Dec 2014
29594 posts
Posted on 8/12/15 at 8:15 pm to
I've made a killing off of fools like you and your quest for the elixir of life.
Posted by white perch
the bright, happy side of hell
Member since Apr 2012
7636 posts
Posted on 8/12/15 at 8:15 pm to
no, malaria can be treated with oral antibiotics. Proper mosquito prevention plans can help as well.

DDT (which kills mosquitos) was saving millions of lives before it was outlawed because of its effect on birds.

birds are more important than people you know

Posted by white perch
the bright, happy side of hell
Member since Apr 2012
7636 posts
Posted on 8/12/15 at 8:17 pm to
quote:

elixir of life




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