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Tirzepatide vs Reta

Posted on 1/29/26 at 10:06 pm
Posted by Big Scrub TX
Member since Dec 2013
39175 posts
Posted on 1/29/26 at 10:06 pm
Is there any literature yet that strongly points to Reta being superior to Tirzepatide?
Posted by lsu777
Lake Charles
Member since Jan 2004
37323 posts
Posted on 1/30/26 at 8:19 am to
Yea the three year study released strongly suggest Reta. Reta is much much better for fat loss and much better overall for health.
Posted by Jerrysworld
Lafayette
Member since Sep 2016
223 posts
Posted on 1/30/26 at 8:58 am to
where are we getting it from?
Posted by Boss
Member since Dec 2007
1772 posts
Posted on 1/30/26 at 9:30 am to
I'm about to start microdosing, and for now think I am going to stick with Tirz. I'm not too keen on the idea of having to reconstitute Reta. I don't need to lose a ton, but I've seen before/after pics of guys who are using it to cut and reduce BF%, and it's impressive. Plus Tirz you can get from any online pharmacy, and you don't need to go grey/black market.
Posted by lsu777
Lake Charles
Member since Jan 2004
37323 posts
Posted on 1/30/26 at 9:30 am to
Qsc, bba have it
Posted by SETH6180
TEXAS
Member since Feb 2020
1000 posts
Posted on 1/30/26 at 9:40 am to
All comes from the same place
Posted by Bleed P&G
New Orleans
Member since Aug 2003
3094 posts
Posted on 1/30/26 at 9:50 am to
I've taken both and have had success with both. I'll give you my 2 cents.

Both are effective. I find that Tirz is much better at appetite suppression and helps more with reduced cravings, which for me, made to easy to turn down sweets and alcohol. That's not to say that Reta doesn't suppress appetite, just that Tirz is better.

With Tirz, I had almost zero side effects. Some people get fatigued, but I never had that problem. Constipation was the only side effect.

With Reta, that isn't a problem, but I do have issues with sleep, which I am finding out is a common side effect. I believe it is because Reta increases your heartrate and metabolism, and that causes the sleep issues. Even with the sleep issues, I am still consistently getting 7+ hrs each night.

I took Tirz for about 15 months and lost 75 lb in the first 9 months. In the next three months, I had hit a wall and couldn't seem to get below 17 %BF. I then titrated down over three months, which was recommended by my doctor, to help prevent any rebounding of weight.

Flash forward a year, I am now taking Reta after doing a 6 month bulk. I started titrating up after Thanksgiving. I started taking it to help with the holidays. I started a 500 cal per day deficit in the begging of January. I have maintained muscle and am down 5 lb of fat, going from 19.7% down to 17.5% BF.
Posted by SETH6180
TEXAS
Member since Feb 2020
1000 posts
Posted on 1/30/26 at 9:58 am to
How many mg's of reta are you on weekly? I went from 13% BF to about 10% using .5-.75 mg per week. No muscle/strength loss at all.
This post was edited on 1/30/26 at 10:00 am
Posted by Boss
Member since Dec 2007
1772 posts
Posted on 1/30/26 at 9:59 am to
What was your dosing on Tirz and on Reta...starting and then end point. ALso did you do once or twice a week?
Posted by Bleed P&G
New Orleans
Member since Aug 2003
3094 posts
Posted on 1/30/26 at 10:22 am to
For Tirz, I started with 2.5 mg weekly. I did that for 4 weeks and then went up to 5 mg per week. I stayed at 5 mg for a few months, but not exactly sure for how long, maybe 5 months. I then went up to 7.5 mg weekly and stayed there.

For Reta, I started at 2 mg weekly for 3 weeks, then 4 mg weekly for 3 weeks. I am now at 6 mg weekly and am planning to stay here. I know there are a lot of people that microdose Reta, but the latest information from the Eli Lilly trials have people working up to 8mg weekly and staying there. Also, I have read that the glucagon effects start to hit at 4-6 mg.
Posted by Big Scrub TX
Member since Dec 2013
39175 posts
Posted on 1/30/26 at 10:23 am to
quote:

Yea the three year study released strongly suggest Reta. Reta is much much better for fat loss and much better overall for health.
Would you link it please?
Posted by Big Scrub TX
Member since Dec 2013
39175 posts
Posted on 1/30/26 at 10:23 am to
quote:

where are we getting it from?
I've been getting it from a place in China and then commissioning indeendent 3rd party tests of it in the US.
Posted by Big Scrub TX
Member since Dec 2013
39175 posts
Posted on 1/30/26 at 10:28 am to
quote:

Both are effective. I find that Tirz is much better at appetite suppression and helps more with reduced cravings, which for me, made to easy to turn down sweets and alcohol. That's not to say that Reta doesn't suppress appetite, just that Tirz is better.


Here's my situation. I am in total body reconstitution mode, with the primary focus on lean gains. I don't care if I lose/gain overall as long as my comp ends up right. 2025 was overall a success - particularly with lean, but the fat and visceral fat have been annoyingly persistent.

So, back in mid-Dec, I started at 500 reta and have now titrated up to 2. At times, I have some very mild appetite suppression, but in general, I am very diligent about still hitting my cals and macros (currently targeting 2200: 180ish protein, 220ish, carb, 70ish fat).

I've been basing the titrating up on how much I notice the appetite suppression. e.g. This entire week on 2, I feel almost normally hungry...so I plan to go up to 2.5 etc etc until i hit 4-6. Does this sound right?

Looking for any/all input on this plan. I want to have confidence that I can continue to gain lean, but have a lot of the fat melt away.
Posted by Bleed P&G
New Orleans
Member since Aug 2003
3094 posts
Posted on 1/30/26 at 10:41 am to
quote:

I am very diligent about still hitting my cals and macros (currently targeting 2200: 180ish protein, 220ish, carb, 70ish fat).

This is very close to my macro goals at the moment and I am easily able to hit them while on Reta.

quote:

This entire week on 2, I feel almost normally hungry...so I plan to go up to 2.5 etc etc until i hit 4-6. Does this sound right?

If it were me, I would skip the 500 mcg jumps and go strait to 3 mg and see how you feel. If you feel good then go to 4 after a couple of weeks and then to 6. When I jumped to 6mg is when I noticed the appetite suppression being similar to my experience with Tirz.
Posted by Uncle JackD
Member since Nov 2007
59484 posts
Posted on 1/30/26 at 11:10 am to
Reta has very impressive trial results but I’m in the minority and prefer tirz. Calms my cravings for sweets & alcohol way more than Reta did. Plus I wasn’t in love either the elevated resting HR from Reta.

I may try it again at super low dose in the future once I’m out of tirz.
Posted by Uncle JackD
Member since Nov 2007
59484 posts
Posted on 1/30/26 at 11:11 am to
quote:

where are we getting it from?



Posted by SETH6180
TEXAS
Member since Feb 2020
1000 posts
Posted on 1/30/26 at 11:12 am to
Just curious but why would you jump up so drastically? Does it not stand to logic that you should take the minimum effective dosage that shows results?
Posted by Big Scrub TX
Member since Dec 2013
39175 posts
Posted on 1/30/26 at 11:33 am to
quote:

his is very close to my macro goals at the moment and I am easily able to hit them while on Reta.
I don't completely understand the caloric deficit situation. Let's say this cal level is exactly replacement for me. I'm also doing 3 high intensity hypertrophic workout sessions/week + a HIIT and a sprint series per week. Given this program, should I expect continued lean gains while also melting fat? Or do I need to just eat less anyway?

How quickly will I start seeing noticeable fat melt? I'm about 6 weeks in now and not sure I've seen any.
Posted by Bleed P&G
New Orleans
Member since Aug 2003
3094 posts
Posted on 1/30/26 at 11:35 am to
If you are having success at a low does, keep at it. However, there is a lot of information out there that suggests that the targeted maintenance dosage is around 8mg.
Posted by lsu777
Lake Charles
Member since Jan 2004
37323 posts
Posted on 1/30/26 at 1:08 pm to
Phase 2

Phase 3

Only issue, and it was mentioned, is Reta raises resting heart rate, tirz can be better for appetite suppressant effects but this causes many to undereat too much


So here is the deal on calories, use the muscle hacking leangains macro calculator as a starting point, setting it for 500 deficit, 0 steps per day and as normal muscle mass. That is your macros, do do maintenance then think that will get you there, don’t do that


So do the above, lift heavy 2-4 times per week

Stat your steps at 8k per day.

Weigh each day and take 2 week rolling average, if you are not going down after two weeks, bump the steps to 10k…then 12, then 14, then 16…keep until you hit 20k.

Trust me this works. Don’t lower calories. After you stalled on 20k steps, lower calories from fat and carbs by ~500 and then start back at 8k steps and keep going. Most never have to reset though. Some even go to 25k steps and even up to 30k but that is huge time commitment

That’s how you hold on to muscle mass while stripping fat systematically

For Reta, minimum effective dose. Pairs great with try, low dose gh, and glow
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