re: Supplements- that work Health and Performance

quote:

---

Also, assuming the amounts of EPA and DHA are the same, what is the advantage of Krill oil over fish oil?

---

they are similar but the biggest thing is risk of oxidation vs fish oil. I suggest both a krill oil supp and a quality fish oil with vitamin D.

below are a bunch of studies that show krill oil is more effective...BUT...that is only because its more effecient dose for dose. when normalized

quote:

---

The lipid-modifying effects of krill oil and fish oil do not differ. The reduction in triglycerides depends on the dose of n-3 fatty acids consumed.

---

LINK

also

quote:

---

Two human studies – one postprandial study and one intervention study – used the same amount of EPA and DHA from KO or FO, and they both showed that the bioavailability of EPA and DHA from KO seems to be higher than that from FO. Limited effects of KO and FO on lipids and inflammatory markers in human and animal studies were reported. Gene expression data from animal studies showed that FO upregulated the cholesterol synthesis pathway, which was the opposite of the effect mediated by KO. KO also regulated far more metabolic pathways than FO, which may indicate different biological effects of KO and FO.

---

LINK

quote:

---

Although krill oil had a more beneficial effect on blood glucose than fish, fish is also a good source of other health-beneficial nutrients, including vitamin D.

---

LINK

quote:

---

The primary finding of the present study was that plasma concentrations of EPA, DPA, and DHA increased significantly in both the krill oil and fish oil groups compared with the control group following daily supplementation for 7 weeks. There was no statistically significant difference between these two groups in the levels of the increases in EPA and DHA. Since the subjects in the krill oil group received 62.8% of the total amount of n-3 PUFAs received by the subjects in the fish oil group, these findings indicate that the bioavailability of n-3 PUFAs from krill oil (mainly PL) is as, or possibly more, efficient as n-3 PUFA from fish oil (TG). This supports the results of a previous study with krill oil and menhaden oil in humans

---

LINK

quote:

---

By using gene expression profiling in the small intestine, we provide evidence that Omega-3 supplemented as PLs from krill oil are more effective than Omega-3 administered at the same dose as re-esterified TAG in terms of effects on intestinal gene expression, while also enhancing mitochondrial ß-oxidation of FAs. Despite the fact that both forms of Omega-3 supplementation affected pathways involved in ?-oxidation, krill oil supplementation had more pronounced effects on gene expression and its effect was much broader in terms of the number of pathways affected. This effect of krill oil was linked to improved bioavailability of Omega-3, primarily EPA, and may be responsible for superior metabolic effects of marine PLs, especially when the reduction of hepatic steatosis and improved glucose tolerance are concerned. Thus, our results point to the small intestine and gut-mesenteric WAT-liver interaction as one of the major targets of krill oil administration.

---

LINK

quote:

---

The changes in the hepatic sphingolipids and 20:4 fatty acid levels were greater in the KO compared to the FO fed mice, and are consistent with a hypothesis that krill oil will have a stronger anti-inflammatory action and enhances insulin sensitivity more potently than fish oil.

---

LINK