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re: The FDA has issued an Emergency Use Authorization (EUA) for Eli Lilly’s bebtelovimab

Posted on 2/22/22 at 8:39 am to
Posted by tigger42day
Just south of Mizery
Member since Oct 2004
7126 posts
Posted on 2/22/22 at 8:39 am to
The “don’t give if admitted” policy is a flawed logic by Doctors and the hospitals. It applies to people who’ve had clinical signs for an extended period but not for newly infected patients.

The MAB’s are only effective early in the course of infection. As with any virus, Covid only replicates in the body for a set time period. During that time, the introduction of MAB’s (if properly matched to the virus variant), slow to stop virus replication and hence prevent further virus damage. They are highly effective early on in the infection. My wife (no pictures) and I had BamlanviMaB in late 2020 and it dead stopped any clinical signs.

Most people who enter the hospital are not there due to the virus alone, they are there due to comorbidities getting out of hand and/or secondary effects following the viral infection (bacterial pneumonia, systemic reactions, organ failure Etc,). These people are beyond the virus replication phase of the infection. Introduction of MAB’s at this point is usually useless and can creat the issues described worsening the situation due to immune system “stimulation”

In the patient you described, if properly matched, the MAB should have worked very well.
Posted by tigger42day
Just south of Mizery
Member since Oct 2004
7126 posts
Posted on 2/22/22 at 8:45 am to
Monoclonal Antibodies (MAB’s) are very specific for a virus variant.

A monoclonal for the original Alpha variant (BamlanviMaB) is completely ineffective against the new Omicron strain.

Since there is no significant Alpha left circulating, it’s removal from the market is very appropriate.

I do believe they pulled the MAB’s for Delta too soon. At that point 90% of cases were Omicron but that still left close to 10% Delta and it was likely the variant sending people with co-morbidities to the hospital.
Posted by Jjdoc
Cali
Member since Mar 2016
53613 posts
Posted on 2/22/22 at 8:48 am to
Ivermectin!
Posted by LAhinguarst
The Box
Member since Oct 2020
401 posts
Posted on 2/22/22 at 8:54 am to
quote:

Why would anyone take something they can’t pronounce for mild to moderate symptoms??? How about some Tylenol or Advil and a cough drop?



One is treating the symptoms of the virus. The other is actively fighting the virus with your immune system. Short term it may make you feel worse, which you can treat with the OTC meds you mentioned. The theory here is that you won't suffer from the virus as long bc your body has the antibodies needed to get rid of it.

Id take being sick for 3 days over being sick for weeks.

Posted by narddogg81
Vancouver
Member since Jan 2012
19750 posts
Posted on 2/22/22 at 9:25 am to
quote:

If you are only mildly sick, you will feel like it is getting worse after the MAB infusion for about 12 hours. Ask around, many/most people report feeling much worse after the MAB. Eventually you get better as your body gets the virus under control. If you are very sick, receiving MAB could make this “getting worse” phase so bad that you need advanced care like icu or intubation.
I had moderate Delta, got antibodies on day 9. I wouldn't say it made my general symptoms worse, but it did spike my fever up to 105 for like an hour. I felt better considerably the next day
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