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peer-reviewed coronavirus vaccine shows promise in mice
Posted on 4/2/20 at 2:09 pm
Posted on 4/2/20 at 2:09 pm
A new potential vaccine against the coronavirus sweeping the world has showed promise in mice, researchers at the University of Pittsburgh School of Medicine said Thursday.
In a peer-reviewed study published in the medical journal EBioMedicine, the researchers said their new development comes from earlier vaccines they had created to fight the two other deadly coronavirus strains already known: SARS, which broke out in China in 2003, and MERS, which hit Middle Eastern countries and South Korea in 2014.
"We have been designing coronavirus vaccines since 2003," Andrea Gambotto, an associate professor of surgery at the Pitt School of Medicine and one of the study's two lead authors, told The Hill in an interview.
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The researchers repurposed those earlier vaccines to target a specific protein that protrudes from the new version.
"For us, it was easy to switch gears from one target to the other," Gambotto said. "We had all the pieces together."
The study showed that when tested in mice, the vaccine produced antibodies that were specific to the current coronavirus, and in quantities that are likely sufficient to neutralize the virus.
Unlike many vaccines, the Pitt-developed version would be delivered by a fingertip-sized patch that scratches the surface of a recipient's skin. The scientists said the immune system reacts more strongly to irritations on the skin, in hopes of triggering it to recognize the coronavirus more quickly.
The delivery method is similar to a vaccine used to eradicate smallpox, said Louis Falo, chair of the dermatology department at the Pitt School of Medicine and the University of Pittsburgh Medical Center. Falo said the team hoped to begin tests on human volunteers in short order. LINK
In a peer-reviewed study published in the medical journal EBioMedicine, the researchers said their new development comes from earlier vaccines they had created to fight the two other deadly coronavirus strains already known: SARS, which broke out in China in 2003, and MERS, which hit Middle Eastern countries and South Korea in 2014.
"We have been designing coronavirus vaccines since 2003," Andrea Gambotto, an associate professor of surgery at the Pitt School of Medicine and one of the study's two lead authors, told The Hill in an interview.
ADVERTISEMENT
The researchers repurposed those earlier vaccines to target a specific protein that protrudes from the new version.
"For us, it was easy to switch gears from one target to the other," Gambotto said. "We had all the pieces together."
The study showed that when tested in mice, the vaccine produced antibodies that were specific to the current coronavirus, and in quantities that are likely sufficient to neutralize the virus.
Unlike many vaccines, the Pitt-developed version would be delivered by a fingertip-sized patch that scratches the surface of a recipient's skin. The scientists said the immune system reacts more strongly to irritations on the skin, in hopes of triggering it to recognize the coronavirus more quickly.
The delivery method is similar to a vaccine used to eradicate smallpox, said Louis Falo, chair of the dermatology department at the Pitt School of Medicine and the University of Pittsburgh Medical Center. Falo said the team hoped to begin tests on human volunteers in short order. LINK
Posted on 4/2/20 at 2:11 pm to Jbird
What’s their NYSE ticker name?
Posted on 4/2/20 at 2:46 pm to Jbird
Associate Professor of Surgery and Head of Dermatology Dept., are lead researchers? That’s odd.
Posted on 4/2/20 at 2:51 pm to Diamondawg
quote:I didn't see that in the link.
Associate Professor of Surgery and Head of Dermatology Dept., are lead researchers?
Posted on 4/2/20 at 2:54 pm to TigerFanInSouthland
quote:
What’s their NYSE ticker name?
You know how we know you aren't a congressman?
Posted on 4/2/20 at 2:56 pm to TigerFanInSouthland
quote:
What’s their NYSE ticker name?
I bet Dianne Feinstein and that bitch from GA could tell you.
Posted on 4/2/20 at 3:05 pm to Jbird
Peer reviewed means absolutely nothing.
Posted on 4/2/20 at 3:06 pm to SevenLinesofPine
quote:Ok.
Peer reviewed means absolutely nothing.
Posted on 4/2/20 at 3:08 pm to Jbird
Thank goodness. I was worried about the mice getting sick.
But seriously, this can only be positive.
But seriously, this can only be positive.
Posted on 4/2/20 at 3:55 pm to Diamondawg
quote:
Associate Professor of Surgery and Head of Dermatology Dept., are lead researchers? That’s odd.
The dermatology doesn't seem too far fetched.
From the journal article:
quote:
Notably, MNA delivery of these vaccines generated significantly stronger immune responses than those administered by traditional subcutaneous needle injection, indicating the improved immunogenicity by skin-targeted delivery.
Looks like some interesting shite
Posted on 4/2/20 at 3:55 pm to TBoy
quote:
TBoy
Tha fuq is your side doing to help?
Posted on 4/2/20 at 4:44 pm to SevenLinesofPine
Depends on the peers.
Posted on 4/2/20 at 4:45 pm to SouthernHog
quote:
Tha fuq is your side doing to help?
"It's a wonder that you still know how to breathe."
Posted on 4/2/20 at 4:46 pm to SouthernHog
Just tell tranny boy to piss up a rope.
Posted on 4/2/20 at 4:47 pm to Jbird
Why are we treating mice before people?? We needs some priories in this country.
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