re: Homosexuality not caused by genetics. They ar not "born that way ETA Addit link added

quote:

---

Nobody has a clue on this

---

quote:

---

Half of these aren't even environmental exposures.

---

quote:

---

Now your claiming that I'm implying something I never implied.

---

quote:

---

I've seen your posts on this topic and I understand how irrationally you usually post about it

---

quote:

---

it's not unreasonable to believe homosexuality has at least some genetic component as well. Not provable at this time, but reasonable.

---

quote:

---

updated link

---

quote:

---

disproves

---

quote:

---

But it is fair to say we don't yet have it nailed down either.

---

quote:

---

Jesus, thanks for a journal that has only the ansract to read!

---

quote:

---

Discussion
We have detected genome-wide significant linkage to pericentromeric chromosome 8 with multipoint support, and replicated linkage to chromosome Xq28. In context with the previous linkage scans, it seems likely that genes contributing to variation in male sexual orientation reside in these regions. As usual with linkage peaks for complex traits, there are a number of genes of potential relevance under each broad peak, such as transcription factors, microRNAs, and various brain-expressed genes including some with neurodevelopment, neuroendocrine, and/or neurotransmission roles (e.g. CHRNB3, CHRNA6, SNTG1, NPBWR1, OPRK1, RGS20, PENK, CRH, TRPA1, GDAP1, SLITRK2, CNGA2, GABRE, GABRA3, GABRQ, PLXNB3, L1CAM, GDI1, PLXNA3), and at Xq27–28 the testes-specific members of the SPANX (sperm protein associated with the nucleus on chromosome X) family (these ones being ampliconic genes independently acquired since human-mouse divergence; Mueller et al. 2013). We comment further on selected examples, acknowledging the speculative nature of genotypebehavior correlations across species (e.g. human and mice) and even between more closely related species (e.g. within rodents) (Baud et al. 2013). Arginine vasopressin is a hormone that mediates social and affiliative behaviors (see review by Ebstein et al. 2012), and one of its receptors (AVPR2, arginine vasopressin receptor 2) is located on Xq28, although AVPR2 is primarily expressed in the kidney. However, neuropeptides B/W receptor 1 (NPBWR1) on 8q11.23 is expressed in limbic regions including the hippocampus, has been shown to modulate social interactions in mice (Nagata-Kuroiwa et al. 2011), and a common functional variant (Tyr135Phe, rs33977775, CEU MAF~10%) has been reported as associated with altered emotional responses to facial expressions in humans, especially valence (with heterozygotes perceiving expressions in more pleasant terms) (Watanabe et al. 2012). Another brain-expressed gene, CNGA2 (cyclic nucleotide gated channel alpha 2) on Xq28, has been shown in mice to be critical for regulation of odor-evoked socio-sexual behaviors, including major histocompatibility complex (MHC)-related odors (Mandiyan et al. 2005; Spehr et al. 2006); and although more uncertain, MHC-related odors may have relevance in social communication and mate selection in humans (Wedekind et al. 1995; Havlicek & Roberts, 2009; Milinski et al. 2013). However, linkage can only indicate a region and not particular genes, a task better suited to other approaches such as resequencing approaches, GWAS, and meta-analyses thereof. Our findings may also begin to provide a genetic basis for the considerable evolutionary paradox that homosexual men are less motivated than heterosexual men to have procreative sex and yet exist as a stable non-trivial minority of the population (Wilson, 1975; Bell & Weinberg, 1978).

LINK

---

quote:

---

ansract

---