MRNA vaccines and covid

From Wikipedia

For Moderna

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On 14 July 2020, Moderna scientists published preliminary results of the Phase I dose escalation clinical trial of mRNA-1273, showing dose-dependent induction of neutralizing antibodies against S1/S2 as early as 15 days post-injection. Mild to moderate adverse reactions, such as fever, fatigue, headache, muscle ache, and pain at the injection site were observed in all dose groups, but were common with increased dosage.[75] The vaccine in low doses was deemed safe and effective in order to advance a Phase III clinical trial using two 100-µg doses administered 29 days apart.[75]

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For Pfizer

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Phase I–II Trials were started in Germany on 23 April 2020, and in the U.S. on 4 May 2020, with four vaccine candidates entering clinical testing.[25][31] The vaccine candidate BNT162b2 was chosen as the most promising among three others with similar technology developed by BioNTech.[85] Before choosing BNT162b2, BioNTech and Pfizer had conducted Phase I trials on BNT162b1 in Germany and the United States, while Fosun performed a Phase I trial in China. In these Phase I studies, BNT162b2 was shown to have a better safety profile than the other three BioNTech candidates.[144][24][145][146] The Pivotal Phase II–III Trial with the lead vaccine candidate "BNT162b2" began in July. Preliminary results from Phase I–II clinical trials on BNT162b2, published in October 2020, indicated potential for its safety and efficacy.[24] During the same month, the European Medicines Agency (EMA) began a periodic review of BNT162b2.[147]

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So, to answer your question, there was a Phase II. Under the conditions of Operation Warp Speed, they were allowed to overlap both Phases to save time.

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hanks for the serious response. Have any other viruses been fought with this same type of technology (mRNA)? Honest question, because I don’t believe they have. So why not?

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I’m not sure off the top of my head if there is an mRNA vaccine that predates COVID, but I do know it is cutting edge technology, and there’s always a first in anything.

I do know that the success of the COVID mRNA vaccine has spurred intense research into mRNA tech for a possible HIV vaccine.

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Money.

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Occam’s razor wins again

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So there was a little bit more pressure to get a vaccine out and to cut through the red tape for COVID as opposed to AIDS.

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That makes sense, for sure. This virus is the worst we’ve had since Spanish flu and the plague. Amazing that we developed a vaccine so quickly and used medical advances to combat it. But damn why haven’t we made a flu vaccine using this technology, it has killed about 1/5 the numbers of COVID yearly. Maybe this vaccine creation and approval will end up saving lives in the long run.

This may be a good thread to ask something that’s been bugging me

This is all just my understanding so if I have misunderstood the basic facts of the three vaccines please by all means correct me

My understanding is that the phizer and Moderna vaccines both use the “new” mRNA style of vaccination

Meanwhile the Johnson and Johnson vaccine uses the “traditional” protein style like the flu shot where the vaccine creates a fake virus similar to the real virus that essentially teaches the body how to fight off the real virus

My question is if the “old” or “traditional” style of vaccine works why did they go through so much trouble to produce vaccines that do things the “new” or mRNA method?

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My question is if the “old” or “traditional” style of vaccine works why did they go through so much trouble to produce vaccines that do things the “new” or mRNA method?

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I’m wondering the same thing, and my guess has been the efficacy of the mRNA method. I could be wrong though I’m far from a scientist

So efficacious that you need a 3rd, 4th, and beyond booster.

I am disappointed with Mrna overall. It seemed like a revolutionary technology but the prospect of endless shots has me unimpressed.

Sir, this is a Wendy's.

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* accepts quoted answer from Wikipedia, a site that literally anyone with an internet connection and the ability to type can edit.

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Do you see the numbers within the brackets? Usually follows the end of a sentence... That's a reference. Meaning there are endnotes and the previous words have a source. So the information has been verified

Sure you can go and edit Wikipedia, but usually, the changes are reviewed quickly for more common pages. Teachers hated on Wikipedia because they wanted us to do more than one stop shop research

Would.