re: What’s the best way to Knoxville from Houston or New Orleans?

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Flights into Knoxville are going for $750 so wanted to provide an alternative.

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Asheville is two hours away. Get a hotel in Kodak, just outside Knoxpatch.

It's not a bad drive at all. Airport is adjacent to I-26. All interstate from that point pretty much.

You certainly won't spend $250 bucks on gas. Hotel should be cheaper in Kodak as well.