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RAD-140 and MK-677
Posted on 4/9/25 at 6:50 pm
Posted on 4/9/25 at 6:50 pm
A friend who knows his stuff just told me about this. Have these been brought up here? Thoughts?
Posted on 4/9/25 at 7:54 pm to pwejr88
I have no first hand experience, but from what I’ve read the SARMS seem like they’re less effective than anabolic steroids and still carry similar health risks. I think if I was going one of the two routes I’d go with the steroids.
Posted on 4/9/25 at 9:20 pm to HVAU
I was told to take for a month and then cycle off for 3-4 weeks.
Posted on 4/9/25 at 9:36 pm to pwejr88
I’d look into whether or not you need to take enclo during that cycle. Like I said I have no firsthand experience, but I’ve read there some natural hormone production suppression.
I can’t remember, but I think one of the two (Rad-140 and Mk-677) was a bit more aggressive than the other.
There’s whole sarms subreddit that would give you much better guidance than I can.
I can’t remember, but I think one of the two (Rad-140 and Mk-677) was a bit more aggressive than the other.
There’s whole sarms subreddit that would give you much better guidance than I can.
Posted on 4/10/25 at 7:12 am to pwejr88
I know who people who have used them and had decent results. Personally, I’d use CJC/Ipamoreline or Tesamorelin/Ipamorelin for better results.
I’m 6 weeks into tesa/IPA and navel measurements are down 1.5”
I’m 6 weeks into tesa/IPA and navel measurements are down 1.5”
Posted on 4/10/25 at 7:32 am to pwejr88
mk-677 is not a sarm. it is a ghrelin agonist. It is a growth hormone secretagogues receptor (think growth hormone releasing peptide except mk677 is not a peptide and binds at the ghrelin receptor inducing a release of GH, mimicking a ghrp.)
a 25mg dose is similar to roughly 2iu of growth or essentially putting you in the very high end of an 18 year old male.
issue is mk677 makes you extremely sleepy, causes water retention and negatively effects blood sugar.
good things are it makes you hungry AF because of the ghrelin. Im talking never ending hunger that hurts.
it has no real negative feedback loop that causes suppression so extremely easy to recover from. it has zero effect on the sex hormones either.
overall a very very safe compound that should be used for bulking with the understanding that almost all of your gains will be through increased hunger. Should be taken at night so the sleepiness is put to good use.
i usually have teens that need to gain weight start on the ppsa eating thick plan. after they plateau i have them start 5g creatine, after another plateau if they are want something more and are talking about turning to SARMS or juice, i tend to steer them to double the creatine and add in 20mg of mk677 to drive weight up
its not really what i prefer but much prefer someone take something non hormonal like mk677 than something like a rad-140 which is, at least when it comes to teens. Just trying to protect the endocrine system as much as possible.
works very well but watch BP, water retention and blood sugar. Usually take for 12-16 weeks because you are looking to add mass from the extra food but if BP & blood sugar are under control, can be run for 6+ months. Usually start at 20mg and raise as needed to keep hunger there.
as far as rad-140. it is a SARM. it will shut down natural test production and although it is not methylated at the c-17 position, it does have a slight effect on liver values.
it is a pretty versatile sarm. It will add lots of strength and can be used to cut or bulk. it will harden you and add some muscle too if diet is on point.
things to watch on it BP, no drinking on it, etc. this will cause suppression of HPTA just like a steroid cycle so you will need to add a post cycle therapy if not on TRT. Also because it suppresses natural test, could cause lack of sex drive, loss of energy etc if not on TRT.
usually run for 8-12 weeks. starting at 15-20mg and titrate up as handled
science bio is the place to get those types of things.
hope this helps, fire any questions you may have. IMO if you are not
1) making money off your body or
2) not on trt
then i wouldnt do anything like Rad-140 just due to suppression. FTR taking these things does make you not a lifetime natty.....not that anyone cares as TRT does too.
a 25mg dose is similar to roughly 2iu of growth or essentially putting you in the very high end of an 18 year old male.
issue is mk677 makes you extremely sleepy, causes water retention and negatively effects blood sugar.
good things are it makes you hungry AF because of the ghrelin. Im talking never ending hunger that hurts.
it has no real negative feedback loop that causes suppression so extremely easy to recover from. it has zero effect on the sex hormones either.
overall a very very safe compound that should be used for bulking with the understanding that almost all of your gains will be through increased hunger. Should be taken at night so the sleepiness is put to good use.
i usually have teens that need to gain weight start on the ppsa eating thick plan. after they plateau i have them start 5g creatine, after another plateau if they are want something more and are talking about turning to SARMS or juice, i tend to steer them to double the creatine and add in 20mg of mk677 to drive weight up
its not really what i prefer but much prefer someone take something non hormonal like mk677 than something like a rad-140 which is, at least when it comes to teens. Just trying to protect the endocrine system as much as possible.
works very well but watch BP, water retention and blood sugar. Usually take for 12-16 weeks because you are looking to add mass from the extra food but if BP & blood sugar are under control, can be run for 6+ months. Usually start at 20mg and raise as needed to keep hunger there.
as far as rad-140. it is a SARM. it will shut down natural test production and although it is not methylated at the c-17 position, it does have a slight effect on liver values.
it is a pretty versatile sarm. It will add lots of strength and can be used to cut or bulk. it will harden you and add some muscle too if diet is on point.
things to watch on it BP, no drinking on it, etc. this will cause suppression of HPTA just like a steroid cycle so you will need to add a post cycle therapy if not on TRT. Also because it suppresses natural test, could cause lack of sex drive, loss of energy etc if not on TRT.
usually run for 8-12 weeks. starting at 15-20mg and titrate up as handled
science bio is the place to get those types of things.
hope this helps, fire any questions you may have. IMO if you are not
1) making money off your body or
2) not on trt
then i wouldnt do anything like Rad-140 just due to suppression. FTR taking these things does make you not a lifetime natty.....not that anyone cares as TRT does too.
This post was edited on 4/10/25 at 7:39 am
Posted on 4/10/25 at 7:39 am to lsu777
quote:
a 25mg dose is similar to roughly 2iu of growth
So how much taller will that make me or am I screwed?
Posted on 4/10/25 at 7:41 am to Loup
quote:
So how much taller will that make me or am I screwed?
if growth plates are closed....screwed
if not, gh therpy has been shown to increase ~3" on average.
Posted on 4/10/25 at 7:56 am to Uncle JackD
quote:
I’m 6 weeks into tesa/IPA
Not to hijack this thread, but I have been curious about this protocol. What are your doses and source, if you don't mind sharing.
Posted on 4/10/25 at 8:01 am to The Dudes Rug
quote:These came from QSC prior to them closing shop. I’m doing tesa 2mg IPA 250mcg Before bedtime. I will be checking an IGF level next week to see how things look.
Not to hijack this thread, but I have been curious about this protocol. What are your doses and source, if you don't mind sharing.
Posted on 4/10/25 at 8:02 am to The Dudes Rug
dosing on the ghrh/ghrp protocols depends on how you want to do it
imo if using the cjc as ghrp...tesa and ipam as ghrp it would look something like this
morning-250mcg of tesa/cjc
get some kind of walk in while fasted. no eating for 2 hours after injection. more movement you can get the better here
eat protein based breakfast...limit fat intake though
mid morning- repeat morning and protocol
then at night before bed....boom dose. so 250mcg cjc and 1500-2500mcg of ipam.
this is the best protocol imo
but start another thread and we can discuss. just call it GH peptide protocols.
imo if using the cjc as ghrp...tesa and ipam as ghrp it would look something like this
morning-250mcg of tesa/cjc
get some kind of walk in while fasted. no eating for 2 hours after injection. more movement you can get the better here
eat protein based breakfast...limit fat intake though
mid morning- repeat morning and protocol
then at night before bed....boom dose. so 250mcg cjc and 1500-2500mcg of ipam.
this is the best protocol imo
but start another thread and we can discuss. just call it GH peptide protocols.
Posted on 4/10/25 at 9:03 am to Uncle JackD
I’m considering but tesa/ipamorelin blend
Are you taking it morning and evening?
Are you taking it morning and evening?
Posted on 4/10/25 at 9:08 am to lsucoonass
quote:Evenings. It may be coincidence but my sleep has been incredible lately.
considering but tesa/ipamorelin blend Are you taking it morning and evening?
Posted on 4/10/25 at 9:23 am to Uncle JackD
quote:
Evenings. It may be coincidence but my sleep has been incredible lately.
its not, you should always take a dose before bed, preferably boom dose to match natural GH release
but also taking a smaller dose in the morning and every 3-4 hours if possible for fat burning. if using it to put on muscle its the same but use ghrp2 to induce more hunger
Hex is still the strongest ghrp but has the big down regulation so only 6 week or so cycles before having to more to ipam as the ghrp.
tesa is great for visceral fat, better than the other ghrps.
still need to take a ghrh with these for max benefits.
Posted on 4/10/25 at 9:26 am to lsu777
quote:Of Tesa or IPA ?
but also taking a smaller dose in the morning and every 3-4 hours if possible for fat burning
quote:Yeah that’s the main reason I swapped from CJC to Tesa. If my measurements are accurate, it definitely helped over the past 6 weeks.
tesa is great for visceral fat, better than the other ghrps.
Posted on 4/10/25 at 9:31 am to lsu777
I was told on RAD-140 if I do four weeks on and then four weeks off, my test production and hormones would be fine and back to normal.
That accurate?
Also, does it cause hair loss?
That accurate?
Also, does it cause hair loss?
This post was edited on 4/10/25 at 9:31 am
Posted on 4/10/25 at 9:36 am to pwejr88
quote:
I was told on RAD-140 if I do four weeks on and then four weeks off, my test production and hormones would be fine and back to normal.
That accurate?
no, well i mean maybe. but usually you want to do longer cycles of that as its not like its a methylated oral that is gonna stack tons of mass. you would be lucky to hold on to 3-4 pounds over the 12 weeks of doing the 4 on, 4 off.
as far as HPTA bouncing back...depends on a lot of things but rad is suppressive just like steroids and is one of the stronger sarms with LGD being the strongest along with YK11(technically steroidal in nature based off the molecular shape)
as far as hair loss...yea it can cause hair loss if predisposed to it.
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