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Metformin in non diabetic
Posted on 2/21/22 at 4:50 pm
Posted on 2/21/22 at 4:50 pm
I recently had a colonoscopy in which 2 pre cancerous polyps were removed. Doing some research I saw that metformin may help in treatment and prevention of colon polyps. There is also a lot of other info available including possibly anti aging properties.
Do any of you have experience with this?
Do any of you have experience with this?
4
Posted on 2/21/22 at 5:37 pm to tom1987
Lots of good evidence for the anti-aging benefits, but there are side effects such as decrease in energy and stamina.
I take NMN for similar anti-aging benefits.
I take NMN for similar anti-aging benefits.
Posted on 2/21/22 at 7:43 pm to tom1987
Metformin in just about every diabetic I ever talk to, ones starting out on it, all say that the diarrhea for a few weeks is awful.
It goes away but people either push through ( no pun intended ) or have to discontinue it . The first group is the overwhelming majority .
It goes away but people either push through ( no pun intended ) or have to discontinue it . The first group is the overwhelming majority .
Posted on 2/22/22 at 10:32 am to Lawyered
I went 3 days and said "hell no." Then a few weeks later tried again and pushed through. But there was no pushing involved. Lasted about 5 days.
Posted on 2/22/22 at 11:09 am to transcend
quote:
Lots of good evidence for the anti-aging benefits
There's a TAME trial still underway to determine that.
Posted on 2/25/22 at 5:17 am to CamdenTiger
As others have said, the diarrhea is pretty unrelenting in the beginning. A friend of ours was on it a few years ago. Wasn’t for diabetes though, I forgot why she was taking it. They were doing fertility treatment for a while and maybe it was part of that. Could be completely wrong about that but I do remember her telling me she was taking it for a while.
Posted on 2/25/22 at 9:49 am to jdaute2
quote:
I forgot why she was taking it. They were doing fertility treatment for a while and maybe it was part of that. Could be completely wrong about that but I do remember her telling me she was taking it for a while.
Metformin is frequently given to women with PCOS (poly cystic ovarian syndrome). Which is a very common cause of infertility.
I know cause I have PCOS and it’s why I couldn’t have kids. Metformin can help with PCOS symptoms and help a woman have more regular ovulation that could help her conceive.
I’ve been on Metformin a few years now for PCOS. Can still help with other PCOS symptoms not related to trying to get pregnant. The first few weeks it made me really really nauseous. Now I have no issues with it.
This post was edited on 2/25/22 at 9:51 am
Posted on 2/25/22 at 9:01 pm to tom1987
Every medication has a trade off. Do some research before you make a decision.
You might solve one problem but cause another.
You might solve one problem but cause another.
Posted on 2/26/22 at 8:11 am to lsunurse
Lsunurse, not quite sure why you got all the downvotes, appreciate the info.
Posted on 2/26/22 at 4:56 pm to jdaute2
I don't think it is gonna do you a whole lot of good if you are not insulin resistant (and yes, this may even be related to the protective mechanism against some cancers - that is a gigantic rabbit hole for sure, and very interestingly hearkens back to early to mid 20th century metabolic cancer origin theory (ie the work of Otto Warburg), which has been largely relegated to history in favor of genetic origin theories (and I use that term generically, not in the sense of strict heritability, but rather genetic mutations). There are plenty of folks out there that are not diabetic and not overweight, are not sedentary and still have some degree of insulin resistance or are perhaps on the edges of metabolic syndrome without frankly meeting the criteria. These are very likely the non-diabetic people that would see the most benefit from "recreational" (that's tongue-in-cheek) metformin use.
The reason metformin has a place in PCOS is breaking the insulin resistance chain part of the vicious cycle type of metabolic malfunction (it is a very wide-spectrum type of disorder). Sometimes it is enough to get women over the hump ovulating either alone or in combination with either clomiphene citrate or Letrazole. To clarify sometimes we use it pre-treatment for a few months, and sometimes in concert with the aforementioned drugs.
There is interest in metformin as a "longevity" drug for sure, and a good place to start gathering some decent information on the subject is to google "metformin and Peter Attia".
That's my two cents and I'll add one more thing - often times the extended release version given in split doses can help get around the often nasty GI side effects mentioned above.
The reason metformin has a place in PCOS is breaking the insulin resistance chain part of the vicious cycle type of metabolic malfunction (it is a very wide-spectrum type of disorder). Sometimes it is enough to get women over the hump ovulating either alone or in combination with either clomiphene citrate or Letrazole. To clarify sometimes we use it pre-treatment for a few months, and sometimes in concert with the aforementioned drugs.
There is interest in metformin as a "longevity" drug for sure, and a good place to start gathering some decent information on the subject is to google "metformin and Peter Attia".
That's my two cents and I'll add one more thing - often times the extended release version given in split doses can help get around the often nasty GI side effects mentioned above.
Posted on 2/28/22 at 5:43 pm to BigPapiDoesItAgain
quote:
There is interest in metformin as a "longevity" drug for sure, and a good place to start gathering some decent information on the subject is to google "metformin and Peter Attia".
I almost started this exact thread because I heard Attia talk about it. I’m super interested in his and Rhonda Patrick’s thoughts on healthspan. He’s super smart, but it’s hard to keep up with all his podcasts (the Drive). Anyway, for “reasons,” I think I may be insulin resistant to a certain extent, so I’ve really been interested in Metformin. For some reason, my mom (who was diagnosed with Type 2 diabetes a couple of years ago) has an stash of extra Metformin. I mentioned it to her a couple of weeks ago as a potential anti-aging drug, and anyway, she had enough extra to give me 2 months worth. I’m starting it Ash Wednesday and if no side effects and gonna try to take it until Easter and see the difference in my body comp and labs.
Posted on 3/1/22 at 10:39 pm to Hot Carl
quote:
He’s super smart, but it’s hard to keep up with all his podcasts (the Drive).
One has to pay careful attention for sure. I'm an MD, and enjoy reading and keeping up not only in my specialty, and oftentimes, I find myself going back and listening again as it can be so technical (but that's why I like it).
quote:
I’m starting it Ash Wednesday and if no side effects and gonna try to take it until Easter and see the difference in my body comp and labs.
I'd like to hear what your experience is from an exercise tolerance standpoint (if that's your bag) as the drug apparently can significantly lower mitochondrial performance and thus the lactate threshold to a significant degree.
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