re: Patients taking Eli Lilly's retatrutide lost 58 pounds, on average, in a phase 2 clinical

quote:

---

I am in clinical research and have worked on studies on GLP-1 agonists. I have never seen any data that even remotely supports that claim.

---

because it there isnt any on any wide spread list of patients

there were a couple that came out but they were isolated

and all that scare shite is coming from people who do not understand how the medicines work like you and I



so gonna make this very very fricking clear

1) GLP-1 agonists do not increase metabolic rate, do not decrease mtor, does not have any mechanism to cause uncoupling and does not cause the body to produce any excess heat

2) GLP-1 agonists work by controlling glucose secreation, slowing gastric emptying, suppressing glucagon....which when combined control the feelings of hunger and lowers blood sugar levels.

3) GLP-1 is a naturally occurring hormone in the small intestine


so in short this medicine does not burn fat nor does it burn muscle. simply put your ratio of fat to muscle loss will be determined by the following

1) total caloric deficit
2) length of time in the deficit
3) total protein intake
4) what type of lifestyle you live....i.e. are you weight training or are you training for a marathon. your body will respond accordingly to the demands you place on it.



SO STOP SAYING THE MEDICINE MAKES YOU LOSE MUSCLE!!!!

the medicine has not effect on that. Simply put the dexa scans that showed that were from women in extreme deficits eating less than 1k calories on avg and less than 50g protein all while not doing any form of resistance training. The body adapted to the demands placed on it just as it would if you put people on the same diet without the medicine. Same results.