re: Gary Taubes: ‘Obesity isn’t a calorie problem, it’s a hormone problem’

CICO is only a theory. There are several studies that go against it.

I've posted some of these multiple times on this site, its why I get tired of it. Tired of "1st law of thermodynamics".

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We use data in the literature to show that thermogenesis is sufficient to predict metabolic advantage. Whereas homeostasis ensures balance under many conditions, as a general principle, "a calorie is a calorie" violates the second law of thermodynamics.

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CONCLUSION:
None of these equations accurately estimated measured REE in this group of mechanically ventilated patients, most underestimating energy needs. Development of improved predictive equations for adequate assessment of energy needs is needed.

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First Experiment

The excess caloric intakes during the overeating period were 37,300 kcal for subject no. 1 and 20,100 kcal for subject 2.

If these calories had been deposited as fat unassociated with water the weight gain would have amounted to
4.1 and 2.2 kg, respectively. On the assumption that adipose tissue contains 66% fat, these become, respectively, 6.2 kg and 3.3 kg.

The overall weight gains were 1 kg and 1.2 kg, values which fall within the daily fluctuations of body weight.


Second Experiment

All subjects consumed a greater number of excess calories per day than on the first experiment; the mean total excess was 35,000 kcal/person over the whole experiment.

The weekly weight gains appear to bear no relation to the excess calories consumed. It is quite remarkable how some subjects can overeat 8-10,000 excess kilocalories in a week and yet occasionally lose weight.
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The low-protein group consumed, on average, 35,230 excess calories and yet only put on 0.9 kg .. the theoretical weight gain would have amounted to 5.9 kg/person.
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Subject 30 .. increased her weight by only 0.5 kg during 4 following weeks on the low-protein diet despite a further 33,000 excess kilocalories.



Third Experiment

the mean weight gain of the low-protein group was 1.0 kg against an expected 4.7 kg, and that of the high-protein group was 3.8 kg against an expected 4.9kg.

Again it is notable that some subjects are able to eat an excess of 8-10,000 kcal in a week and yet lose weight.

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If CICO was the answer, we'd not get these results. That is why CICO is still only a theory, and a rather bad one at that. Everyone who states "CICO" overlooks the MANY metabolic pathways that exist.



That is all - I'm out of this thread.

First link.....patients in a hospital on vents.
Second link......16 Subject study.

You know what has been proven, over and over and over again? A calorie deficit results in weight loss.