re: Pick 1 Crypto for 2022 with 100k to play with.

If I had $100k to invest in one crypto for 2022, I'd choose Solana. It's been getting a lot of buzz for its fast transaction speeds and low costs, which are significant advantages over Ethereum, especially with the current hype around staking. Solana's ecosystem is rapidly growing, with more developers and projects jumping on board, which could lead to substantial growth this year.
That said, do your own research and diversify to lower risks. As for learning more about optimizing Solana investments, you should check out solana bundler, which provides scripts and helpful information on the cryptocurrency.