re: Favorite Chess openings?

I think it's pretty much been proven as fact at this point, both by human play and computers, that the Sicilian definitely black's best response to e4

I have always absolutely hated to play against it as white.

In fact I now play something called the Smith-Morra gambit against it as white, which is a slightly dubious gambit but has the big advantage of black usually not being familiar with it and at lower levels that's compensation enough.

I mostly play bullet games these days and playing irregular openings is actually a very common strategy in bullet games at all levels.