re: Coronavirus Disease 2019 (COVID-19) ***W.H.O. DECLARES A GLOBAL PANDEMIC***

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Really? That’s pretty interesting.

I was actually just spit balling the other day about whether this is what it looked like when the other 4 coronaviridae crossed over.

Thanks for that info

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The 1889–1890 pandemic probably originated in Central Asia (3) and was characterized by malaise, fever, and pronounced central nervous system symptoms (53). A significant increase in case fatality with increasing age was observed. Absolute evidence that an influenza virus was the causative agent of this epidemic was never obtained, due to the lack of tissue samples from that period. However, postepidemic analysis in 1957 of the influenza antibody pattern in sera of people who were 50 to 100 years old indicated that H2N2 influenza antibodies might have originated from the 1889–1890 pandemic (45). However, it is tempting to speculate about an alternative hypothesis, that the 1889–1890 pandemic may have been the result of interspecies transmission of bovine coronaviruses to humans, resulting in the subsequent emergence of HCoV-OC43. The dating of the most recent common ancestor of BCoV and HCoV-OC43 to around 1890 is one argument. Another argument is the fact that central nervous system symptoms were more pronounced during the 1889–1890 epidemic than in other influenza outbreaks. It has been shown that HCoV-OC43 has neurotropism and can be neuroinvasive

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