Tips for avoiding cramping (hamstring and inner groin) after squats?

I can do one set of rpe 8 on squats and then I have to be done for the day. Serious cramps will occur. I do a 15 minute full body mobility warm up (with emphasis on hip mobility) every morning before working out. I also wear powerlifting shoes for squating.

My stance is fairly wide with toes pointing slightly out. If I go narrow, I lose ankle and hip mobility to even quarter squat. If I push it with a narrow stance, I’ll hurt my back.

I also run 6-8 miles per week on 2-3 mile runs 3 days a week if it matters.
I’ve struggled with this for years.

Any suggestions?