Leaving House Windows Open in Southern Louisiana

Just got back from a trip where we could leave the windows to our rental open all day and not have to worry about running the a/c. Would like to do something similar for a few hours now or for longer once the weather gets cooler. Any issues I should be aware of, like mold / strain on a/c once turned back on, etc. Anything to consider before opening the windows, such as making sure the outside humidity levels are below a certain threshold? Thanks