re: Patients taking Eli Lilly's retatrutide lost 58 pounds, on average, in a phase 2 clinical

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This tells me you have never been significantly anaerobically fit in your life.

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Define significantly. It is easy and simple to gain the ability to do long term steady state cardio, and it doesn’t take long to become decently aerobically fit.

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But that 20kg plate is chasing you around the gym?

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You said “really strong”. Don’t change it to being able to lift what any able-bodied person can lift on day 1 in the gym.

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Try descending a mountain pass at over 50mph with nothing between you and hundreds of feet bouncing off boulders but a guard rail not designed to stop you.

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That’s a sport, it’s not at all necessarily a part of getting fit. Nobody has to go mountain biking to get fit.
Everyone who wants to get “really strong” will step out of the rack with hundreds of pounds on their back.

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I tell you what Mr. Worrell I have a climbing based training day planned for Sunday, 60 miles and just over 17,000 vertical feet of climbing I will put good money up that you can't finish it in 3X the time it takes me to finish if you can even finish the first climb. The next time you have been in the gym for 6 straight hours exercising at a HR of 140-200 never stopping and looking at another set that is going to redline you once again all without A/C then you might have an idea what suffering feels like.

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You’re choosing unnecessary suffering because you like riding a bike in an extreme fashion. Good for you, but you’re not making apt comparisons.