re: Where in the enumerated powers are federal drug laws?

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Interstate commerce

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Been used to justify a lot of Federal overreach…

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Interstate commerce

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I don’t know why you are getting downvoted; that is literally the correct answer to the question that was asked.

And it’s true that the Commerce Clause has been abused, but it’s not apparent that this is a good example of that abuse. I’m not saying it’s valid, just that reasonable people could disagree on this manifestation.