Los Angeles Conference Beginning of March

Where would you go and do if you had 2 days to do whatever?

I've been to San Diego already. First trip to LA.

If no young kids, I would definitely stay away from LEGOLAND. Not much in Downtown LA to do unless you want to see a play or something. There are good restaurants though. Although a Lakers fan, going to a game is a bit boring. A USC or UCLA basketball game is probably more exciting.
SM Pier is ok but can get pretty crowded but you are walking distance to some of the best restaurants in LA. Plus the SM Promenade has some high end shopping.
If you go to Javier's then you are across the street from Crystal Cove. There's a restaurant/bar on the beach there that is really good.
San Diego Zoo is the best.
There's not much in Hollywood besides run-away teen druggies and homeless.
There are a bunch of breweries in the South Bay.
Manhattan Beach or Hermosa are great beach towns to walk around with good restaurants and bars.

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Conference is in this area so I can go out here night of conference.

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There’s a lot of happy hour happenings because of all the big offices and professionals that work down there. At night the bar scene is decent. It’s not pretentious like Hollywood. There are some mostly lower budget nightclubs too (if that’s your thing).

Sounds solid. I haven’t been to little Tokyo in forever, so can’t comment much on it. I remember olvera Street down in that area being pretty cool to spend an afternoon (although I haven’t been down there in forever either).

My biggest recommendation is to skip Hollywood, as it’s a complete shite show. And I think Disney and universal on the same trip is somewhat redundant, with Disney being better. As such, your itinerary looks good.