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re: COVID vaccine evading variant is here.

Posted on 10/26/21 at 9:41 pm to
Posted by idsrdum
Member since Jan 2017
449 posts
Posted on 10/26/21 at 9:41 pm to
quote:

 important to ensure an epitope-biased response across a population


So you think the plan to vaccinate everyone with the mRNA vaccines was a good one?
Posted by crazy4lsu
Member since May 2005
36311 posts
Posted on 10/26/21 at 9:45 pm to
quote:

So you think the plan to vaccinate everyone with the mRNA vaccines was a good one?



A cogent vaccination strategy would have been to use one vaccine to start the process and then introduce others, given the timescale involved. With so many versions already out, and a worldwide distribution of antigens, you can't ensure a narrow antibody spectrum which ensures that everyone is developing antibodies to the same parts of the virus, which makes epitope variance more likely. I don't think anyone envisioned the timescale of this pandemic though.
Posted by ItNeverRains
37069
Member since Oct 2007
25449 posts
Posted on 10/26/21 at 9:51 pm to
shite. Guess I’ll have to keep exercising, a healthy diet, and supporting my immune system.
Posted by Powerman
Member since Jan 2004
162220 posts
Posted on 10/26/21 at 9:53 pm to
quote:

You're the last person who needs to be talking virology, considering how much nonsense I've seen you spew.

He's just a low IQ moron that likes to speak as if he is an authority on everything.
Posted by GumboPot
Member since Mar 2009
118773 posts
Posted on 10/26/21 at 9:55 pm to
quote:

You're the last person who needs to be talking virology, considering how much nonsense I've seen you spew.


So you’re saying viruses with a higher death rate per infection have higher R values? In a general sense how is that possible?
Posted by crazy4lsu
Member since May 2005
36311 posts
Posted on 10/26/21 at 10:10 pm to
quote:

So you’re saying viruses with a higher death rate per infection have higher R values? In a general sense how is that possible?



I'm saying that the Basic Reproduction Number isn't a reflection of a 'higher death rate per infection' because not all routes of infection are the same. The seasonal strains of influenza, spread by droplet transmission, have a lower R value than smallpox, which is spread by the same route. No one would describe influenza as 'more deadly' than smallpox? Measles has an extremely high R number, and has been an extremely virulent virus throughout history. Saying a low R number means a more deadly pathogen is just nonsensical.
Posted by Bulldogblitz
In my house
Member since Dec 2018
26781 posts
Posted on 10/26/21 at 10:12 pm to
If you don't get the jab, you're fired.
Posted by CitizenK
BR
Member since Aug 2019
9436 posts
Posted on 10/26/21 at 10:15 pm to
Had it a month ago, was like a two day mild cold
Posted by GumboPot
Member since Mar 2009
118773 posts
Posted on 10/26/21 at 10:23 pm to
quote:

Saying a low R number means a more deadly pathogen is just nonsensical.


I know the R number is a lagging indicator. However viruses that lead to high death rates per infection will have a low R number simply because they kill their hosts before they spread.
Posted by crazy4lsu
Member since May 2005
36311 posts
Posted on 10/26/21 at 10:31 pm to
quote:

I know the R number is a lagging indicator. However viruses that lead to high death rates per infection will have a low R number simply because they kill their hosts before they spread.



Again, this isn't true. You seem to have a hard time understanding that in infectious disease, transmission routes are meaningfully different. The R number gives the impression that the distribution is even across a population at all times, but in practice it never is, because not all transmission routes are the same. The R number isn't a description of virulence.
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