re: Anyone know someone who suffers from PE?

Not an option for most.

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Will any ssri work?

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Think so. Paxil does. Made me a real "cross country" fricker.

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If this is about premature ejaculation, ask your doc about zoloft 12.5-25mg daily.

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Or for something more on a as needed basis - Dapoxetine. The wikipedia article on Dapoxetine is unclear on what is available in US as far as generic and brand name. There was a sleep medication that had long been generic in larger doses for something else but got approved at a very small dosage for sleep issues, and it then became only available in that brand name at that small dosage & very expensive. It wouldn’t surprise me if this is or at least was a similar situation especially since it appears to be too fast acting to be widely prescribed as a generic anti-depressant treatment.

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Randomized, double-blind, placebo-controlled trials have confirmed the efficacy of dapoxetine for the treatment of PE. Different dosages have different impacts on different types of PE. Dapoxetine 60 mg significantly improves the mean intravaginal ejaculation latency time (IELT) compared to that of dapoxetine 30 mg in men with lifelong PE, but no difference is seen in men with acquired PE. Dapoxetine, given 1–3 hours before sexual episode, prolongs IELT and increases the sense of control and sexual satisfaction in men of 18 to 64 years of age with PE. Since PE is associated with personal distress and interrelationship difficulty, dapoxetine provides help for men with PE to overcome this condition.

With no drug approved specifically for treatment for PE in the US and some other countries, other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used off-label to treat PE. Waldinger's meta-analysis shows that the use of these conventional antidepressants increases IELT two- to nine-fold above baseline, compared to three- to eight-fold when dapoxetine is used. However, these SSRIs may need to be taken daily to achieve meaningful efficacy, and their comparatively longer half-lives increase the risk of drug accumulation and a corresponding increase of adverse effects such as reduced libido.

Dapoxetine, though, is generally categorized as a fast-acting SSRI. It is more rapidly absorbed and mostly eliminated from the body within a few hours. These pharmacokinetics are more favorable in that they might minimize drug accumulation in the body, habituation, and side effects.

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