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re: Data shows cases are up in least vaccinated areas

Posted on 7/31/21 at 11:04 am to
Posted by crazy4lsu
Member since May 2005
36425 posts
Posted on 7/31/21 at 11:04 am to
quote:

Then your position seems to be that, since the virus continually mutates, then there is no way to realistically fight it. So, why have vaccines?



Well the mRNA vaccines are trying to manipulate the virus by putting selective pressure onto the most pathogenic portion of the virus, the spike protein, as these viruses exist as quasispecies in every individual, but still around a predominant strain. If enough people have enough antibodies to what causes the most severe disease, then the virus's genomic options generation to generation are limited significantly, at which point it can reach what is called the error threshold rate, where the mutation rate of the virus exceeds its ability to retain a stable genomic population generation to generation.

The problem with natural immunity is that it relies on memory B cell response, which itself takes time to restart, with chances for reinfection, but also the severity will decrease with subsequent infections. There is also a chance that the initial immune response can create what is called antigenic sin, in which the initial immune response can affect the responses by the immune system to other, closely related antigens, rather than an antigen specific response.

Public health officials have done a poor job describing the theory behind this particular vaccination attempt, and what would optimize it, as without population equilibrium, the effectiveness of piecemeal vaccination approach is limited. It is especially difficult in light of the fact that the infection is worldwide, and to effectively combat it, you need a worldwide approach, not one based on the individual profits of certain companies.

To be clear, the course of a natural infection can possibly make this virus like other common infections, but that will take a long time. The best chance in the interim is to push the virus towards its error threshold rate, which vaccination and natural immunity can do, but unvaccinated populations cannot. The latter serves as a site for prolonged and occult infections as well, which increases the likelihood of robustness of other morphological elements.
This post was edited on 7/31/21 at 12:38 pm
Posted by jimmy the leg
Member since Aug 2007
34784 posts
Posted on 7/31/21 at 12:23 pm to
quote:

The best chance in the interim is to push the virus towards its error threshold rate, which vaccination and natural immunity can do, but unvaccinated populations cannot.


That is totally logical. Thank you for your response. It was enlightening.

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