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re: Ivermectin is the corona killer- Joe Rogan and Doctors discuss
Posted on 7/19/21 at 9:54 am to the808bass
Posted on 7/19/21 at 9:54 am to the808bass
I looked up this.
Struggling to see how that is going to help against a COVID virus in any way.
quote:
Ivermectin binds selectively and with high affinity to glutamate-gated chloride ion channels in invertebrate muscle and nerve cells of the microfilaria. This binding causes an increase in the permeability of the cell membrane to chloride ions and results in hyperpolarization of the cell, leading to paralysis and death of the parasite. Ivermectin also is believed to act as an agonist of the neurotransmitter gamma-aminobutyric acid (GABA), thereby disrupting GABA-mediated central nervous system (CNS) neurosynaptic transmission. Ivermectin may also impair normal intrauterine development of O. volvulus microfilariae and may inhibit their release from the uteri of gravid female worms.
Struggling to see how that is going to help against a COVID virus in any way.
1
Posted on 7/19/21 at 10:05 am to j1897
Helps if you read more than one link, also maybe one that addresses use with covid. Not simply the drug Ivermectin itself. From the first link that popped up when I searched:
quote:
Proposed Mechanism of Action and Rationale for Use in Patients With COVID-19 Reports from in vitro studies suggest that ivermectin acts by inhibiting the host importin alpha/beta-1 nuclear transport proteins, which are part of a key intracellular transport process that viruses hijack to enhance infection by suppressing the host’s antiviral response.4,5 In addition, ivermectin docking may interfere with the attachment of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein to the human cell membrane.6 Ivermectin is thought to be a host-directed agent, which may be the basis for its broad-spectrum activity in vitro against the viruses that cause dengue, Zika, HIV, and yellow fever.4,7-9 Despite this in vitro activity, no clinical trials have reported a clinical benefit for ivermectin in patients with these viruses. Some studies of ivermectin have also reported potential anti-inflammatory properties, which have been postulated to be beneficial in people with COVID-19.10-12
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