re: Anybody here have any Trans loved ones?

One of my best friends is trans. An amazing person, with a wonderful sense of humor.

After taking Endocrinology, Embryology and Ob/Gyn in medical school, respectively, I do find it interesting that the rates of Disorder of Sex Developments seems to correlate strongly with the actual amount of trans people in the US. In fact, there are probably a lot more people who have a Disorder of Sex Development than there are trans people, because the expression of these disorders is on a spectrum, with varying degrees of progression. Suggesting all these people have gender dysphoria without acknowledging the possibility (and even likelihood) of an underlying endocrine disorder seems to misunderstand the issues, as endocrine disorders will have physiological, psychological and social components that we are only beginning to understand. We give a lot of leeway to people who have Disorders of Androgen Synthesis, such as people who have 46 XY with Androgen Insensitivity, and may present initially as female and then transition to male at puberty, or choose to keep themselves female. I don't understand the insistence of writing off every trans person as having gender dysphoria, as even that would have a pathophysiology, which people seem to ignore.