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re: Reports coming in: A lab in San Diego has developed a covid-19 vaccine
Posted on 2/13/20 at 4:15 am to HailHailtoMichigan!
Posted on 2/13/20 at 4:15 am to HailHailtoMichigan!
1) this is not a proven effective vaccine.
2) it’s an algorithm based guess at what would work. We’ve seen the effectiveness of these algorithms with the flu and it is extremely hit or miss.
3) they haven’t made this yet, but are claiming to have it.
It’s pathetic what some companies will do to try and get publicity during a tragedy.
I hope it works, but I am extremely cautious about buying into this.
2) it’s an algorithm based guess at what would work. We’ve seen the effectiveness of these algorithms with the flu and it is extremely hit or miss.
3) they haven’t made this yet, but are claiming to have it.
It’s pathetic what some companies will do to try and get publicity during a tragedy.
I hope it works, but I am extremely cautious about buying into this.
Posted on 2/13/20 at 5:36 am to Geauxgurt
Inovio is definitely playing fast and loose with terminology. They don't have a vaccine for any of those viruses, they have POTENTIAL vaccines. None are tested, proven safe and effective, or approved by any regulatory agency.
Phase I (first-in-human) trials comes next. Small numbers, less than 100 subjects total usually. Only thing you learn from that is if vaccine probably will or will not kill you directly, and if ever-increasing doses create the immune response they *think* may be effective.
That needs to be followed by larger more convincing studies, looking at appropriate dosing regimen (one shot or a series for example) and some hints at efficacy and longer term safety before any regulatory agency will look at it.
Then it takes time to prove that a vaccine works ... remember, it's not something you can measure immediately. You have to immunize subjects at risk (some with the real product, some with placebo), let them go about their normal lives, and over time see if less people receiving the real vaccine develop the disease than those getting placebo.
This all takes time, even with a motivated and well-funded government/pharma company/population.
Inovio developed a covid-19 vaccine candidate in 3 hours, now time to prove if it works.
Phase I (first-in-human) trials comes next. Small numbers, less than 100 subjects total usually. Only thing you learn from that is if vaccine probably will or will not kill you directly, and if ever-increasing doses create the immune response they *think* may be effective.
That needs to be followed by larger more convincing studies, looking at appropriate dosing regimen (one shot or a series for example) and some hints at efficacy and longer term safety before any regulatory agency will look at it.
Then it takes time to prove that a vaccine works ... remember, it's not something you can measure immediately. You have to immunize subjects at risk (some with the real product, some with placebo), let them go about their normal lives, and over time see if less people receiving the real vaccine develop the disease than those getting placebo.
This all takes time, even with a motivated and well-funded government/pharma company/population.
Inovio developed a covid-19 vaccine candidate in 3 hours, now time to prove if it works.
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