re: 66 hours of 72 hour fast

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"To some degree, autophagy is always happening in the body. But as we’ve seen, most people would benefit from more autophagy, most of the time. There are several ways to induce more autophagy, including fasting, ketogenic dieting, exercise, and drugs."

"However, the specifics, like how long you have to fast for or how much exercise you need, should be viewed as tentative and taken with a grain of salt."

"After 48 hours of fasting, some markers of autophagy increase even further, but others have started to reduce to normal levels by that time. Thus, fasts of at least 24 hours may be necessary to induce a state of heightened autophagy in all body tissues, while fasting much more than 48 hours is probably not helpful and may become counterproductive at some point."

"A few practical guidelines:

-Fast for 12–16 hours at least once a week, and maybe as often as every day.
-Fast for around 36 hours at least a few times a year, and no more than once a week.
-Exercise several times a week for at least an hour, and no more than two hours.
-Exercise each individual muscle group at least twice a week for at least 20 minutes, and no more than an hour.
-Exercise each muscle group to the point of exhaustion at least once a week. In other words, deplete that muscle’s glycogen stores.
-Eat at a caloric deficit for most of the year, except when specifically trying to build muscle.
-Spend a few months out of the year in a state of ketosis by following a ketogenic diet.
-Maybe take resveratrol for part of the year, cycling on and off it every so often. The full effects and optimal dosing protocol are unknown, however.

You don’t need to do all of the above, but you should be doing at least two of them—ideally, at least one of the diet habits and one of the exercise habits."