I've been doing what you do for about 8-10 years. I'd start with a moderately-priced piece of luggage and a backback or shoulder bag that can slide over your handle.

At $75-125 you should be satisfied for the time being until you can figure out exactly the setup that works best for you based on your clothing needs, work items/supplies, etc.

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2. Getting in, out and around Airports

All depends on your line of work. I rent a car wherever I go because my trips require me to bounce around client locations that are often not in the urban core of a major city. A buddy of mine just uses lyft/uber since he's going to one site for a day and back to his hotel.

As already mentioned, getting PreCheck is important...will make your life smoother.

Lounge access could be a nice plus depending on the airlines/airports you'll be frequenting. Look for a credit card that comes with Priority Pass or get an AMEX Platinum.

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3. Hotel chains to use

Marriott is now the behemoth so they'll have your most options. But once again, it all depends on your primary sites/locations. For someone that's only going to major cities and staying in urban centers, I'd consider Hyatt as an option.

The big thing through it all it to do your best to pick one airline, hotel, & car rental company. You'll want status as soon as possible given the amount of travel you're doing. Delays, issues, etc. will happen and travel entities take care of their elite customers far better than their "kettles". For me and my territory, Delta with SW as a backup, Marriott, and National are my "go tos". For my colleague, it makes sense for him to focus on American, Hilton, and Hertz.

Once you setup rewards accounts, call their customer service line and note that you're a new, frequent business traveler and are considering using their brand. Ask about a "status challenge" to obtain elite status faster.

Good luck. You'll enjoy it sometimes and hate it others.